Abstract: Geographical mapping and linking of security and risk indicator data. Cross-references are created between location indicators and geo-spatial areas based on a statistical algorithm, in accordance with geo-spatial data. The cross-references are stored in a first data table. A credit risk indicator (CRI) is generated for each geo-spatial area based on other data, forming CRI data that is stored in second data table. A security associated with one of the location indicators is identified among security data. A first link is created between the security and a geo-spatial area based on the cross-references in the first data table. Based on the first link, a second link is created between an indicator among the CRI data in the second data table and the security. The second link is used to form instrument-level data for the security that includes the indicator. The instrument-level data is stored in a third data table.

Abstract: A venous access device includes a hub and a bifurcated cannula. The hub includes a bifurcated connecting arm, a blood sampling arm connected to the bifurcated connecting arm, a fluid transfer arm connected to the bifurcated connecting arm, a blood sampling channel and a fluid transfer channel. The blood sampling channel passes through the blood sampling arm and the bifurcated connecting arm. The fluid transfer channel passes through the fluid transfer arm and the bifurcated connecting arm. The bifurcated cannula is coupled to the bifurcated connecting arm and includes a blood sampling lumen having a blood sampling port, a fluid transfer lumen having a fluid transfer port, and a dividing member separating the blood sampling lumen from the fluid transfer lumen. The blood sampling port is 2 mm to 20 mm proximal from the fluid transfer port. The blood sampling channel is fluidly connected to the blood sampling lumen, and the fluid transfer channel is fluidly connected to the fluid transfer lumen.

Abstract: A venous access device includes a hub and a bifurcated cannula. The hub includes a bifurcated connecting arm, a blood sampling arm connected to the bifurcated connecting arm, a fluid transfer arm connected to the bifurcated connecting arm, a blood sampling channel and a fluid transfer channel. The blood sampling channel passes through the blood sampling arm and the bifurcated connecting arm. The fluid transfer channel passes through the fluid transfer arm and the bifurcated connecting arm. The bifurcated cannula is coupled to the bifurcated connecting arm and includes a blood sampling lumen having a blood sampling port, a fluid transfer lumen having a fluid transfer port, and a dividing member separating the blood sampling lumen from the fluid transfer lumen. The blood sampling port is 2 mm to 20 mm proximal from the fluid transfer port. The blood sampling channel is fluidly connected to the blood sampling lumen, and the fluid transfer channel is fluidly connected to the fluid transfer lumen.

Abstract: An implant may include a curved implant body and a flange extending from the implant body, the flange being thinner than the implant body, the implant body and the flange having a first exterior surface and a second exterior surface opposite the first surface in which the implant body and the flange formed by at least partially fused particles. The particles at the first surface define a first average pore size and the particles at the second surface define a second average pore size; with the first average pore size being greater than the second average pore size. The first surface may be a tissue ingrowth surface and the second surface may be a tissue ingrowth barrier.

Abstract: A method of selecting a breakaway connector apparatus for attachment to a needle-free connector on an intravenous (IV) line is provided. The method includes providing a needle-free connector for attachment to a breakaway connector. The needle-free connector includes a push-out force associated with the needle-free connector. The method further includes identifying the push-out force imparted by the needle-free connector, and identifying a desired range of separation force associated with separating a first portion of the IV line from a second portion of the IV line. The method further includes selecting a breakaway connector device including a housing and a breakaway component that is configured to detach from the housing when a breakaway force is applied to the device, such that a sum of the breakaway force and the push-out force is within the desired range of separation force.

Abstract: An orthopaedic surgical instrument system includes a first broach including a first end configured to be separately secured to a handle and a tapered body having a plurality of cutting teeth defined therein, and a second broach including a first end configured to be separately secured to the handle in place of the first broach, a first tapered body extending distally from a second end positioned opposite the first end, and a second tapered body extending distally from the first tapered body. The tapered body of the first broach and the first tapered body of the second broach have a first outer geometry and the second tapered body has a second outer geometry different from the first outer geometry.

Abstract: An apparatus for reducing emissions that has a combustion turbine that feeds exhaust into a heat recovery steam generator (or HRSG) casing in which is positioned an emission reduction system featuring, in gas flow sequence, a first reducing reductant injector (RRI1), as in an ammonia injection grid, for providing reducing reductant, preferably ammonia, into turbine exhaust travelling within the HRSG, followed by a first SCR reactor positioned downstream of the first RRI1, followed by one of either (i) a turbulence generator (TG) as in a static mixer, or (ii) a second RRI2 as in a second ammonia injection grid, or (iii) an RRI2 with integrated TG supported on injectors of RRI2, then followed by a second SCR reactor. The emission reduction system preferably is free of a separate body oxidation catalyst or a separate body ammonia slip catalyst in an effort to utilize a limited volume within the HRSG. Methods of assembling and operating the ERS or T-H combination with ERS are also featured.

Abstract: An apparatus for reducing emissions that has a combustion turbine that feeds exhaust into a heat recovery steam generator (or HRSG) casing in which is positioned an emission reduction system featuring, in gas flow sequence, a first reducing reductant injector (RRI1), as in an ammonia injection grid, for providing reducing reductant, preferably ammonia, into turbine exhaust travelling within the HRSG, followed by a first SCR reactor positioned downstream of the first RRI1, followed by one of either (i) a turbulence generator (TG) as in a static mixer, or (ii) a second RRI2 as in a second ammonia injection grid, or (iii) an RRI2 with integrated TG supported on injectors of RRI2, then followed by a second SCR reactor. The emission reduction system preferably is free of a separate body oxidation catalyst or a separate body ammonia slip catalyst in an effort to utilize a limited volume within the HRSG. Methods of assembling and operating the ERS or T-H combination with ERS are also featured.

Abstract: A breakaway connector apparatus including a housing and a breakaway component is configured for attachment directly to a needle-free fitting on an intravenous line. The breakaway connector apparatus includes only one valve. The apparatus is configured to open both the valve and a seal on the needle-free fitting when the breakaway component is attached to the needle-free fitting. When tension is applied to the connector, the breakaway component is configured to detach from the apparatus while remaining attached to the needle-free fitting, thereby closing the valve on the apparatus and also closing the seal on the needle-free fitting. In some embodiments, the breakaway connector apparatus includes one or more securing arms and one or more corresponding securing bars to prevent re-connection of the apparatus following disengagement of the breakaway component from the apparatus.

Abstract: An implant that can function as a tissue suspension implant. Embodiments find particular use in connection with eyebrow or forehead lifts, which require raising of soft tissue and skin of the forehead and brow.

Abstract: A breakaway medical tubing connector includes a first side member comprising a first housing having an inner wall, a first channel disposed within the first housing, and a first valve disposed within the first channel, wherein the first valve is an active valve and wherein the first valve comprises a diaphragm forming a first seal with the inner wall. The apparatus includes a second side member comprising a second housing, a second channel disposed within the second housing, a second valve disposed within the second channel, and a cannula extending from the second side member toward the first side member. The apparatus further includes a toric joint between the cannula and the first side member, wherein the toric joint forms a second seal between the first and second side members.

Abstract: A venous access device includes a hub and a bifurcated cannula. The hub includes a bifurcated connecting arm, a blood sampling arm connected to the bifurcated connecting arm, a fluid transfer arm connected to the bifurcated connecting arm, a blood sampling channel and a fluid transfer channel. The blood sampling channel passes through the blood sampling arm and the bifurcated connecting arm. The fluid transfer channel passes through the fluid transfer arm and the bifurcated connecting arm. The bifurcated cannula is coupled to the bifurcated connecting arm and includes a blood sampling lumen having a blood sampling port, a fluid transfer lumen having a fluid transfer port, and a dividing member separating the blood sampling lumen from the fluid transfer lumen. The blood sampling port is 2 mm to 20 mm proximal from the fluid transfer port. The blood sampling channel is fluidly connected to the blood sampling lumen, and the fluid transfer channel is fluidly connected to the fluid transfer lumen.

Abstract: A breakaway medical tubing connector and method for joining two sections of medical tubing includes a pump side member and a patient side member positioned axially opposite from the pump side member. The patient side member has a first channel disposed within the pump side member and a first valve disposed within the first channel. The pump side member has a second channel disposed within the patient side member and a second valve disposed within the second channel. The first valve may be an active valve and the second valve may be a passive valve. A securing bar may be disposed on the pump side member and a securing arm may be disposed on the patient side member for providing a detachable coupling of the two members.

Abstract: The invention provides certain difluorocyclohexyl-imidazopyridazinyl-imidazolidinone compounds of formula II as IL-17A inhibitors, pharmaceutical compositions thereof, and methods of using a compound of formula II to treat certain symptoms of psoriasis, rheumatoid arthritis or multiple sclerosis.

Abstract: A breakaway medical tubing connector and method for joining two sections of medical tubing includes a pump side member and a patient side member positioned axially opposite from the pump side member. The patient side member has a first channel disposed within the pump side member and a first valve disposed within the first channel. The pump side member has a second channel disposed within the patient side member and a second valve disposed within the second channel. The first valve may be an active valve and the second valve may be a passive valve. A securing bar may be disposed on the pump side member and a securing arm may be disposed on the patient side member for providing a detachable coupling of the two members.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: A breakaway medical tubing connector and method for joining two sections of medical tubing includes a pump side member and a patient side member positioned axially opposite from the pump side member. The patient side member has a first channel disposed within the pump side member and a first valve disposed within the first channel. The pump side member has a second channel disposed within the patient side member and a second valve disposed within the second channel. The first valve may be an active valve and the second valve may be a passive valve. A securing bar may be disposed on the pump side member and a securing arm may be disposed on the patient side member for providing a detachable coupling of the two members.

Abstract: The invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: An orthopaedic surgical instrument system includes a first broach including a first end configured to be separately secured to a handle and a tapered body having a plurality of cutting teeth defined therein, and a second broach including a first end configured to be separately secured to the handle in place of the first broach, a first tapered body extending distally from a second end positioned opposite the first end, and a second tapered body extending distally from the first tapered body. The tapered body of the first broach and the first tapered body of the second broach have a first outer geometry and the second tapered body has a second outer geometry different from the first outer geometry.

Abstract: A venous access device includes a hub and a bifurcated cannula. The hub includes a bifurcated connecting arm, a blood sampling arm connected to the bifurcated connecting arm, a fluid transfer arm connected to the bifurcated connecting arm, a blood sampling channel and a fluid transfer channel. The blood sampling channel passes through the blood sampling arm and the bifurcated connecting arm. The fluid transfer channel passes through the fluid transfer arm and the bifurcated connecting arm. The bifurcated cannula is coupled to the bifurcated connecting arm and includes a blood sampling lumen having a blood sampling port, a fluid transfer lumen having a fluid transfer port, and a dividing member separating the blood sampling lumen from the fluid transfer lumen. The blood sampling port is 2 mm to 20 mm proximal from the fluid transfer port. The blood sampling channel is fluidly connected to the blood sampling lumen, and the fluid transfer channel is fluidly connected to the fluid transfer lumen.