Abstract: A patella drill guide includes a base portion rotatably mounted on a bone-gripping component. A trial portion with a contoured articulation surface is above the base portion. The base portion and trial portion have aligned drill guide bores. The base portion and trial portion can be rotated together on the bone-gripping component to optimize the positions of the drill guide bores with respect to the patella surface, thereby optimizing the locations of the mounting pegs of the patella implant component on the patella to optimize the orientation of the patella implant component. The base and the bone-gripping component may be unitary so that the entire assembly rotates on the patella about the central longitudinal axis of the bone-gripping component.

Abstract: A venous access device includes a hub and a bifurcated cannula. The hub includes a bifurcated connecting arm, a blood sampling arm connected to the bifurcated connecting arm, a fluid transfer arm connected to the bifurcated connecting arm, a blood sampling channel and a fluid transfer channel. The blood sampling channel passes through the blood sampling arm and the bifurcated connecting arm. The fluid transfer channel passes through the fluid transfer arm and the bifurcated connecting arm. The bifurcated cannula is coupled to the bifurcated connecting arm and includes a blood sampling lumen having a blood sampling port, a fluid transfer lumen having a fluid transfer port, and a dividing member separating the blood sampling lumen from the fluid transfer lumen. The blood sampling port is 2 mm to 20 mm proximal from the fluid transfer port. The blood sampling channel is fluidly connected to the blood sampling lumen, and the fluid transfer channel is fluidly connected to the fluid transfer lumen.

Abstract: The invention provides a combination comprising compounds of formula (I) or salts thereof, and one or more therapeutic agents.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: A patella drill guide includes a base portion rotatably mounted on a bone-gripping component. A trial portion with a contoured articulation surface is above the base portion. The base portion and trial portion have aligned drill guide bores. The base portion and trial portion can be rotated together on the bone-gripping component to optimize the positions of the drill guide bores with respect to the patella surface, thereby optimizing the locations of the mounting pegs of the patella implant component on the patella to optimize the orientation of the patella implant component. The base and the bone-gripping component may be unitary so that the entire assembly rotates on the patella about the central longitudinal axis of the bone-gripping component.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: A patella drill guide includes a base portion rotatably mounted on a bone-gripping component. A trial portion with a contoured articulation surface is above the base portion. The base portion and trial portion have aligned drill guide bores. The base portion and trial portion can be rotated together on the bone-gripping component to optimize the positions of the drill guide bores with respect to the patella surface, thereby optimizing the locations of the mounting pegs of the patella implant component on the patella to optimize the orientation of the patella implant component. The base and the bone-gripping component may be unitary so that the entire assembly rotates on the patella about the central longitudinal axis of the bone-gripping component.

Abstract: A method is provided through which information about media files embedded in web pages is obtained from a server and analyzed to determine if the media files are playable on a device. This information may be external to the media file or may be a portion of the media file itself. The determination of whether a media file is playable by a device is made based on information obtained from the server without downloading the entirety of the media file.

Abstract: A patella drill guide includes a base with a flat patella bone-facing surface, a drill guide bore extending through the base, a cantilever spring member and a bone-gripping member. The cantilever spring member biases the bone-gripping member and the flat patella bone-facing surface toward each other. Flexing the cantilever spring member moves the bone-gripping member away from the flat patella bone-facing surface so that the drill guide can be placed on the patella. When the cantilever spring member is released, the patella is clamped between the bone-gripping member and the flat patella bone-facing surface. The drill guide may have sizing indicia and may be part of a kit including trial components to be mounted to the drill guide.

Abstract: The present invention is directed to a polymorph of a compound and salts of a compound and polymorphs thereof, which compound is an inhibitor of kinase activity.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: Method and apparatus for making biofuels such as biodiesel and bioethanol or animal foodstuff by treating lignocellulosic material by subjecting the material to microwave radiation at the resonant frequency of the lignin to dissociate the lignin.

Abstract: The present invention is directed to novel polymorphs and salts of a compound which is an inhibitor of kinase activity.

Abstract: A modular knee prosthesis system includes a femoral component having a stem, a plurality of different sizes of sleeves mountable on the stem, and a plurality of different sizes of augments mountable on the femoral component. The system is modular, and provides the surgeon with the option of distally offsetting the joint line by selecting the size of sleeve that will provide the desired joint line. The different sizes of sleeves have different axial lengths but share a common geometry along a substantial part of their lengths so that the same bone cavity will accept multiple sizes of sleeves.

Abstract: An orthopaedic surgical instrument system includes a first broach including a first end configured to be separately secured to a handle and a tapered body having a plurality of cutting teeth defined therein, and a second broach including a first end configured to be separately secured to the handle in place of the first broach, a first tapered body extending distally from a second end positioned opposite the first end, and a second tapered body extending distally from the first tapered body. The tapered body of the first broach and the first tapered body of the second broach have a first outer geometry and the second tapered body has a second outer geometry different from the first outer geometry.

Abstract: A modular knee prosthesis system includes a femoral component having a stem and a plurality of different sizes of sleeves mountable on the stem. The system is modular, and provides the surgeon with the option of distally offsetting the joint line by selecting the size of sleeve that will provide the desired joint line. The different sizes of sleeves have different axial lengths but share a common geometry along a substantial part of their lengths so that the same bone cavity will accept multiple sizes of sleeves.

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): And salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

Abstract: Embodiments of the present invention are directed to an electronic funds transfer authentication system and method to facilitate the verification and authentication of a user and the ownership of the source account from which funds are being transferred to another account. The user and transfer data is validated, and then the electronic funds transfer is validated using payment analytics that analyze the behavioral characteristics of the user which may be derived from both internal and external sources of information. Using a unique combination of security measures and procedures, the risk associated with various types of fund transfers is reduced, thereby enabling a financial institution to protect its customers' accounts with a greater degree of certainty.

Abstract: The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

Abstract: A method is provided through which information about media files embedded in web pages is obtained from a server and analyzed to determine if the media files are playable on a device. This information may be external to the media file or may be a portion of the media file itself. The determination of whether a media file is playable by a device is made based on information obtained from the server without downloading the entirety of the media file.