Abstract: The present invention relates to novel bicyclic compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. These compounds are useful in the treatment and prevention of various disorders that are related to ?4?2 nicotinic receptors.

Abstract: The present invention relates to a stable liquid formulation comprising desoximetasone, isopropyl myristate, a C2-C4 alcohol and a stabilizing agent. Specifically, the present invention provides a liquid formulation comprising: a) about 0.01 wt % to about 2.5 wt % desoximetasone; b) about 10 wt % to about 70 wt % isopropyl myristate; c) about 20 wt % to about 70 wt % C2-C4 alcohol; and d) a stabilizing agent selected from the group consisting of an oleaginous vehicle and a propellant, wherein the stabilizing agent is in an amount sufficient to reduce the formation of less than about 1 wt % 17-carboxy-9?-fluoro-11?-hydroxy-16?-methyl-androsta-1,4-diene-3-one under an accelerated storage condition.

Abstract: Method and system for providing increased frequency of flash memories compatible to Serial Peripheral Interface (SPI) bus protocol by delayed data capturing so that system boot loader down load time reduces for a given memory configuration. Methods and systems are provided for operating the memory at the device rated frequency.

Abstract: The present invention provides a novel crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical compositions comprising it.

Abstract: The present invention provides a novel process for reducing palladium content in fosaprepitant dimeglumine.

Abstract: A reverse osmosis element is provided. The reverse osmosis element includes a plurality of permeate tubes arranged to form a core frame. The reverse osmosis element further includes a plurality of leaves wound over the core frame. Each leaf of the plurality of leaves is coupled to one permeate tube of the plurality of permeate tubes. A retentate channel is defined by the plurality of permeate tubes of the core frame, and sealed by the plurality of leaves wound over the core frame. The reverse osmosis element includes first and a second end caps coupled to the plurality of permeate tubes. At least one of the first and the second end caps includes a retentate discharge port, and at least one of the first and second end caps includes one or more permeate discharge ports.

Abstract: A technique and corresponding circuitry are presented for a process independent, self-calibrating relaxation based clock source. The technique and circuitry presented here can reduce the time and cost needed for calibration significantly. The relaxation based clock source produces a clock signal whose frequency is dependent upon a trim value. Starting from an initial trim value, the clock signal is generated, its frequency is compared with a reference clock frequency value, and the trim value is correspondingly adjusted up or down a bit at a time. After this process has continued for a while, min-max logic is used to determine the maximum and minimum trim values and, based on these, the final trim value for the clock is set. This calibration process can also be used to extract whether, and by how much, the implementation on silicon of a particular chip lies in the fast or slow process corners.

Abstract: The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.

Abstract: The present application provides a robust system and method for detecting the watermark in an electronic media, wherein the electronic media had gone through various kinds of attacks and their combinations thereof which may not be known while detecting the watermarks. The watermark detection system and method can be trained to detect or reject a particular pattern. The watermark detection system and method are based on correlation and are useful in any kind of digital watermarking applications. The watermark detection system and method perform well even when the amount of distortion is not precisely known, wherein the disclosure provides a set of templates or correlation filters, being designed for detection of watermark to cover any kind and combination of attacks. For synchronous attacks, the correlation filter designing is carried out dynamically. Particularly, the template i.e. correlation filter is an attack adaptive frequency domain pattern for watermark detection.

Abstract: A method and apparatus are provided for mapping addresses between one or more slave devices and at least one corresponding master device in a multilayer interconnect system including a plurality of bus matrices for interfacing between the one or more slave devices and the master device. The method and apparatus are operative for receiving an address map corresponding to the system, receiving information regarding connectivity of one or more slave devices through at least one of the bus matrices, determining whether the master device has more than one default slave unit associated therewith, and, when the master device has more than one default slave unit associated therewith, generating first and second address mappings and configuring the system to have no more than one default slave unit per master device.

Abstract: Embodiments to increase the capacity of the evaporator of a vapor-compression refrigeration system are described. The refrigeration system may be configured to have a first stage suction line heat exchanger and a second stage suction line heat exchanger. The refrigerant exiting the evaporator can be heated by the first heat exchanger. A thermal bulb of an expansion device, such as a thermostatic expansion valve (TXV) can be positioned downstream of the first heat exchanger. The thermal bulb is capable of regulating a variable volume of refrigerant through the expansion device in response to temperature changes. Thus, the superheat refrigerant vapor region in the evaporator can be reduced, thereby increasing the efficiency of the refrigeration system. The refrigerant exiting the evaporator is a liquid/vapor refrigerant mixture. The mixture can be vaporized to a refrigerant vapor in the first heat exchanger.

Abstract: A gas turbomachine includes a casing having a first casing half including first and second edge portions and a second casing half including first and second edge sections. The first edge portion is configured and disposed to be joined to the first edge section to form a first horizontal joint and the second edge portion is configured and disposed to be joined to the second edge section to form a second horizontal joint. At least one of the first edge portion and the first edge section including a first fluid passage, and at least one of the second edge portion and second edge section including a second fluid passage. The first and second fluid passages are configured and disposed to guide heated fluid along respective ones of the first and second horizontal joints.

Abstract: A computer-implemented method, a video service assurance system, and a wireless network with video service assurance provide analytics associated with video services in a network, such as Long Term Evolution (LTE) wireless networks, and actionable recommendations to improve the video services. In particular, the computer-implemented method of video service assurance includes obtaining measurement data and statistics from at least one network element in a network related to a plurality of video streams thereon, performing data aggregation and analysis with the measurement data and statistics related to the video streams, and providing actionable recommendations for improvement of the video streams to the at least one network element based on the data aggregation and analysis.

Abstract: A bus interconnect for interconnecting one or more master devices with one or more slave devices in a system includes at least one slave interface module adapted for communicating with a corresponding one of the master devices and at least one master interface module adapted for communicating with a corresponding one of the slave devices. The bus interconnect further includes a configurable response module coupled with the slave interface module. The configurable response module is operative to generate different configurable responses associated with access requests to corresponding portions of an address space of the system.

Abstract: System(s) and method(s) for embedding and extracting a watermark from a digital media are described. The method may include generating a plurality of random patterns where the plurality of random patterns includes at least a primary random pattern and a secondary random pattern. The random patterns are indicative of patterns to be embedded to the digital media. The method may further include converting at least the primary random pattern and the secondary random pattern to a bipolar form. The primary random pattern and the secondary random pattern thereof are converted to a primary bipolar random pattern and a secondary bipolar random pattern. The method may also include embedding one or more of the primary bipolar random pattern and the secondary bipolar random pattern in the digital media as the watermark based on a watermark ID, where the watermark ID is a random pattern.

Abstract: The present invention relates to (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine, its salt forms, and to processes for the commercial-scale production of these compounds in sufficient purity and quality for use in pharmaceutical compositions.

Abstract: A gas turbomachine includes a turbine portion including at least one turbine wheel, and a wheel shaft operatively connected to the at least one turbine wheel. The wheel shaft includes an outer surface. A stationary member includes an inner surface positioned outward of the outer surface of the wheel shaft to form a purge flow passage. A bearing housing is linked to the stationary member and spaced radially outward of the wheel shaft. The bearing housing includes at least one purge flow passage configured and disposed to guide a purge flow toward the wheel shaft. At least one of the outer surface of the wheel shaft and the inner surface of the stationary member includes a roughness inducing coating configured and disposed to increase drag and residence time of purge flow in the purge flow passage.

Abstract: A method and system for blind audio watermarking has been envisaged. The system embeds an in-audible watermark by modifying a predetermined singular value in the wavelet domain. The generated watermarked audio signals are robust again Gaussian noise and other watermark removal and compression attacks. Also, the system can perform watermark extraction/detection in real-time without requiring in advance, either the original audio signal or its processed parameters. Thereby, the method and system provide a real-time, efficient technique for blind audio watermarking.

Abstract: The present invention relates to a process for obtaining pure aprepitant substantially free of undesired diastereomeric isomer, namely 5-[2(S)-[1(RS)-[3,5-bis(trifluoromethyl)-phenypethoxy]-3-(S)-(4-fluorophenyl)-morpholin-4-yl-methyl]-3,4-dihydro-2H-1,2,4-triazol-3-one. The present invention further provides an improved process for preparation of aprepitant crystalline form II. The present invention also relates to novel amorphous form of aprepitant, a process for its preparation and to a pharmaceutical composition comprising it. The present invention further relates to aprepitant having a mean particle size of less than about 11.5 microns, a process for its preparation and to a pharmaceutical composition comprising it. Thus, for example, aprepitant having a content of diastereomeric impurity of 1.1% is dissolved in ethyl acetate at 70° C., the solution is concentrated to half the initial volume by distilling off ethyl acetate, and the resulting solid is collected at 0-5° C.

Abstract: According to one aspect of the invention, a method of manufacturing an impingement sleeve for a turbine engine combustor includes placing a first metal sheet in a first die, pressing the first metal sheet in the first die to form a first vertical half of the impingement sleeve, placing a second metal sheet in a second die and pressing the second metal sheet in the second die to form a second vertical half of the impingement sleeve. The method also includes forming holes in the first vertical half and second vertical half while the first vertical half and second vertical half remain separate, positioning the first vertical half and second vertical half about a transition piece and welding the first vertical half to the second vertical half to form the impingement sleeve.