Abstract: The present disclosure relates to substituted phenyl sulfonyl phenyl triazole thiones, pharmaceutical compositions containing them, and methods of using them.

Abstract: A system and method for determining a filter clog. A method includes providing light to a fiber optic cable arranged on a filter, transmitting the light from the fiber optic cable, and detecting an intensity of the light. The method may include predicting a filter clog based on the detection of the intensity of the light; and providing an indication of the filter clog.

Abstract: Disclosed is a system for conditioning air, the system comprising: a heat exchanger comprising a plurality of heat transfer tubes extending between an accumulation header and an outlet header, an internal volume, and an external surface, wherein an air mover is disposed in fluid communication with an air mover in fluid communication with an air inlet and an air outlet, wherein the air mover is configured to urge a flow of air to be conditioned across the external surface of the heat exchanger, a reactor comprising an adsorbent material, a reactor inlet in fluid communication with the outlet header, and a reactor outlet, a vacuum pump comprising a vacuum pump inlet in fluid communication with the reactor outlet and a vacuum pump outlet in fluid communication with a system exhaust.

Abstract: A method and system for utilizing integrated fiber optic sensors to provide continuous feedback. A method includes receiving sensor data from a plurality of fiber optic sensors, aggregating first fiber optic cables corresponding to the plurality of fiber optic sensors, and transmitting the sensor data through a second fiber optic cable to a connector.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract: A system includes a plurality of containers and a plurality of controllers. Each of the controllers are associated with a respective one of the plurality of containers. An unmanned aerial vehicle is configured for wireless communication with the plurality of controllers.

Abstract: An embodiment for generating an electronic coupon based on user preferences is provided. The embodiment may include receiving real-time and historical data relating to one or more reward coupons. The embodiment may also include identifying a contextual situation of the user and one or more preferences of the user regarding a coupon reward type. The embodiment may further include identifying one or more vendors that match with the one or more preferences of the user. The embodiment may also include generating one or more electronic coupons and presenting the one or more generated electronic coupons to the user. The embodiment may further include in response to determining the one or more generated electronic coupons match at least one preference of the user, adding the one or more generated electronic coupons that match the at least one preference of the user to an account of the user.

Abstract: In various examples, an integrated circuit includes first and second portions operating within separate domains. The second portion has an interface that connects the first and second portions. The second portion selectively locks the interface to prevent communication with the first portion over the interface, and selectively unlocks the interface to allow communication with the first portion over the interface.

Abstract: An adhesive formulation such as a hot melt adhesive or a pressure sensitive adhesive is provided comprising 5 to 98% (by weight) biodegradable substantially non-crystalline mcl-PHA. The mcl-PHA may be cured with a peroxide curing agent. The adhesive formulation may include an additional biodegradable polymer, or a non-biodegradable thermoplastic elastomer. Hot melt adhesives comprising significant amounts of biodegradable mcl-PHA, waxes, and tackifiers are also provided.

Abstract: A processor may receive data regarding an emergency event. The processor may identify, using an artificial intelligence model, one or more features regarding the emergency event. The processor may determine that the one or more features are associated with one or more emergency response tasks. The processor may generate an action plan that incorporates the one or more emergency response tasks. The processor may output the action plan to a user.

Abstract: There is described a method of growing a plant having at least one light absorbing pigment, the at least one light absorbing pigment absorbing optical energy at absorbing wavelengths. The method generally has illuminating the plant growing light, the growing light having optical energy within at least two spectral regions each encompassing a given wavelength, the given wavelengths being out of tune with the absorbing wavelengths of the at least one light absorbing pigment, the at least two spectral regions being selected from a group consisting of a first spectral region below 400 nm, a second spectral region at about 430 nm, a third spectral region at about 480 nm, a fourth spectral region at about 595 nm, a fifth spectral region at about 640 nm, a sixth spectral region at about 660 nm and a seventh spectral region at about 675 nm.

Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes.

Abstract: The present invention relates to inhibitors of apoptosis signal-regulating kinase 1 (“ASK1”), a process for synthesis of the compounds of the present invention, composition comprising the compounds and use of the compounds for inhibition of ASK1.

Abstract: In some aspects, the techniques described herein relate to a semiconductor device including: a substrate having a first side and a second side, the second side being opposite the first side; active circuitry disposed on the first side of the substrate; a metallic implant disposed in the substrate, the metallic implant being a blanket implant on the second side of the substrate; and a metallic layer disposed on the second side of the substrate, the metallic layer and the second side of the substrate including the metallic implant defining an ohmic contact.

Abstract: In some aspects, the techniques described herein relate to an electronic device including: a substrate; a metallization layer, the metallization layer having: a first surface disposed on the substrate; a second surface opposite the first surface; and a corrosion-prevention implant layer disposed in the metallization layer, the corrosion-prevention implant layer extending from the second surface to a depth from the second surface in the metallization layer, the depth being less than a thickness of the metallization layer; and an electrical connector coupled with the second surface.

Abstract: The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.

Abstract: The present invention relates to combinations of GPR119 receptor agonists with DPP-4 inhibitors and their use thereof for treating or preventing cardiovascular and metabolic disorders, including diabetes mellitus, non-alcoholic fatty liver disease (NAFLD), NAFL, NASH, dyslipidemia, and related disorders thereto.

Abstract: An object of the invention is to provide compounds as selective JAK1 inhibitor, a process for preparation of the inhibitors, a composition containing the compounds and utility of the compounds.

Abstract: The present invention discloses a process for the oxidation of fatty acids comprises reacting fatty acid with O2 containing O3 for a period of 0.1-60 min at a temp in the range of ?78 to 30 deg C. to obtain the corresponding products, wherein the conversion of the fatty acid is in the range of 80% to 100% and the process is catalyst free and co-oxidant free.