Patents by Inventor Srinivasan Vijayaraghavan

Srinivasan Vijayaraghavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230017316
    Abstract: A device may receive project management data associated with development of a software product and may process a first portion of the project management data, with first models, to generate timeliness scores and an overall timeliness score for the software product. The device may process a second portion of the project management data, with second models, to generate quality scores and an overall quality score for the software product and may process a third portion of the project management data, with third models, to generate product readiness scores and an overall product readiness score for the software product. The device may utilize a fourth machine learning model, with the overall timeliness score, the overall quality score, and the overall product readiness score, to generate a success probability for the software product and may perform one or more actions based on the success probability for the software product.
    Type: Application
    Filed: July 19, 2021
    Publication date: January 19, 2023
    Inventors: Aditi KULKARNI, Roopalaxmi MANJUNATH, Sudha SRINIVASAN, Rajesh NAGARAJAN, Koushik M. VIJAYARAGHAVAN, Nishanth KUMAR, Sudhir HANUMANTHAPPA, Parul JAGTAP, Sangeetha JAYARAM
  • Publication number: 20220249598
    Abstract: Compositions targeting sperm calcineurin may be used as topical and reversible contraceptives. The compositions may include calcineurin inhibitors such as tacrolimus (e.g. FK506) and/or Cyclosporin A. The compositions may be gels, creams, or lotion-based formulations and may be used reversibly and locally for both males and females.
    Type: Application
    Filed: June 10, 2020
    Publication date: August 11, 2022
    Applicant: Kent State University
    Inventors: Srinivasan VIJAYARAGHAVAN, Souvik DEY, Alaa EISA
  • Publication number: 20030104495
    Abstract: This invention provides isolated nucleic acid encoding sperm-specific protein kinase A anchoring proteins from mammalian species, recombinant expression constructs encoding said mammalian sperm-specific protein kinase A anchoring proteins, cells transformed with said constructs, and homogenous preparations of these proteins prepared using recombinant genetic techniques. The invention also provides analytic tools such as polyclonal antisera and monoclonal antibodies specific for said sperm-specific protein kinase A anchoring proteins of the invention. The invention also provides methods for isolating nucleic acid encoding mammalian sperm-specific protein kinase A anchoring proteins and recombinant genetic methods for producing said mammalian sperm-specific protein kinase A anchoring proteins of the invention.
    Type: Application
    Filed: September 16, 2002
    Publication date: June 5, 2003
    Inventors: Daniel W. Carr, Srinivasan Vijayaraghavan
  • Patent number: 6451528
    Abstract: This invention provides isolated nucleic acid encoding sperm-specific protein kinase A anchoring proteins from mammalian species, recombinant expression constructs encoding said mammalian sperm-specific protein kinase A anchoring proteins, cells transformed with said constructs, and homogenous preparations of these proteins prepared using recombinant genetic techniques. The invention also provides analytic tools such as polyclonal antisera and monoclonal antibodies specific for said sperm-specific protein kinase A anchoring proteins of the invention. The invention also provides methods for isolating nucleic acid encoding mammalian sperm-specific protein kinase A anchoring proteins and recombinant genetic methods for producing said mammalian sperm-specific protein kinase A anchoring proteins of the invention.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: September 17, 2002
    Assignee: Oregon Health & Sciences University
    Inventors: Daniel W. Carr, Srinivasan Vijayaraghavan
  • Patent number: 6011013
    Abstract: The present invention includes a pharmaceutical composition having an effective contraceptive amount of a synthetic peptide that includes an amphipathic .alpha.-helix domain that binds to an RII subunit of protein kinase A, and competitively inhibits the binding of protein kinase A to sperm A kinase anchoring proteins. Particular disclosed synthetic peptides having this activity include s-Ht31: N-Stearate-DLIEEAASRIVDAVIEQVKAAGAY (SEQ ID No. 9), s-Ht31-P: N-Stearate-DLIEEAASRPVDAVPEQVKAAGAY (SEQ ID No. 10), and s-AKAP79: N-Stearate-YETLLIETASSLVKNAIQLSIE (SEQ ID No. 11). The invention also includes methods of inhibiting sperm motility, by exposing them to an effective amount of the peptide, for example by placing the pharmaceutical composition (such as a suppository, foam, cream, or gel) in the vagina.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: January 4, 2000
    Assignee: Oregon Health Sciences University
    Inventors: Daniel W. Carr, Srinivasan Vijayaraghavan
  • Patent number: 5439884
    Abstract: A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: August 8, 1995
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasa R. Nagalla, Srinivasan Vijayaraghavan, Anthony Archibong
  • Patent number: 5436137
    Abstract: A pure DNA encoding a peptide which is capable of promoting acrosome reaction and the encoded peptide. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, a method of promoting fertilization using such a peptide, and a method of preparing such a peptide by recombinant technology.
    Type: Grant
    Filed: March 23, 1993
    Date of Patent: July 25, 1995
    Assignee: Oregon Regional Primate Research Center
    Inventors: Eliot R. Spindel, Srinivasan Vijayaraghavan, Srinivasa R. Nagalla, Kang Li