Abstract: A tubing and ferrule assembly for use in joining a clad tubing to a fitting. The ferrule is bound to the clad tubing, which includes a partial jacket of stainless steel, such that the inert core protrudes from, and has a common outer diameter with, the jacket. The ferrule is bound to the jacket slightly more distant than necessary for the inert core to contact a fining. When the ferrule is retained in place, the inert core is compressed and provides a true zero dead volume connection between the clad tubing and the fitting. The relationship of the ferrule, the clad tubing, and the fitting limits the position of the clad tubing and therefore precludes damaging of the associated valve or component.

Abstract: A temperature controller for simultaneously controlling the temperatures of a plurality of heating elements for use in chromatographic analysis including columns, detectors, valves, transport lines and other components.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

Abstract: A combined pump-injector valve system utilizing a monolithic body to provide the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample. The pump-injector valve system further includes a pressure sensor external the barrel of the pump and may include an interim position intermediate loading and injection where the contents of the barrel may be pressurized to a desired pressure.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

Abstract: The disclosure pertains to a tubing and ferrule assembly for use in joining a clad tubing to a fitting. The ferrule is bound to the clad tubing, which includes a partial jacket of stainless steel, such that the inert core protrudes from, and has a common outer diameter with, the jacket. The ferrule is bound to the jacket slightly more distant than necessary for the inert core to contact a fitting. When the ferrule is retained in place, the inert core is compressed and provides a true zero dead volume connection between the clad tubing and the fitting. The relationship of the ferrule, the clad tubing, and the fitting limits the position of the clad tubing and therefore precludes damaging of the associated valve or component.

Abstract: A combined pump-injector valve system utilizing a monolithic body to provide the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample. The pump-injector valve system further includes a pressure sensor external the barrel of the pump and may include an interim position intermediate loading and injection where the contents of the barrel may be pressurized to a desired pressure.

Abstract: A combined pump-injector valve utilizing a single piece as the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample.

Abstract: A combined dual pump-injector valve utilizing a single piece of material to house the barrel for each of the two piston-based pumps and to provide the stator of the associated valve, thus eliminating any need for connections between the pumps and the valve, and therefore eliminating the potential for high-pressure leaks or pressure reductions. The combined dual pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample.

Abstract: A heated rotary valve for use in connection with a sample to be separated in a column for heating the sample to temperature within the valve. The heated rotary valve permits introduction of compounds, having a wide boiling range, into a gas chromatograph with improved precision of area and retention time. The valve includes a stator, an elongate body, a rotor seal, a drive shaft, and an internal element for generating heat. The rotor seal may be laterally captured by a ring to prevent movement or creep due to heat absorption during operation.

Abstract: A detector for gas chromatography using two or more ionization sources within a single body to separately provide ionization energy to a column gas eluent to provide electrical discharge to two or more collecting electrodes provides improved selectivity and may be so used. Use is made of combined bias/collecting electrodes or of sets of separated bias and collecting electrodes. The use of multiple ionization sources permits generation of multiple detector outputs from within a common body and of a common constituent flow. The ionization sources and any applicable discharge gas and dopant may be selected based on desired selectivity.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a reservoir in fluid communication with the needle, positioned within the housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with the reservoir-connecting conduit, and a linear drive attached to the needle or to the needle-receiving member. The fluid drive impel fluids from the second reservoir to the reservoir-connecting conduit and thus drives the therapeutic agent from the reservoir during the linear displacement of the needle towards the housing. Fluid communication from the therapeutic agent reservoir to the needle is maintained by the tubing during operation of the linear drive.

Abstract: A heated rotary valve for use in connection with a sample to be separated in a column for heating the sample to temperature within the valve. The heated rotary valve permits introduction of compounds, having a wide boiling range, into a gas chromatograph with improved precision of area and retention time. The valve includes a stator, an elongate body, a rotor seal, a drive shaft, and an internal element for generating heat. The rotor seal may be laterally captured by a ring to prevent movement or creep due to heat absorption during operation.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body with zero pressure differential. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a therapeutic agent reservoir in fluid communication with the needle, positioned within said housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the therapeutic agent reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with said reservoir-connecting conduit, and a linear drive attached to said needle or to said needle-receiving member.

Abstract: A pulsed discharge helium ionization detector for gas chromatography with multiple combined bias/collecting electrodes.

Abstract: A minimally invasive method for drilling into bone and for providing for delivery of medical treatment is provided. The method includes use of a drilling system includes a miniature shaft, a bit, a guide tube encapsulating the shaft during drilling and a cortex adapter thereafter to prevent closure of the drilled hole, a stylet to prevent blockage of the resulting passage, and introduction for treatment following removal of the stylet. As a result, a hole, targeted towards a cancerous lesion within the bone, is possible.

Abstract: A detector for gas chromatography using two or more ionization sources within a single body to separately provide ionization energy to a column gas eluent to provide electrical discharge to two or more collecting electrodes provides improved selectivity and may be so used. Use is made of combined bias/collecting electrodes or of sets of separated bias and collecting electrodes. The use of multiple ionization sources permits generation of multiple detector outputs from within a common body and of a common constituent flow. The ionization sources and any applicable discharge gas and dopant may be selected based on desired selectivity.

Abstract: A combined dual pump-injector valve utilizing a single piece of material to house the barrel for each of the two piston-based pumps and to provide the stator of the associated valve, thus eliminating any need for connections between the pumps and the valve, and therefore eliminating the potential for high-pressure leaks or pressure reductions. The combined dual pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample.

Abstract: A minimally invasive and particularly small apparatus for drilling into bone and for providing for delivery of medical treatment is provided. The directional drilling apparatus includes a miniature shaft, a bit, first shaft-mounted thrust ring, second shaft-mounted thrust ring, a tubing jacket surrounding the shaft and intermediate the first and second shaft-mounted thrust rings, and a guide tube encapsulating the tubing jacket. As a result, a hole, targeted towards a cancerous lesion within the bone, is possible. After removal of the shaft and the tubing jacket, treatment may be introduced through the particularly small passage created by the directional drilling apparatus or through the passage via a capillary inserted through at least a portion of the guide tube and the passage, which guide tube may include a hypodermic needle.

Abstract: A detector for gas chromatography using two ionization sources within a single body to separately provide ionization energy to a column gas eluent to provide electrical discharge to two or more collecting electrodes provides improved selectivity and may be so used. Use is made of combined bias/collecting electrodes. The use of two ionization sources permits generation of two detector outputs from within a common body and of a common constituent flow. The ionization sources and any applicable discharge gas and dopant may be selected based on desired selectivity.