Abstract: A combined pump-injector valve utilizing a single piece as the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample.

Abstract: The adaptive temperature controller system includes a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at one or more temperatures and therefore determines the resistance of the material through a range of operating temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its temperature, are known. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.

Abstract: A detector for gas chromatography using two ionization sources within a single body to separately provide ionization energy to a column gas eluent to provide electrical discharge to two or more collecting electrodes provides improved selectivity and may be so used. Use is made of combined bias/collecting electrodes. The use of two ionization sources permits generation of two detector outputs from within a common body and of a common constituent flow. The ionization sources and any applicable discharge gas and dopant may be selected based on desired selectivity.

Abstract: The adaptive temperature controller system includes a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at one or more temperatures and therefore determines the resistance of the material through a range of operating temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its temperature, are known. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.

Abstract: A pulsed discharge helium ionization detector for gas chromatography with multiple combined bias/collecting electrodes.

Abstract: The adaptive temperature controller includes a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at one or more temperatures and therefore determines the resistance of the material through a range of operating temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its temperature, are known. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.

Abstract: A syringe which disperses medicate across a zone in the body during apparent conventional operation. The improved syringe includes a barrel, a plunger, and an operating cylinder. In operation, the needle of the syringe is inserted into the body at the distal portion of the portion of the body which is to receive the medicate. A single arm is attached to the barrel and passes through an operating cylinder with a thumb rest on its top. As a result, in operation, the user draws the single arm up to the thumb rest, thus causing the syringe to withdraw during injection and leaving a patch of medicate during operation.

Abstract: A minimally invasive method for drilling into bone and for providing for delivery of medical treatment is provided. The method includes use of a drilling system includes a miniature shaft, a bit, a guide tube encapsulating the shaft during drilling and a cortex adapter thereafter to prevent closure of the drilled hole, a stylet to prevent blockage of the resulting passage, and introduction for treatment following removal of the stylet. As a result, a hole, targeted towards a cancerous lesion within the bone, is possible.

Abstract: This invention provides a safer and more effective treatment for non-intracavitary undesirable tissue masses, especially bone cancer and soft tissue tumors. The method involves the direct administration of a therapeutically-effective dose of a formulated radioisotope composition nearby or directly into the tissue mass. Small volumes of the composition are used. Administration of the dose for bone cancer may be done through a hole or multiple holes created in the bone using a miniature drill. Delivery of the dose directly into a tumor may be accomplished using a microsyringe or a miniature pump capable of accurately delivering microliter amounts of material.

Abstract: A minimally invasive and particularly small system for drilling into bone) and for providing for delivery of medical treatment is provided. The drilling system includes a miniature shaft, a bit, a guide tube encapsulating the shaft during drilling and a capillary tube thereafter, a capillary tube, and a stylet. As a result, a hole, targeted towards a cancerous lesion within the bone, is possible. After removal of the shaft, the treatment may be introduced via the capillary tube after removal of the stylet.

Abstract: A dispensing device which disperses medicate through a needle across a zone within a body with zero pressure differential. The device includes a needle which is, during use, becomes encapsulated within a tubular needle-receiving member, a therapeutic agent reservoir in fluid communication with the needle, positioned within said housing, and in communication with the needle, a second reservoir, a reservoir-connecting conduit in communication with the therapeutic agent reservoir, a fluid drive in communication with the fluid in the second reservoir and in communication with said reservoir-connecting conduit, and a linear drive attached to said needle or to said needle-receiving member.

Abstract: A device for introduction of an ammonia dopant into a spectrometry system without the use of a delivery system containing ammonia. The delivery device includes an ammonium solid that will, upon the introduction of heat, yield ammonia gas for delivery into the spectrometer system. Use of such an alternative to traditional ammonia dopant systems will yield little or no change in spectrometer readings. The volumetric flow rate of the ammonium is controlled by the use of capillary tubes as the exiting pathway, where the flowrate is determined by the cross sectional area and length of the capillary tube. Delivery of the ammonia is aided by use of a frit or screen to permit only gas to exit.

Abstract: A minimally invasive and particularly small apparatus for drilling into bone and for providing for delivery of medical treatment is provided. The directional drilling apparatus includes a miniature shaft , a bit , first shaft-mounted thrust ring , second shaft-mounted thrust ring , a tubing jacket surrounding the shaft and intermediate the first and second shaft-mounted thrust rings, and a guide tube encapsulating the tubing jacket . As a result, a hole, targeted towards a cancerous lesion within the bone , is possible. After removal of the shaft and the tubing jacket , treatment may be introduced through the particularly small passage created by the directional drilling apparatus or through the passage via a capillary inserted through at least a portion of the guide tube and the passage , which guide tube may include a hypodermic needle .

Abstract: This invention provides a safer and more effective treatment for non-intracavitary undesirable tissue masses, especially bone cancer and soft tissue tumors. The method involves the direct administration of a therapeutically-effective dose of a formulated radioisotope composition nearby or directly into the tissue mass. Small volumes of the composition are used. Administration of the dose for bone cancer may be done through a hole or multiple holes created in the bone using a miniature drill. Delivery of the dose directly into a tumor may be accomplished using a microsyringe or a miniature pump capable of accurately delivering microliter amounts of material.

Abstract: A syringe which disperses medicate across a zone in the body during apparent conventional operation. The improved syringe includes a barrel, a plunger, and an operating cylinder. In operation, the needle of the syringe is inserted into the body at the distal portion of the portion of the body which is to receive the medicate. A single arm is attached to the barrel and passes through an operating cylinder with a thumb rest on its top. As a result, in operation, the user draws the single arm up to the thumb rest, thus causing the syringe to withdraw during injection and leaving a patch of medicate during operation.

Abstract: A device for introduction of an ammonia dopant into a spectrometry system without the use of a delivery system containing ammonia. The delivery device includes an ammonium solid that will, upon the introduction of heat, yield ammonia gas for delivery into the spectrometer system. Use of such an alternative to traditional ammonia dopant systems will yield little or no change in spectrometer readings. The volumetric flow rate of the ammonium is controlled by the use of capillary tubes as the exiting pathway, where the flowrate is determined by the cross sectional area and length of the capillary tube. Delivery of the ammonia is aided by use of a frit or screen to permit only gas to exit.

Abstract: A minimally invasive and particularly small system for drilling into bone) and for providing for delivery of medical treatment is provided. The drilling system includes a miniature shaft, a bit, a guide tube encapsulating the shaft during drilling and a capillary tube thereafter, a capillary tube, and a stylet. As a result, a hole, targeted towards a cancerous lesion within the bone, is possible. After removal of the shaft, the treatment may be introduced via the capillary tube after removal of the stylet.

Abstract: The adaptive temperature controller includes a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at one or more temperatures and therefore determines the resistance of the material through a range of operating temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its temperature, are known. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.

Abstract: The adaptive temperature controller includes an ambient temperature sensor, a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at or near ambient temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its instant temperature is known. Additionally, the adaptive temperature controller determines the responsiveness of the electrically-conductive material to determine the predicted increase in temperature and rate of increase in temperature relative to increases in voltage, current or power. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.

Abstract: The adaptive temperature controller includes an ambient temperature sensor, a device for measuring resistance, an electrically-conductive material, a power supply, and a device for controlling power. In operation, the controller determines the resistance of material at or near ambient temperature. Based on such determination so long as voltage and power are known, the resistance of the material, and therefore its instant temperature is known. Additionally, the adaptive temperature controller determines the responsiveness of the electrically-conductive material to determine the predicted increase in temperature and rate of increase in temperature relative to increases in voltage, current or power. As a result the voltage or power may be instantly varied to produce near infinite control over material temperature.