Abstract: A compound comprising a cyclopentanone, cyclopentenone, cyclohexanone or cyclohexenone group, wherein a first ring carbon atom carries an —SR substituent, R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group that, optionally, includes at least one heteroatom in its carbon skeleton, the remaining available ring carbon atoms are optionally substituted, and said compound either:—(a) is more soluble in water at a temperature of 20-40° C.; (b) is less lipophilic; and/or, (c) has a greater therapeutic index; or; (d) is less soluble in water at a temperature of 20-40° C.; (e) is more lipophilic; and/or, (f) has a greater therapeutic index; than an equivalent cyclohex-2-en-1-one or cyclopent-2-en-1-one derivative in which a hydrogen atom replaces said —SR group.

Abstract: A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen; X is —NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1-4 carbon atoms; when X is —NR4R5, R2 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; when X is R7, R2 is an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; R3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; R4 is hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl

Abstract: The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain poly unsaturated fatty acids.

Abstract: Compounds of formulae (I) or (II): wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton, and R?1 and R?2 are H, or an —OR?3 group in which R?3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group containing 4-12 carbon atoms, that optionally includes at least one heteroatom in its carbon skeleton, and R?1 and R?2 cannot both be H, and their use in therapeutic methods.

Abstract: Compounds of formula (I) or (II), wherein R is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton, and R1 is a substituted or unsubstituted, branched or straight chain alkyl, alkenyl, or alkynyl group, that contains 1-12 carbon atoms, and there use in therapeutic methods.

Abstract: A method of preparing prostanoid cross-conjugated dienones, via a tandem conjugate addition-Peterson olefination reaction route is described. Such compounds may be useful in medicine and other fields.

Abstract: There is provided a process for the addition of a nucleophile across an electron poor carbon-carbon double bond (a Michael addition) comprising contacting in a solvent: i) a nucleophile; ii) a compound comprising an electron poor double bond; and iii) a catalyst comprising a soluble polymer and a polyamino acid.

Abstract: A motorized roller comprised of a commercial electric motor suspended inside a drive roller tube, drives via belt means, input of a integral two stage drive belt system adjacent to said motorized drive roller. Subsequently the output of two stage drive belt system is fed back to the motorized motor outside housing which in turn drives treadmill or conveyor continuous belt to move people or goods. Increased torque provided by two stage drive requires less horsepower. The all belt, no gears, drive system absorbs shock, is quiet and has a low profile.

Abstract: There is provided a process for the addition of a nucleophile across an electron poor carbon-carbon double bond (a Michael addition) comprising contacting in a solvent: i) a nucleophile; ii) a compound comprising an electron poor double bond; and iii) a catalyst comprising a soluble polymer and a polyamino acid.

Abstract: A novel hose coupling for a liquid transfer system is provided. The coupling comprises a connector portion adapted to lockingly engage an adapter on a receptacle, such as a gas tank, and a handle portion. The handle is proximate to a releasing member which is oriented for manipulation by a hand holding the handle. The releasing member is moveable between a first engaged position in which the coupling is lockingly engaged with a receptacle adapter and a second disengaged position in which the coupling is released from locking engagement with the adapter. Accordingly, the coupling is disengaged from locking engagement with the adapter when the release member is displaced from the engaged position to the disengaged position. The coupling allows one-handed, ambidextrous use, providing a coupling operator with greater maneouverability which is advantageous particularly in instances where receptacle access is limited.

Abstract: A dart for the game of darts has mounting in the form of a bore (12) in the barrel (10, 31) which receives a stem part (13, 30, 44) of a point (13, 30) and/or of a shaft (44) with a flight (45). The stem part is gripped and retained by a spring clip (16) trapped in the bore (12). The stem may be rotatable or not in the bore. A second mounting may also be provided for receiving a threaded portion (43) of a dart shaft (32) or dart point (40). The dart can be provided with interchangeable points (13, 30, 40) and shafts (32, 44) which fit into either of the first and second mountings in dependence upon the point and shaft chosen.

Abstract: A dry disconnect coupling for connecting one fluid conduit to another fluid conduit to form a continuous flow path, the coupling including a receptacle and a coupler, each being secured to a respective conduit or container. The receptacle and the coupler are secured and locked together to provide a connection for transfer of fluids. A poppet valve is provided and seated in each of the receptacle and the coupler for sealing a respective flow passageway therein when the coupling is uncoupled. The receptacle poppet valve and the coupler poppet valve can be unseated to permit flow of fluid through the coupling when the coupling is coupled and locked. The poppet valve of the receptacle has resilient annular seal member in its poppet sealing surface.

Abstract: A protective garment 10 for a limb, such as a limb of a horse, includes a covering 12 configured and dimensioned to wrap at least part way around the limb. A remoulded thermoplastic sheet 14 is retained within the covering 12. The covering 12 includes a front sheet 20 and a back sheet 22 which are fastened together about their periphery by a ribbon 24. The back sheet 22 is of a smaller size and the front sheet 20 is made of an elastic material. As a result, the bulk sheet 22 is in a stretched state when the garment 10 is unwrapped. When the garment 10 is applied to a limb, the back sheet 22 contracts onto the limb to form a substantial seal to prevent ingress of foreign material including water. The thermoplastic sheet 14 can be remoulded insitu, to a shape complimentary to a portion of the limb over which it is disposed. A foam sheet 28 is placed between the thermoplastic sheet 14 and back sheet 22 to provide improved cushioning and comfort.

Abstract: An apparatus for producing laminated integrated circuit cubes includes a hermetically sealable oven chamber. At least one conductive heating device is used to heat the cube to a cure temperature. A vacuum source is connected to the oven chamber to remove gas from between the integrated circuit layers prior to curing. A press device applies pressure to the cube while it is heated under vacuum. A cooling gas is circulated through the oven chamber after curing. A cooling fluid can also be circulated through cooling channels in at least one wall of the oven chamber to cool the chamber.

Abstract: This invention relates to an automatic shut-off valve arrangement for use in fluid transfer systems. In particular, the valve arrangement or assembly may be mounted in a fluid tank or other type of fluid containment zone to automatically shut off flow from a source, when the desired volume of fill is reached. The assembly is for use in automatic or semi-automatic fluid handling systems which include specialized nozzles and coupling systems which eliminate spillage in the process of connection and disconnection of the nozzle and the tank inlet.

Abstract: A cap and cap arrangement for covering a necked opening preferably for use with fuel tank fill racks, the cap arrangement comprising: a cap, the cap having an open and a closed position; flexible retaining means for securing the cap to the neck in proximity to the opening, the flexible retaining means extending between the cap and the neck and arranged to provide a non-fixed pivot point in a plane laterally spaced from the cap and neck so that the cap pivots between its open and closed positions, and the cap having internal spring means positioned to engage the necked opening with sufficient tension to retain the cap in its closed position but to permit easy withdrawal of the cap upon application of suitable pressure to the cap.

Abstract: A method for producing laminated integrated circuit cubes includes applying conductive heat to the cube using at least one conductive heating device. A vacuum is created around the cube to remove air and other gases from between the integrated circuit layers prior to curing. A force is applied to the cube while it is heated under vacuum. A cooling gas is then circulated over the cube. Temperature and force sensing can be performed, and the process can be controlled by programmable logic controllers and the like.

Abstract: An oven for making laminated integrated circuit cubes includes an oven chamber with at least one access opening. A closure member for the access opening is capable of hermetically sealing the chamber. A hermetic connection is provided for supplying power to within the chamber. Structure permits the withdrawal of air and other gases from within the chamber. Hermetic structure permits the application of a press force to a workpiece within the chamber from an actuator outside the chamber. Hermetic temperature sensing devices measure the temperature of a workpiece within the chamber.