Patents by Inventor Stefaan Julien Last

Stefaan Julien Last has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC SUBSTITUTED 2-AMINO QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170349557
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: May 10, 2017
    Publication date: December 7, 2017
    Inventors: Stefaan Julien LAST, David Craig MC GOWAN, Werner EMBRECHTS, Serge Maria Aloysius PIETERS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • Substituted acylaminopyrimidines as inducers of alpha interferon production
    Patent number: 9790191
    Abstract: This invention relates to acylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: October 17, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: David Craig Mc Gowan, Serge Marie Aloysius Pieters, Werner Embrechts, Stefaan Julien Last, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20170239245
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Application
    Filed: July 13, 2016
    Publication date: August 24, 2017
    Inventors: David Mc GOWAN, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • Heterocyclic substituted 2-amino quinazoline derivatives for the treatment of viral infections
    Patent number: 9663474
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: May 30, 2017
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Stefaan Julien Last, David Craig McGowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases
    Publication number: 20170044169
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: October 25, 2016
    Publication date: February 16, 2017
    Inventors: David Craig Mc Gowan, Stefaan Julien Last, Serge Maria Aloysius Pieters, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20170002025
    Abstract: Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: June 28, 2016
    Publication date: January 5, 2017
    Inventors: Sandrine Marie Helene VENDEVILLE, Stefaan Julien LAST, Samuël Dominique DEMIN, Sandrine Céline GROSSE, Geerwin Yvonne Paul HACHÉ, Lili HU, Serge Maria Aloysius PIETERS, Geert ROMBOUTS, Koen VANDYCK, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20160347741
    Abstract: Inhibitors of HBV replication of Formula (A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R5 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: February 5, 2015
    Publication date: December 1, 2016
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • BENZIMIDAZOLE-IMIDAZOLE DERIVATIVES
    Publication number: 20160340344
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R? are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
    Type: Application
    Filed: August 4, 2016
    Publication date: November 24, 2016
    Inventors: Koen Vandyck, Stefaan Julien Last, Ioannis Nicolaos Houpis, Pierre Jean-Marie Bernard Raboisson
  • Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases
    Patent number: 9499549
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: November 22, 2016
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: David Craig McGowan, Stefaan Julien Last, Serge Maria Aloysius Pieters, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Benzimidazole-imidazole derivatives
    Patent number: 9433609
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R? are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 6, 2016
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Stefaan Julien Last, Ioannis Nicolaos Houpis, Pierre Jean-Marie Bernard Raboisson
  • Benzimidazole-imidazole derivatives
    Patent number: 9427428
    Abstract: Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R? are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: August 30, 2016
    Assignee: Janssen Sciences Ireland UC
    Inventors: Koen Vandyck, Stefaan Julien Last, Ioannis Nicolaos Houpis, Pierre Jean-Marie Bernard Raboisson
  • Pyrimidine derivatives for the treatment of viral infections
    Patent number: 9422250
    Abstract: This invention relates to pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections such as HCV or HBV.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: August 23, 2016
    Assignee: Janssen Sciences Ireland UC
    Inventors: David Mc Gowan, Pierre Jean-Marie Bernard Raboisson, Werner Embrechts, Tim Hugo Maria Jonckers, Stefaan Julien Last, Serge Maria Aloysius Pieters, Jaromir Vlach
  • PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
    Publication number: 20160168150
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Application
    Filed: June 26, 2014
    Publication date: June 16, 2016
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: David Craig MC GOWAN, Serge Maria Aloysius PIETERS, Stefaan Julien LAST, Werner EMBRECHTS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON
  • SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20160115125
    Abstract: Inhibitors of HBV replication of Formula (ID) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, Ra to Rd and R4 to R6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: May 16, 2014
    Publication date: April 28, 2016
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, David Craig MC GOWAN, Geert ROMBOUTS, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20160115149
    Abstract: Inhibitors of HBV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R1 to R8 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: May 16, 2014
    Publication date: April 28, 2016
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen VANDYCK, Geerwin Yvonne Paul HACHÉ, Stefaan Julien LAST, Wim Gaston VERSCHUEREN, Pierre Jean-Marie Bernard RABOISSON
  • N-PHENYL-CARBOXAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20160051512
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X, R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: April 2, 2014
    Publication date: February 25, 2016
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen Vandyck, Geerwin Yvonne Paul Haché, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20160002155
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, salts, hydrates and solvates thereof, wherein R1, R2, R3 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Applicant: JANSSEN SCIENCES IRELAND UC
    Inventors: Koen Vandyck, Stefaan Julien Last, Pierre Jean-Marie Bernard Raboisson
  • HETEROCYCLIC SUBSTITUTED 2-AMINO QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20150284339
    Abstract: This invention relates to heterocyclic substituted 2-amino-quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: November 15, 2013
    Publication date: October 8, 2015
    Inventors: Stefaan Julien Last, David Craig Mc Gowan, Werner Embrechts, Serge Maria Aloysius Pieters, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • ACYLAMINOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
    Publication number: 20150274676
    Abstract: This invention relates to acylaminopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: October 3, 2013
    Publication date: October 1, 2015
    Inventors: David Craig Mc Gowan, Serge Marie Aloysius Pieters, Werner Embrechts, Stefaan Julien Last, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • SULFAMOYL-ARYLAMIDES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
    Publication number: 20150274653
    Abstract: Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R1, R2 and R4 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
    Type: Application
    Filed: August 28, 2013
    Publication date: October 1, 2015
    Inventors: Koen Vandyck, Stefaan Julien Last, Geert Rombouts, Wim Gaston Verschueren, Pierre Jean-Marie Bernard Raboisson