Abstract: The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

Abstract: The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein Rx, Ry, Rz and Rzz are selected from: a) Rx and Ry are F and Rz and Rzz are H; b) Rx, Ry and Rzz are independently halogen and Rz is H; c) Rx Rz and Rzz are independently halogen and Ry is H; and d) Rx Ry and Rz are independently halogen and Rzz is H.

Abstract: A conveyor device for conveying an object with an identification device. The conveyor device comprises a plurality of rollers, connected drive motors for driving the rollers, a transmitter, a receiver for detecting the distance of the identification device and a control device for controlling the connected drive motors.

Abstract: An adapter for receiving at least one integrated circuit with a Hall sensor in a housing. The adapter has a cavity for receiving the at least one integrated circuit in the housing, at least one opening connected with the cavity, and a magnetic-field generating apparatus for generating a magnetic field in the cavity. The adapter is used in a system for detecting the strength of a magnetic field.

Abstract: A measuring system and drive system with a measuring system, a magnet, a transmitter, and a magnetic field sensor. The magnetic field sensor is arranged between the magnet and the transmitter. The transmitter has a number of segments made of a magnetically conductive material, each segment having a wing shape with a web edge that is radially directed outwards, each web edge being diagonally designed towards the rotational direction, and that each web edge is distanced from the magnetic field sensor by an air gap.

Abstract: A conveyor device for conveying an object with an identification device. The conveyor device comprises a plurality of rollers, connected drive motors for driving the rollers, a transmitter, a receiver for detecting the distance of the identification device and a control device for controlling the connected drive motors.

Abstract: A monitoring system having a monitoring unit and a circuit element that are integrated in an enclosure for protecting connections between the monitoring unit and the circuit element. The monitoring unit monitors the circuit element via a first electrical quantity, and the monitoring unit has a control unit and a first circuit unit and a second circuit unit. The first current is essentially or precisely equal in amplitude to the first current, and the first current and the second current flow simultaneously in the two line sections. The first current direction is opposite to the second current direction, and the first circuit unit ascertains a first voltage drop at the first line section, and the second circuit unit ascertains a second voltage drop at the second line section. The control unit ascertains the first electrical quantity from the first voltage drop and the second voltage drop.

Abstract: A magnetic field measuring device having a semiconductor body with a surface parallel to an x-y plane and having a magnet with a flat main extension surface parallel to the x-y plane, the direction of magnetization changes along the main extension surface due to at least two adjacent magnetic poles, the magnet being rotatable relative to the IC package about an axis of rotation extending in a z direction and the z direction being orthogonal to the x-y plane. An imaginary extension of the axis of rotation passes through the magnet. The semiconductor body has three magnetic field sensors spaced apart from one another on the surface, and each of the magnetic field sensors measures the same component of the magnetic field. All magnetic field sensors are located along the imaginary extension of the axis of rotation within the projection of the main extension surface.

Abstract: An adapter for receiving at least one integrated circuit with a Hall sensor in a housing. The adapter has a cavity for receiving the at least one integrated circuit in the housing, at least one opening connected with the cavity, and a magnetic-field generating apparatus for generating a magnetic field in the cavity. The adapter is used in a system for detecting the strength of a magnetic field.

Abstract: A device used to achieve a releasable connection between two components and at least one shaft on which the components are rotatably mounted. A switching element that is mounted on the shaft can be coupled to one of the components in a non-rotatable fashion by relative motion in the axial direction of the shaft between the components and the switching element. Toothing profiles of the components each comprise at least two spaced-apart teeth rows. A toothing profile of the switching element is provided with at least three spaced-apart rows of teeth, of which at least two teeth rows of the switching element can be brought into a position where they overlap/engage with the two teeth rows of the first component and also where this happens for at least two of the three teeth rows of the switching element with the two teeth rows of the second component.

Abstract: A bridge circuit with improved fail-safety, having a first electrical load with a first contact terminal and a second contact terminal, and a first series circuit connected to a first node and to a second node. A second series circuit is connected to a third node and to a fourth node. A third series circuit is connected to the second node and to a fifth node. A fourth series circuit is connected to the fourth node and to a sixth node. The first node and the third node are connected to a supply voltage, and the fifth node and the sixth node are connected to a reference voltage, and the first contact terminal is connected to the second node and the second contact terminal is connected to the fourth node.

Abstract: A measuring system and drive system with a measuring system, a magnet, a transmitter, and a magnetic field sensor. The magnetic field sensor is arranged between the magnet and the transmitter. The transmitter has a number of segments made of a magnetically conductive material, each segment having a wing shape with a web edge that is radially directed outwards, each web edge being diagonally designed towards the rotational direction, and that each web edge is distanced from the magnetic field sensor by an air gap.

Abstract: A magnetic field measuring device having a semiconductor body with a surface parallel to an x-y plane and having a magnet with a flat main extension surface parallel to the x-y plane, the direction of magnetization changes along the main extension surface due to at least two adjacent magnetic poles, the magnet being rotatable relative to the IC package about an axis of rotation extending in a z direction and the z direction being orthogonal to the x-y plane. An imaginary extension of the axis of rotation passes through the magnet. The semiconductor body has three magnetic field sensors spaced apart from one another on the surface, and each of the magnetic field sensors measures the same component of the magnetic field. All magnetic field sensors are located along the imaginary extension of the axis of rotation within the projection of the main extension surface.

Abstract: A method for producing an endless transport belt for guiding substrates during the printing operation of a printing press is disclosed. The ends of a transport belt are welded together. The transport belt is ground, after one or multiple welding operations without or with the addition of material, to a nominal thickness that is smaller than or equal to the minimal thickness of the transport belt.

Abstract: A connecting device (1) for the rotationally fixed connection of first and second shafts (2, 3) that can rotate relative to one another. The connecting device (1) comprises an axially movable connecting element (5) designed such that, in a first axial position (A), the connecting element (5) forms an interlock between the first and second shafts (2, 3) and, in a second axial position (B), the connecting element (5) releases the interlock. The connecting device (1) also comprises an actuating system (6, 8, 9, 10, 11) for moving the connecting element between the first and second axial positions (A, B) and a stop (16) which limits the axial movement of the connecting element (5) in the first or second axial position (A, B). An impact damper (17) is provided for the stop (16) in order to reduce annoying noise when the connecting element (5) strikes against the stop (16).

Abstract: A printing press with at least one gripperless printing unit of a reel-fed printing press, through which a substrate to be printed can be transported in the horizontal direction by a transport device. A dimensionally stable and relatively stiff piece good, which during the transport and printing does not adapt to cylinder contours of the printing units, can be transported through the or each gripperless printing unit by the transport device. The printing press further includes a feeder, which keeps the piece good to be printed ready and via which the piece good to be printed can be circumference register-precisely and page register-precisely placed on the transport device for the subsequent printing in the printing units.

Abstract: A device used to achieve a releasable connection between two components and at least one shaft on which the components are rotatably mounted. A switching element that is mounted on the shaft can be coupled to one of the components in a non-rotatable fashion by relative motion in the axial direction of the shaft between the components and the switching element. Toothing profiles of the components each comprise at least two spaced-apart teeth rows. A toothing profile of the switching element is provided with at least three spaced-apart rows of teeth, of which at least two teeth rows of the switching element can be brought into a position where they overlap/engage with the two teeth rows of the first component and also where this happens for at least two of the three teeth rows of the switching element with the two teeth rows of the second component.

Abstract: A monitoring system having a monitoring unit and a circuit element that are integrated in an enclosure for protecting connections between the monitoring unit and the circuit element. The monitoring unit monitors the circuit element via a first electrical quantity, and the monitoring unit has a control unit and a first circuit unit and a second circuit unit. The first current is essentially or precisely equal in amplitude to the first current, and the first current and the second current flow simultaneously in the two line sections. The first current direction is opposite to the second current direction, and the first circuit unit ascertains a first voltage drop at the first line section, and the second circuit unit ascertains a second voltage drop at the second line section. The control unit ascertains the first electrical quantity from the first voltage drop and the second voltage drop.

Abstract: A method for controlling at least one control parameter from a number of parameters of an inking unit of a printing press is disclosed. Based on at least the control parameter, a value of an ink density on a substrate to be printed by the printing press is calculated by an inking unit model and the calculated value is used as input quantity for controlling instead of an actual value. Here, the calculated value is exclusively calculated based on a number of parameters of the inking unit at least at times.

Abstract: A resilient inflatable delineator pole. The delineator pole can include an elongated body enclosing an interior chamber, a flap disposed at a bottom end of the body and having an aperture defined therein, a retention structure for retaining a lower portion of the body within a granular medium, at least one valve disposed on the elongated body and in communication with the interior chamber, and a protective sleeve enclosing a portion of the elongated body.