Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.

Abstract: The present invention generally relates to the field of fermentation technology and microorganisms useful for such fermentations. The invention also relates to materials including nucleic acids and proteins useful for altering fermentation characteristics of microorganisms, and to microorganisms comprising such nucleic acids and/or proteins.

Abstract: A gangway bellow includes an outer bellow presenting corrugations forming a plurality of valleys presenting each a valley top portion facing upwardly and connected at each end to a valley top corner forming a junction between the valley top portion and a respective bellow side. The gangway bellow further includes at least one drainage channel so that liquid accumulating into at least one of the valley top portions flows through the at least one drainage channel along the respective bellow side.

Abstract: An X-ray detector unit is disclosed. In an embodiment, the X-ray detector unit includes: at least one analysis unit to process electrical signals delivered from a coupled converter unit and operatable by an operating voltage; an adjustable voltage supply, coupled to the at least one analysis unit, to provide an adjustable supply voltage; an identification unit, assigned to the at least one analysis unit, to provide identification information about the at least one analysis unit in a readable manner; and a communication unit, coupled to the adjustable voltage supply, to read the identification information provided from the identification unit, and based upon the identification information provided, to adjust the adjustable voltage supply to equate the provided supply voltage to the operating voltage of the at least one analysis unit.

Abstract: A gangway bellow includes an outer bellow presenting corrugations forming a plurality of valleys presenting each a valley top portion facing upwardly and connected at each end to a valley top corner forming a junction between the valley top portion and a respective bellow side. The gangway bellow further includes at least one drainage channel so that liquid accumulating into at least one of the valley top portions flows through the at least one drainage channel along the respective bellow side.

Abstract: An X-ray detector unit is disclosed. In an embodiment, the X-ray detector unit includes: at least one analysis unit to process electrical signals delivered from a coupled converter unit and operatable by an operating voltage; an adjustable voltage supply, coupled to the at least one analysis unit, to provide an adjustable supply voltage; an identification unit, assigned to the at least one analysis unit, to provide identification information about the at least one analysis unit in a readable manner; and a communication unit, coupled to the adjustable voltage supply, to read the identification information provided from the identification unit, and based upon the identification information provided, to adjust the adjustable voltage supply to equate the provided supply voltage to the operating voltage of the at least one analysis unit.

Abstract: A detector apparatus for use as part of a data network includes a plurality of x-ray detectors, each of the plurality of x-ray detectors including a network-capable network interface, and a switch or router, connected to each of the network-capable network interfaces of the plurality of x-ray detectors, each of the plurality of x-ray detectors including a distinct IP address such that the data network is adjustable to take a change in a number of the plurality of x-ray detectors into account. The plurality of x-ray detectors are configured to detect x-rays generated from a single x-ray source.

Abstract: A method is disclosed for operating an x-ray device, in particular a computed tomograph, including a controller and a number of detector units coupled thereto for signaling purposes. Each of the detectors includes a functional unit and a number of detector elements coupled thereto. In an embodiment of the method, a synchronized clock signal for activating the detector elements is created from a control signal of the controller on the functional unit side.

Abstract: A detector apparatus for use as part of a data network includes a plurality of x-ray detectors, each of the plurality of x-ray detectors including a network-capable network interface, and a switch or router, connected to each of the network-capable network interfaces of the plurality of x-ray detectors, each of the plurality of x-ray detectors including a distinct IP address such that the data network is adjustable to take a change in a number of the plurality of x-ray detectors into account. The plurality of x-ray detectors are configured to detect x-rays generated from a single x-ray source.

Abstract: A detector apparatus includes at least one x-ray detector, including a network-capable network unit; and a switching unit connected to the network unit of the x-ray detector.

Abstract: A detector facility for a medical imaging system is described. The detector facility has a plurality of individual detectors and at least one detector controller. The detector facility is embodied such that it can be switched to at least one power-saving mode, in which at least one portion of the components of the individual detectors is deactivated and concurrently at least one portion of the components of the detector controller is not deactivated. A medical imaging system, in particular a computed tomography system, having such a detector facility; and a corresponding method for operating a detector facility of a medical imaging system are also described.

Abstract: Techniques of joining imperfectly-matching NURBS patches to form a computerized model suitable for FEA are disclosed. Definitions of first and second patches are received for joining together along a physical boundary defined in first and second curves that are imperfectly-matching. Both curves' knot-vectors are normalized such that the parametric length equals the physical length, respectively. The curve having less number of control points is designated as master curve, the other as slave curve. If the curves are partially overlapped the first and second curves are adjusted such that first and second projection points correspond to starting and end locations of the common curve, respectively A set of linear constraint equations for numerically connecting the patches along the physical boundary by computing dependencies of the slave curve's control points to the master curve's control points. The patches together with the constraint equations enable a computerized model created therefrom suitable for FEA.

Abstract: A detector apparatus includes at least one x-ray detector, including a network-capable network unit; and a switching unit connected to the network unit of the x-ray detector.

Abstract: A method is disclosed for operating an x-ray device, in particular a computed tomograph, including a controller and a number of detector units coupled thereto for signaling purposes. Each of the detectors includes a functional unit and a number of detector elements coupled thereto. In an embodiment of the method, a synchronized clock signal for activating the detector elements is created from a control signal of the controller on the functional unit side.

Abstract: A detector facility for a medical imaging system is described. The detector facility has a plurality of individual detectors and at least one detector controller. The detector facility is embodied such that it can be switched to at least one power-saving mode, in which at least one portion of the components of the individual detectors is deactivated and concurrently at least one portion of the components of the detector controller is not deactivated. A medical imaging system, in particular a computed tomography system, having such a detector facility; and a corresponding method for operating a detector facility of a medical imaging system are also described.

Abstract: It is desirable to produce live vaccines, which are highly attenuated and which do only contain minimal or no animal-derived components. The production of highly attenuated live viruses can be better achieved when using specifically designed cell lines as producer substrate as opposed to using less defined primary cells. However, live viruses, thus produced comprise undesirable components from the cell lines and cell culture. The present invention relates to methods of production and purification of live enveloped viruses, which are suitable for vaccination.

Abstract: A method is disclosed for transmission of register contents of a CT detector with hierarchical hardware structure, wherein the first hierarchy level is formed by a control unit containing a register table for the read-out register contents of FPGAs lying lower down in the hierarchy and an intermediate register store for register contents to be written. With each new reading, the new register contents for FPGAs lying lower down in the hierarchy arriving during the respective preceding reading from the central control at the control unit are forwarded to the next hierarchy level. With each new reading, the register contents of all FPGAs lying lower down in the hierarchy are re-entered into the register table of the control unit. Finally, in the event of a readout command transferred asynchronously from the central control, the register contents are read out exclusively from the register table.

Abstract: Techniques of joining imperfectly-matching NURBS patches to form a computerized model suitable for FEA are disclosed. Definitions of first and second patches are received for joining together along a physical boundary defined in first and second curves that are imperfectly-matching. Both curves' knot-vectors are normalized such that the parametric length equals the physical length, respectively. The curve having less number of control points is designated as master curve, the other as slave curve. If the curves are partially overlapped the first and second curves are adjusted such that first and second projection points correspond to starting and end locations of the common curve, respectively A set of linear constraint equations for numerically connecting the patches along the physical boundary by computing dependencies of the slave curve's control points to the master curve's control points. The patches together with the constraint equations enable a computerized model created therefrom suitable for FEA.

Abstract: A method is disclosed for transmission of register contents of a CT detector with hierarchical hardware structure, wherein the first hierarchy level is formed by a control unit containing a register table for the read-out register contents of FPGAs lying lower down in the hierarchy and an intermediate register store for register contents to be written. With each new reading, the new register contents for FPGAs lying lower down in the hierarchy arriving during the respective preceding reading from the central control at the control unit are forwarded to the next hierarchy level. With each new reading, the register contents of all FPGAs lying lower down in the hierarchy are re-entered into the register table of the control unit. Finally, in the event of a readout command transferred asynchronously from the central control, the register contents are read out exclusively from the register table.

Abstract: It is desirable to produce live vaccines, which are highly attenuated and which do only contain minimal or no animal-derived components. The production of highly attenuated live viruses can be better achieved when using specifically designed cell lines as producer substrate as opposed to using less defined primary cells. However, live viruses, thus produced comprise undesirable components from the cell lines and cell culture. The present invention relates to methods of production and purification of live enveloped viruses, which are suitable for vaccination.