Abstract: The present invention relates to compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear ?-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.

Abstract: The present invention relates to compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear ?-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.

Abstract: The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear ?-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.

Abstract: The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.

Abstract: The present invention relates to compounds of formula (I), to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy: Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway and increased presence of nuclear ?-catenin. For example, these may be used in preventing and/or retarding proliferation of tumor cells and metastasis, for example carcinomas such as colon carcinomas.

Abstract: A method produces a casting, in particular a housing of a turbocharger. Wherein at least one mold part for forming the casting has a respective parting plane which is arranged at a predetermined angle with respect to the longitudinal axis of the casting, and wherein at least one core element is provided.

Abstract: A radial compressor, in particular for a turbo-charger, has a spiral housing and a diffuser. The diffuser is constructed such that a low-pressure region in the area of the transition between the spiral housing and the tongue is at least reduced.

Abstract: The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.

Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.

Abstract: A turbocharger, which is particularly suitable for a motor vehicle, includes: a rotor shaft with a turbine impeller and a compressor impeller disposed thereon. The rotor shaft has a roller bearing assembly for mounting in the housing of the turbocharger.

Abstract: A turbocharger has a rotor housing. Said rotor housing has an insertion element. Said insertion element is configured such that the same forms an over-hanging spiral together with said rotor housing.

Abstract: A turbocharger has a wastegate duct that can be opened and closed by way of an actuator. The actuator encompasses a closing element that can be pivoted into the wastegate duct to close the same. This allows the required closing force, and hence also the size of the required actuator, to be reduced.

Abstract: A turbocharger has a turbocharger housing and a through opening for a shaft. The shaft is pivotally supported in the housing by way of a bearing arrangement. Lubricating oil is supplied for lubricating the bearings. A section of the shaft is provided on the outside of at least one bearing, the section forming a gap together with the housing. The gap is configured as a lubricating oil regulator in order to at least reduce a passage of lubricating oil from the sides of the bearing.

Abstract: A turbocharger has a turbocharger housing with a bearing housing and at least one impeller housing. The bearing housing and the impeller housing are screwed together by way of a screw anchor connection, and at least one head of an anchor of the screw anchor connection is covered by a cover element.

Abstract: A radial compressor, in particular for a turbo-charger, has a spiral housing and a diffuser. The diffuser is constructed such that a low-pressure region in the area of the transition between the spiral housing and the tongue is at least reduced.

Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.

Abstract: An axial bearing for a turbocharger contains a through hole for a shaft and at least one at least partially or completely circulating segment section on a first and second side of the axial bearing. At least one bearing surface is disposed in the segment section. At least one oil pocket is on the first side of the axial bearing. The oil pocket is connected to at least one recess opening outwards, the recess being configured such that it connects the oil pocket for oil supply purposes to the respective segment section and the bearing surface(s) thereof on the first and second side of the axial bearing.

Abstract: A turbocharger for a motor vehicle has a compressor housing, a turbine housing, a bearing housing, and at least one flange on the compressor side. The turbine housing is force-locked with the bearing housing by way of a fastening element that is arranged on the flange on the compressor side, thereby allowing the complete automatic assembly of the turbocharger.

Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.

Abstract: Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed.