Patents by Inventor Stefan Miller

Stefan Miller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW ENDOLYSIN OBPGPLYS
    Publication number: 20120189608
    Abstract: The present invention relates to a polypeptide with an amino acid sequence according to SEQ ID NO: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the N- or C-terminus. Moreover, the present invention relates to nucleic acid molecules encoding said polypeptide or fusion protein, vectors comprising said nucleic acid molecules and host cells comprising either said nucleic acid molecules or said vectors. In addition, the present invention relates to said polypeptide or fusion protein for use as a medicament, in particular for the treatment or prevention of Gram-negative bacterial infections, as diagnostic means, as cosmetic substance or as sanitizing agent.
    Type: Application
    Filed: August 24, 2010
    Publication date: July 26, 2012
    Inventors: Yves Briers, Rob Lavigne, Maarten Walmagh, Stefan Miller
  • NEW BACTERIOPHAGE ADHESION PROTEINS
    Publication number: 20120122124
    Abstract: The present invention relates to bacteriophage adhesion proteins binding to the O-antigen of gram negative bacteria, lacking the ability of binding to a bacteriophage and of hydrolysing lipopolysaccharides. The invention further relates to nucleic acid molecules comprising a sequence encoding the proteins according to the present invention. In addition, the present invention relates to a method for generating bacteriophage adhesion proteins according to the present invention. The invention further relates to the use of said proteins and methods of detection, purification and enrichment of bacteria.
    Type: Application
    Filed: July 3, 2009
    Publication date: May 17, 2012
    Inventors: Manfred Biebl, Renate Grassl, Monika Walter, Stefan Miller
  • Detection and identification of groups of bacteria
    Patent number: 8124355
    Abstract: The present invention concerns a method for the simultaneous detection of different bacteria, comprising the following steps: coupling one or more species of bacteriophage tail proteins onto a support, incubating the support coupled with the bacteriophage tail proteins with a sample, optionally removing the sample and the bacteria of the sample not bound to the bacteriophage tail proteins, contacting the bacteria bound to the bacteriophage tail proteins with the bacteriophages and/or bacteriophage proteins specifically binding the bacteria to be detected, removing the bacteriophages and/or bacteriophage proteins not bound to the bacteria, and performing the detection reaction by means of an enzyme coupled to the specifically binding bacteriophages and/or bacteriophage proteins or by means of an immuno assay.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: February 28, 2012
    Assignee: Biomerieux S.A.
    Inventor: Stefan Miller
  • Method For Detecting And Removing Endotoxin
    Publication number: 20110306068
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: July 12, 2011
    Publication date: December 15, 2011
    Applicant: HYGLOS INVEST GMBH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • Method for detecting and removing endotoxin
    Patent number: 8003313
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Grant
    Filed: January 23, 2006
    Date of Patent: August 23, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Grallert
  • ENDOTOXIN DETECTION METHOD
    Publication number: 20110053188
    Abstract: The invention relates to a method for detecting endotoxins in a sample.
    Type: Application
    Filed: December 20, 2004
    Publication date: March 3, 2011
    Applicant: HYGLOS INVEST GMBH
    Inventors: Roman Meyer, Michael Schütz, Holger Grallert, Renate Grassl, Stefan Miller
  • Method for unspecific enrichment of bacterial cells
    Patent number: 7868144
    Abstract: The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: January 11, 2011
    Assignee: Hyglos Invest GmbH
    Inventors: Sabine Diller, Renate Grassl, Stefan Miller, Ingrid Robl, Michael Schütz, Thomas Zander
  • Method for detecting and for removing endotoxin
    Patent number: 7858299
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Grant
    Filed: July 28, 2009
    Date of Patent: December 28, 2010
    Assignee: Hyglos Invest GmbH
    Inventors: Michael Schütz, Roman Meyer, Holger Grallert, Stefan Miller
  • Method and Means for Enrichment, Removal and Detection of Gram-Positive Bacteria
    Publication number: 20100092968
    Abstract: The present invention relates to polypeptides comprising a enzymatically non-active cell wall binding domain of an endolysin or another cell wall lysing enzyme, and a sequence according to SEQ ID NO: 1 or derivatives thereof, wherein the polypeptide besides the cell wall binding domain comprises no further domains of an endolysin, as well as means for their preparation. The present invention further relates to methods for binding, enriching, removing from a sample, capturing and/or detecting bacteria, particularly gram positive bacteria.
    Type: Application
    Filed: December 21, 2007
    Publication date: April 15, 2010
    Inventors: Martina Beissinger, Stefan Miller, Anja Philipp, Michael Schutz
  • Methods for purification of bacterial cells and cell components
    Publication number: 20100047895
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Application
    Filed: July 28, 2009
    Publication date: February 25, 2010
    Applicants: Hyglos Invest GmbH, bioMerieux S.A.
    Inventors: Michael Schütz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Method for Detecting and for Removing Endotoxin
    Publication number: 20100028857
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Application
    Filed: July 28, 2009
    Publication date: February 4, 2010
    Applicant: PROFOS AG
    Inventors: Michael Schütz, Roman Meyer, Holger Grallert, Stefan Miller
  • Method for identifying and for extracting endotoxin
    Patent number: 7585620
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: September 8, 2009
    Assignee: Profos AG
    Inventors: Michael Schütz, Roman Meyer, Holger Grallert, Stefan Miller
  • Methods for purification of bacterial cells and components
    Patent number: 7579142
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: August 25, 2009
    Assignee: Profos AG
    Inventors: Michael Schütz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Method For Detecting And Removing Endotoxin
    Publication number: 20090017445
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: January 23, 2006
    Publication date: January 15, 2009
    Applicant: PROFOS AG
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Graller
  • Foundation layer for services based enterprise software architecture
    Publication number: 20070233728
    Abstract: Methods and apparatus, including systems and computer program products, for a services architecture design that provides enterprise services having foundation layer functionality at the level of an enterprise application. The design includes a set of service operations, process components, and optionally deployment units. Suitable business objects are also described.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 4, 2007
    Inventors: Joachim Puteick, Martin Rogge, Hendrik Geipel, Andrea Pluemper, Andreas Huppert, Kai-Uwe Pielka, Ashwin Yeddula, Matthias Schmitt, Toralf Grossmann, Andreas Neumann, Bare Said, Stefan Miller, Michael Neumann, Florian Rehfeld, Ingo Bruss, Horst Schaude, Michael Bauer, Andreas Morsch, Silke Storch, Klaus Bahr, Bernd Schmitt, Michael Meyringer, Dirk Henrich
  • Detection and identification of bacterial strains
    Publication number: 20070042357
    Abstract: The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
    Type: Application
    Filed: May 31, 2006
    Publication date: February 22, 2007
    Inventor: Stefan Miller
  • Detection and identification of bacterial strains
    Patent number: 7087376
    Abstract: The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: August 8, 2006
    Assignee: Profos AG
    Inventor: Stefan Miller
  • Method for identifying and for extracting endotoxin
    Publication number: 20060172281
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Application
    Filed: June 24, 2003
    Publication date: August 3, 2006
    Inventors: Michael Schutz, Roman Meyer, Holger Grallert, Stefan Miller
  • Method for unspecific enrichment of bacterial cells
    Publication number: 20050019827
    Abstract: The present invention relates to a method for unspecific enrichment of bacterial cells by means of cationic or anionic polymers and magnetic carriers.
    Type: Application
    Filed: October 8, 2002
    Publication date: January 27, 2005
    Inventors: Sabine Diller, Renate Grassl, Stefan Miller, Ingrid Robl, Michael Schultz, Thomas Zander
  • Methods for purification of bacterial cells and components
    Publication number: 20040248298
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Application
    Filed: June 15, 2004
    Publication date: December 9, 2004
    Inventors: Michael Schutz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller