Abstract: A planning portal for a farmer to planning and to initiate an agricultural operation of an autonomous agricultural work machine on an agricultural field. The planning portal is configured in such a way that, during planning, only the use is permitted of attachments which may have dimensions such that the attachments are arranged or positioned completely within the detectable surrounding area during the state in which the attachments are coupled to the autonomous agricultural work machine.

Abstract: A route planning system configured to create the route plan for an autonomous agricultural work machine and/or for a network of autonomous agricultural work machines. A given agricultural work machine may be operated in a semi-autonomous operating mode, in which a user is on board or resident in the agricultural work machine, or a fully autonomous operating mode, in which no user is assigned to the agricultural work machine. The generated route plan may be dynamically adapted depending on one or more events, with the dynamically adapted route plan being transmitted to the autonomous agricultural work machine. The user or an operator assigned to the given autonomous agricultural work machine may accept the adapted route plan for the given agricultural work machine.

Abstract: A method for constructing a force sensor group is provided. An expansion body is provided that has integrated force sensor elements. A printed circuit board is provided having electronic components that are configured to receive measurement signals from the force sensor elements. The printed circuit board is electrically connected to the force sensor elements of the expansion body. The electrical connections are protected by applying a potting compound to the electrical connections. Media-tight overmolding of the printed circuit board is performed and at least sections of the expansion body to seal the electronic components and the force sensor elements or to seal and to mechanically protect the electronic components and the force sensor elements.

Abstract: An apparatus includes: a first sensor configured to provide a first input associated with an environment outside a vehicle; a second sensor configured to provide a second input associated with an operation of the vehicle; and a processing unit having a first-stage processing system and a second-stage processing system; the first-stage processing system configured to receive the first input and the second input, process the first input to obtain a first time series of information, and process the second input to obtain a second time series of information; wherein the second-stage processing system comprises a neural network model configured to receive the first time series of information and a second time series of information in parallel; and wherein the neural network is configured to process the first time series and the second time series to determine a probability of a predicted event associated with an operation of the vehicle.

Abstract: An apparatus includes: a first sensor configured to provide a first input; a second sensor configured to provide a second input; and a processing unit configured to receive the first input from the first sensor, and a second input from the second sensor; wherein the processing unit is configured to determine a first probability of a first predicted event, and a second probability of a second predicted event, wherein the first predicted event and the second predicted event are associated with an operation of the vehicle; and wherein the processing unit is configured to calculate a risk score based on the first probability of the first predicted event, and based on the second probability of the second predicted event.

Abstract: The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: An electric machine (120) has a housing (225) and a rotor (205), which is mounted in the housing (225) for rotation about a rotational axis (215). In the housing (225), a recess (230) is provided at one axial end of the rotor (205), in which a closure element (235) is removably attached. A grounding contact (280) is arranged axially between the closure element (235) and the rotor (205).

Abstract: The invention relates to PYY analogues having alanine at position 4, lysine at position 7, QRY as the C-terminal end and a half-life extending group. The analogues of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogues, and to the medical use of the analogues.

Abstract: The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.

Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.

Abstract: An open channel microfluidic device for use in tissue culture is described. The open channel microfluidic device is used as a patterning rail in a cell culture system to create suspended tissues with cells suspended in a hydrogel. The present disclosure also provides methods of preparing a tissue using the open channel microfluidic device described herein.

Abstract: An apparatus includes: a first sensor configured to provide a first input associated with an environment outside a vehicle; a second sensor configured to provide a second input associated with an operation of the vehicle; and a processing unit having a first-stage processing system and a second-stage processing system; the first-stage processing system configured to receive the first input and the second input, process the first input to obtain a first time series of information, and process the second input to obtain a second time series of information; wherein the second-stage processing system comprises a neural network model configured to receive the first time series of information and a second time series of information in parallel; and wherein the neural network is configured to process the first time series and the second time series to determine a probability of a predicted event associated with an operation of the vehicle.

Abstract: The present invention relates to NMU-8 analogues that are neuromedin U receptor 2 (NMUR2) agonists, processes for their preparation, pharmaceutical compositions comprising them and their use in therapy, particularly in the treatment or prevention of disease and/or condition associated with or modulated by NMUR2 activation such as obesity or obesity comorbidities.

Abstract: The invention relates to PYY analogues having alanine at position 4, lysine at position 7, QRY as the C-terminal end and a half-life extending group. The analogues of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogues, and to the medical use of the analogues.

Abstract: The present invention relates to compounds of formula I a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment and/or prevention of conditions having an association with the function of metabotropic glutamate receptor subtype 4 (mGluR4). A, R1, R2, R3, R4, R5 and R6 have meanings given in the description.

Abstract: Described herein is an oral sampling device, as well as methods of making and using the oral sampling device. The oral sampling device is configured to be placed inside of a human mouth to capture an analyte(s) found in bodily fluid, such as saliva, produced within the mouth. An example oral sampling device includes a body, at least a portion of which is sized to fit inside of a mouth of a human, has an outer surface, and a recess(es) defined in the outer surface to capture the analyte(s) therein. In some examples, a material of the body within the recess was subjected to a surface treatment to promote the capture of the analyte(s). In some examples, the oral sampling device includes a flavored substance disposed on at least the portion of the body that is to be received inside of a human mouth.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: A method for producing a boron emitter on at least one silicon wafer, arranged in a tube furnace, including: a step for forming borosilicate glass on the silicon wafer, including in the sequence given: a) evacuating the tube furnace to a specified pressure, b) feeding reagents, having BCU and O2, into the tube furnace and adjusting to a further specified pressure, c) stopping the supply after expiry of a specified period and allowing the reagents supplied to react with each other and a surface of the silicon wafer for a specified period to form a layer of borosilicate glass on the surface of the silicon wafer, and d) evacuating the tube furnace on expiry of the specified period.

Abstract: A connector connecting a line to a printed circuit board. The connector has a section of the line that has a first end, has a connection element that is joined to the end of the section of the line by a first end and is joined to a printed circuit board by a second end, has an insert part that receives the first end of the connection element and the end of the section of the line, the insert part has a recess through which the connection element projects or in which the first end of the connection element and the end of the section of the line are arranged, and has a cured casting compound that fills the recess so as to enclose the connection element or so as to enclose the first end of the connection element and the end joined thereto of the section of the line.