Abstract: A route planning system configured to create the route plan for an autonomous agricultural work machine and/or for a network of autonomous agricultural work machines. A given agricultural work machine may be operated in a semi-autonomous operating mode, in which a user is on board or resident in the agricultural work machine, or a fully autonomous operating mode, in which no user is assigned to the agricultural work machine. The generated route plan may be dynamically adapted depending on one or more events, with the dynamically adapted route plan being transmitted to the autonomous agricultural work machine. The user or an operator assigned to the given autonomous agricultural work machine may accept the adapted route plan for the given agricultural work machine.

Abstract: A planning portal for a farmer to planning and to initiate an agricultural operation of an autonomous agricultural work machine on an agricultural field. The planning portal is configured in such a way that, during planning, only the use is permitted of attachments which may have dimensions such that the attachments are arranged or positioned completely within the detectable surrounding area during the state in which the attachments are coupled to the autonomous agricultural work machine.

Abstract: An apparatus includes: a first sensor configured to provide a first input associated with an environment outside a vehicle; a second sensor configured to provide a second input associated with an operation of the vehicle; and a processing unit having a first-stage processing system and a second-stage processing system; the first-stage processing system configured to receive the first input and the second input, process the first input to obtain a first time series of information, and process the second input to obtain a second time series of information; wherein the second-stage processing system comprises a neural network model configured to receive the first time series of information and a second time series of information in parallel; and wherein the neural network is configured to process the first time series and the second time series to determine a probability of a predicted event associated with an operation of the vehicle.

Abstract: An apparatus includes: a first sensor configured to provide a first input; a second sensor configured to provide a second input; and a processing unit configured to receive the first input from the first sensor, and a second input from the second sensor; wherein the processing unit is configured to determine a first probability of a first predicted event, and a second probability of a second predicted event, wherein the first predicted event and the second predicted event are associated with an operation of the vehicle; and wherein the processing unit is configured to calculate a risk score based on the first probability of the first predicted event, and based on the second probability of the second predicted event.

Abstract: The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: An electric machine (120) has a housing (225) and a rotor (205), which is mounted in the housing (225) for rotation about a rotational axis (215). In the housing (225), a recess (230) is provided at one axial end of the rotor (205), in which a closure element (235) is removably attached. A grounding contact (280) is arranged axially between the closure element (235) and the rotor (205).

Abstract: The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R1, A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: Techniques for efficiently capturing targets, such as biological materials, within the air are described. A lightweight, portable device is configured to capture the targets without desiccation by flowing a mixture of air carrying the targets with liquid droplets through a nonlinear path in a partially enclosed interior of the device. For example, a method includes generating an impinging jet comprising a mixture of air, a target, and droplets. A baffle splits the impinging jet into a recirculation zone and coalesces a mixture of the target and the droplets onto an upper surface of the baffle. At least one channel receives the coalesced mixture and transports the coalesced mixture to a collection reservoir.

Abstract: An open channel microfluidic device for use in tissue culture is described. The open channel microfluidic device is used as a patterning rail in a cell culture system to create suspended tissues with cells suspended in a hydrogel. The present disclosure also provides methods of preparing a tissue using the open channel microfluidic device described herein.

Abstract: An apparatus includes: a first sensor configured to provide a first input associated with an environment outside a vehicle; a second sensor configured to provide a second input associated with an operation of the vehicle; and a processing unit having a first-stage processing system and a second-stage processing system; the first-stage processing system configured to receive the first input and the second input, process the first input to obtain a first time series of information, and process the second input to obtain a second time series of information; wherein the second-stage processing system comprises a neural network model configured to receive the first time series of information and a second time series of information in parallel; and wherein the neural network is configured to process the first time series and the second time series to determine a probability of a predicted event associated with an operation of the vehicle.

Abstract: The invention relates to PYY analogues having alanine at position 4, lysine at position 7, QRY as the C-terminal end and a half-life extending group. The analogues of the invention are soluble around pH 6 and 7. The invention also relates to pharmaceutical compositions comprising such PYY analogues, and to the medical use of the analogues.

Abstract: Described herein is an oral sampling device, as well as methods of making and using the oral sampling device. The oral sampling device is configured to be placed inside of a human mouth to capture an analyte(s) found in bodily fluid, such as saliva, produced within the mouth. An example oral sampling device includes a body, at least a portion of which is sized to fit inside of a mouth of a human, has an outer surface, and a recess(es) defined in the outer surface to capture the analyte(s) therein. In some examples, a material of the body within the recess was subjected to a surface treatment to promote the capture of the analyte(s). In some examples, the oral sampling device includes a flavored substance disposed on at least the portion of the body that is to be received inside of a human mouth.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.

Abstract: Fluidic devices and methods for autonomous droplet generation and methods for droplet manipulation are described. In an embodiment, the fluidic device comprises a substrate defining: an inlet reservoir shaped to receive and to carry a carrier liquid; a converging region in fluidic communication with the inlet reservoir and shaped to receive a liquid sample; a constriction adjacent to and in fluidic communication with the converging region, wherein the constriction defines a pathway configured to allow passage of fluid therethrough; a diverging region in fluidic communication with and downstream of the constriction; and an outlet reservoir in fluidic communication with the diverging region, wherein the fluidic device does not comprise a portion covering the outlet reservoir opposite the substrate.

Abstract: A sample vessel includes a biological sample container and a sample stabilizer container. The biological sample container is configured to receive a biological sample and to store the biological sample. The sample stabilizer container is configured to contain a stabilizer associated with the biological sample. The sample stabilizer container is assembled from a stabilizer vial, an adaptor, and a fluid channel. The stabilizer vial is configured to store an amount of the stabilizer. The adaptor is configured to secure the biological sample container and the stabilizer vial such that the biological sample container and the stabilizer vial form the sample vessel. The fluid channel extends through the adaptor from the stabilizer vial to the biological sample container, the biological sample moving from the biological sample container into the stabilizer vial through the fluid channel.

Abstract: The present invention relates to difluoromethyl-pyridin-2-yl triazoles of general formula (I) which are modulators of GABAA receptors containing the ?5 subunit, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for the manufacture of compounds according to the invention.

Abstract: An apparatus includes: a first sensor configured to provide a first input associated with an environment outside a vehicle; a second sensor configured to provide a second input associated with an operation of the vehicle; and a processing unit having a first-stage processing system and a second-stage processing system; the first-stage processing system configured to receive the first input and the second input, process the first input to obtain a first time series of information, and process the second input to obtain a second time series of information; wherein the second-stage processing system comprises a neural network model configured to receive the first time series of information and a second time series of information in parallel; and wherein the neural network is configured to process the first time series and the second time series to determine a probability of a predicted event associated with an operation of the vehicle.

Abstract: An apparatus includes: a first sensor configured to provide a first input; a second sensor configured to provide a second input; and a processing unit configured to receive the first input from the first sensor, and a second input from the second sensor; wherein the processing unit is configured to determine a first probability of a first predicted event, and a second probability of a second predicted event, wherein the first predicted event and the second predicted event are associated with an operation of the vehicle; and wherein the processing unit is configured to calculate a risk score based on the first probability of the first predicted event, and based on the second probability of the second predicted event.

Abstract: The invention relates to a mobile crane with a two-part jib and to a method for aligning the boom system of such a mobile crane. The invention relates to a mobile crane with a multi-part flight boom, wherein a first jib part is hinged to the main boom in a rockable manner, and at least one second jib part is secured to the first jib part in an articulated manner. A bracing which is guided from the upper chassis to the jib is provided for aligning the jib, said bracing running over at least one intermediate bracing support mounted on the first jib part to the at least one second jib part.

Abstract: A milling device for machining a slot into an inner surface of a casing for a gas turbine engine. The milling device includes a frame assembly including multiple structural guides configured to engage structural features on the inner surface of the casing to maintain an axial position of the milling device relative to a longitudinal axis of the casing. The milling device also includes a milling cutter coupled to the frame assembly. The milling device is configured to be displaced in a circumferential direction relative to the longitudinal axis to machine the slot, via the milling cutter, along the inner surface of the casing in the circumferential direction.