Abstract: An instrument holder is described for mounting a medical instrument on a joint arm, comprising a body, a holder for holding the medical instrument on the body, and a coupling element for attaching the body to the joint arm. The holder comprises a threaded shank provided with an external thread, a receiving disc and a locking element provided with an internal thread. The receiving disc has a through-hole, by which the receiving disc can be put on the threaded shank and is rotatable about the threaded shank.

Abstract: The present invention relates to an encapsulated semiconductor device (20) provided on a flexible substrate (1), a method of providing an at least partially encapsulated semiconductor device (20) on a flexible substrate (1) and a software product for providing an at least partially encapsulated semiconductor device (20) on a flexible substrate (1). In a preferred embodiment, an encapsulation method is presented in which the organic layer (3) of an inorganic/organic/inorganic multilayer barrier (5) on a plastic foil (1) as a substrate is removed at the edges of an OLED (13). The edges are subsequently sealed with a standard TFE process to encapsulate the OLED (13). This enables cuttable OLEDs (20) that are cut out of a larger plastic substrate (1) and gives a method to reduce side leakage in OLEDs (20) that have been manufactured in a roll-to-toll process.

Abstract: The invention relates to new pyridinyl derivatives of the formula wherein R1 and A are as defined in the description and claims, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

Abstract: The invention relates to OLEDs (1) having a substrate (2), a first electrode layer (3), a layer of organic electroluminescence material (4), a second electrode layer (5), a cover layer (6), moisture-absorbing means (9) and a separating foil (10) of resilient material. According to the invention, said foil (10) is positioned between the second electrode layer (5) and the moisture-absorbing means (9). This feature results in a longer mean life-time of the OLED. Advantageously spacer structures (12) (preferably formed as dots) are applied on the separating foil (10) between the foil (10) and the cover (6). This prevents discoloring effects around the rim of the OLED material.

Abstract: The invention relates to a substrate (2) for manufacturing an organic conversion device for converting electrical energy into light energy or light energy into electrical energy, wherein the substrate comprises a) an encapsulation layer (3) on the substrate, wherein the encapsulation layer includes a first inorganic layer (7), a second inorganic layer (9) and an intermediate organic layer (8), and b) a getter reservoir (6) in contact with the organic layer of the encapsulation layer. Water molecules will therefore not only be transported along the intermediate organic layer, but will also be gathered, especially absorbed, by the getter reservoir, if the encapsulation is damaged. This can slow down a transport of water molecules along a leakage path towards an organic conversion layer of the organic conversion device and hence slow down a possible degradation of the performance of the organic conversion device, if the encapsulation layer is damaged.

Abstract: A method for producing a flat steel product with high reflectivity, in which at least one surface has an arithmetic mean roughness Ra of less than 0.03 ?m includes providing a flat steel product, at least one surface of which has an arithmetic mean roughness Ra of less than 2.5 ?m. The flat steel product is cold rolled in a plurality of rolling passes. Also a flat steel product with high reflectivity in the finished re-rolled state on at least one of its surface has a low arithmetic mean roughness, a high gloss, and a high directed reflection. A solar concentrator is produced from such a flat steel product.

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: The present invention relates to a current-light conversion device (1), such as an OLED or an OPVD, wherein the current-light conversion device comprises a substrate (10), a current-light conversion arrangement (11) comprising a current-light conversion material (111) provided between a first and a second electrode layer (110, 112), and a barrier layer (12) comprising a transparent organic layer (121) provided between a first and a second transparent inorganic barrier layer (120, 122). A getter material is provided in the transparent organic layer (121) in a pattern of getter dots (1210). Since the getter material is provided in a pattern of getter dots (1210), the light scattering effect resulting from dispersed getter particles can be avoided, resulting in improved transparency characteristics of the barrier layer (12) while still providing the desired getter functionality.

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.

Abstract: A system for project planning for an engine for determining an operating behavior of the engine to be expected under defined operating conditions of the engine includes: a plurality of sensors configured to measure respective ones of the defined operating conditions of the engine; and a knocking intensity prediction tool configured to determine the knocking intensity of the engine to be expected under the defined operating conditions of the engine.

Abstract: The present invention relates to compounds of general formula I, wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

Abstract: The present invention relates to compounds of general formula I, wherein the groups R, R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

Abstract: The invention relates to OLEDs (1) having a substrate (2), a first electrode layer (3), a layer of organic electroluminescence material (4), a second electrode layer (5), a cover layer (6), moisture-absorbing means (9) and a separating foil (10) of resilient material. According to the invention, said foil (10) is positioned between the second electrode layer (5) and the moisture-absorbing means (9). This feature results in a longer mean life-time of the OLED. Advantageously spacer structures (12) (preferably formed as dots) are applied on the separating foil (10) between the foil (10) and the cover (6). This prevents discoloring effects around the rim of the OLED material.

Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: The present invention relates to an encapsulated semiconductor device (20) provided on a flexible substrate (1), a method of providing an at least partially encapsulated semiconductor device (20) on a flexible substrate (1) and a software product for providing an at least partially encapsulated semiconductor device (20) on a flexible substrate (1). In a preferred embodiment, an encapsulation method is presented in which the organic layer (3) of an inorganic/organic/inorganic multilayer barrier (5) on a plastic foil (1) as a substrate is removed at the edges of an OLED (13). The edges are subsequently sealed with a standard TFE process to encapsulate the OLED (13). This enables cuttable OLEDs (20) that are cut out of a larger plastic substrate (1) and gives a method to reduce side leakage in OLEDs (20) that have been manufactured in a roll-to-toll process.

Abstract: A method for determining a gas consumption of a gas-powered gas engine or a gas-powered dual-fuel engine. The engine is operated under actual operating conditions, and the actual gas consumption of the engine is acquired under the actual operating conditions. A target gas consumption of the engine to be anticipated under target operating conditions is calculated depending on the actual gas consumption and depending on discrepancies between the actual operating conditions and the target operating conditions.

Abstract: This invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.