Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.

Abstract: Substituted dihydropyrimidinones of formula 1 which are neutrophil elastase inhibitors and useful as medicaments for the treatment of, inter alia, COPD.

Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.

Abstract: A patient-supporting device is disclosed. The patient-supporting device includes a fastening assembly that fastens the patient-supporting device to a structural member, a support member configured to receive a body part of a patient, and a height adjustment assembly that adjusts a distance between the fastening assembly and the support member. The height adjustment assembly includes a locking assembly and an elongated member. The support member is attached to a first end portion of the elongated member. The locking assembly is stationary relative to the fastening assembly. The elongated member is guided in an aperture of the locking assembly in a longitudinal direction of the elongated member. A plurality of first snap-in recesses is disposed on a first side portion of the elongated member. The locking assembly includes a first locking member.

Abstract: An organic electroluminescence device (OLED) has a substrate, a first electrode layer, a layer of organic electroluminescence material, a second electrode layer, a cover layer, a moisture-absorber and a separating foil of resilient material. The separating foil is positioned between the second electrode layer and the moisture-absorber. Spacer structures such as dots are applied on the separating foil between the foil and the cover.

Abstract: A rotary angle sensor used to determine a relative angular position as compared to a reference position, comprising a housing (1), at least one rotor (3, 4) that is rotatably mounted inside said housing (1), one circuit board (2) containing electrical and/or electronic components as well as one or multiple stators corresponding to the number of used rotors (3, 4). The rotary angle sensor is supposed to be improved in such a manner that a particularly precise alignment of the first rotor (3) in relation to the stator is ensured and that it is inexpensive to manufacture. This is achieved by a first rotor (3) that is interlocked with the housing (1) without any play while a pre-loaded spring washer (14) is positioned on the latching arms (11).

Abstract: This invention relates to substituted 4-pyridones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other auto-immune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11?-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

Abstract: A rotary angle sensor used to determine a relative angular position as compared to a reference position, comprising a housing (1), at least one rotor (3, 4) that is rotatably mounted inside said housing (1), one circuit board (2) containing electrical and/or electronic components as well as one or multiple stators corresponding to the number of used rotors (3, 4). The rotary angle sensor is supposed to be improved in such a manner that allows for an especially precise alignment of a circuit board inside a housing and an easy installation of said board. This is achieved by the circumstance that bearing surfaces (9) for the circuit board (2) are provided in the direct radial vicinity of the stator inside the housing (1) and that clamping structures (11) are radially aligned with the stator in order to position the circuit board (2).

Abstract: The invention relates to an OLED(1) comprising an etch stop layer (3) between a first electrode (2) and anorganic layer stack (4) and an electrically conductive element (13) arranged in an etched region (6) within a second electrode (5) and the organic layer stack such that the electrically conductive element is electrically connected with the first electrode. The etch stop layer is a hole-injection layer comprising a metal oxide with semi conducting properties. In particular, the OLED may comprise several electrically conductive elements in several etched regions, wherein the electrically conductive elements can be electrically connected with different parts of the first electrode and with each other via an electrical connector (14) for shunting the different parts of the first electrode, which can lead to a more homogenous light emission. The electrical conductive elements may also be used to provide a color tunability.

Abstract: This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.

Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD.

Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: This invention relates to substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.

Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and useful as medicaments for the treatment of, inter alia, COPD.

Abstract: Substituted dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase activity and which are useful as medicaments for the treatment of, inter alia, COPD.

Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 and their use as inhibitors of neutrophil elastase activity.

Abstract: Substituted bicyclic dihydropyrimidinones of formula 1 which are inhibitors of neutrophil elastase and useful as medicaments for the treatment of, inter alia, COPD.