Patents by Inventor STEFAN PRONIUK

STEFAN PRONIUK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Onapristone extended-release compositions and methods
    Patent number: 11672762
    Abstract: Onapristone extended-release formulations and methods of administering onapristone extended-release formulations are provided. Onapristone extended-release formulations provide sufficient therapeutic activity as compared to immediate-release formulations with reduced potential for adverse side effects.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 13, 2023
    Assignee: CONTEXT BIOPHARMA, INC.
    Inventors: Alexander Zukiwski, Stefan Proniuk
  • ONAPRISTONE EXTENDED-RELEASE COMPOSITIONS AND METHODS
    Publication number: 20230157960
    Abstract: Onapristone extended-release formulations and methods of administering onapristone extended-release formulations are provided. Onapristone extended-release formulations provide sufficient therapeutic activity as compared to immediate-release formulations with reduced potential for adverse side effects.
    Type: Application
    Filed: January 9, 2023
    Publication date: May 25, 2023
    Inventors: Alexander Zukiwski, Stefan Proniuk
  • Methods for onapristone synthesis dehydration and deprotection
    Patent number: 11613555
    Abstract: Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: March 28, 2023
    Assignee: CONTEXT BIOPHARMA, INC.
    Inventors: Ulf Tilstam, Stefan Proniuk, Ferry Brands
  • LIPID CRYSTALLINE COMPOSITIONS WITH ENHANCED STABILITY FOR TOPICAL DELIVERY OF ACTIVE AGENT COMBINATIONS
    Publication number: 20230000795
    Abstract: Multiple active component therapeutic formulations are described comprising at least two active agents selected from the group consisting of an isovanillin component, a harmine component, and a curcumin component, stabilized in a self-supporting lipid crystalline formulation for topical application. The formulation maintains the active agents in a stable form during storage and will melt at body temperature when applied to the skin, wherein the lipid crystals melt into a liquid crystalline structure thereby releasing the active agents to the applied area of the skin or tissue to render their therapeutic effect.
    Type: Application
    Filed: June 10, 2022
    Publication date: January 5, 2023
    Applicant: Ankh Life Sciences Limited
    Inventors: Gene H. Zaid, Åke Richard Lindal, Anette Susanne Nilsson, Cameron E. West, Stefan Proniuk, Robert Preston Moore
  • ONAPRISTONE EXTENDED-RELEASE COMPOSITIONS AND METHODS
    Publication number: 20210220279
    Abstract: Onapristone extended-release formulations and methods of administering onapristone extended-release formulations are provided. Onapristone extended-release formulations provide sufficient therapeutic activity as compared to immediate-release formulations with reduced potential for adverse side effects.
    Type: Application
    Filed: September 28, 2020
    Publication date: July 22, 2021
    Inventors: Alexander Zukiwski, Stefan Proniuk
  • METHODS FOR ONAPRISTONE SYNTHESIS DEHYDRATION AND DEPROTECTION
    Publication number: 20210221838
    Abstract: Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
    Type: Application
    Filed: September 28, 2020
    Publication date: July 22, 2021
    Inventors: Ulf Tilstam, Stefan Proniuk, Ferry Brands
  • AMORPHOUS ONAPRISTONE COMPOSITIONS AND METHODS OF MAKING THE SAME
    Publication number: 20200376004
    Abstract: Amorphous forms of onapristone and methods of making such amorphous forms are provided. Amorphous forms can be characterized by their X-ray powder diffraction patterns and other properties.
    Type: Application
    Filed: December 19, 2019
    Publication date: December 3, 2020
    Inventors: Harry G. Brittain, Stefan Proniuk
  • Onapristone extended-release compositions and methods
    Patent number: 10786461
    Abstract: Onapristone extended-release formulations and methods of administering onapristone extended-release formulations are provided. Onapristone extended-release formulations provide sufficient therapeutic activity as compared to immediate-release formulations with reduced potential for adverse side effects.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: September 29, 2020
    Assignee: CONTEXT BIOPHARMA INC.
    Inventors: Alexander Zukiwski, Stefan Proniuk
  • Amorphous onapristone compositions and methods of making the same
    Patent number: 10548905
    Abstract: Amorphous forms of onapristone and methods of making such amorphous forms are provided. Amorphous forms can be characterized by their X-ray powder diffraction patterns and other properties.
    Type: Grant
    Filed: December 13, 2016
    Date of Patent: February 4, 2020
    Assignee: CONTEXT BIOPHARMA INC.
    Inventors: Harry G. Brittain, Stefan Proniuk
  • Methods of making onapristone intermediates
    Patent number: 10308676
    Abstract: Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: June 4, 2019
    Assignee: CONTEXT BIOPHARMA INC.
    Inventors: Ulf Tilstam, Stefan Proniuk, Holger Bindernagel, Silvia Werner, Holger Rauter
  • Drug delivery system to increase bioavailability
    Patent number: 10039833
    Abstract: Drug delivery systems and compositions, comprising a glidant, that increase the bioavailability of biopharmaceutic class II, III, or IV active agents, and methods of making the same, are provided.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: August 7, 2018
    Assignee: OHIO STATE INNOVATION FOUNDATION
    Inventors: Anh Thu Thi Pham, Akaash Kumari Singh, Stefan Proniuk
  • METHODS FOR ONAPRISTONE SYNTHESIS DEHYDRATION AND DEPROTECTION
    Publication number: 20180148471
    Abstract: Methods and systems for making onapristone (ONA) using acidic hydrolysis and dehydration with sulfuric acid in an alcoholic solution are provided.
    Type: Application
    Filed: November 29, 2017
    Publication date: May 31, 2018
    Inventors: Ulf Tilstam, Stefan Proniuk, Ferry Brands
  • Compositions and methods for reducing prion levels
    Patent number: 9974771
    Abstract: Compositions and methods for reducing the level of prions in a prion-infected cells or host by exposing prion infected cells, tissues and organs to AR-12 and the AR-12 analog AR-14 to reduce the prion level by at least about 90%.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: May 22, 2018
    Assignees: OHIO STATE INNOVATION FOUNDATION, UTI LIMITED PARTNERSHIP
    Inventors: Hermann M. Schaetzl, Basant Abdulrahman, Sabine Gilch, Alexander Zukiwski, Stefan Proniuk
  • DRUG DELIVERY SYSTEM TO INCREASE BIOAVAILABILITY
    Publication number: 20180000945
    Abstract: A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
    Type: Application
    Filed: January 26, 2017
    Publication date: January 4, 2018
    Inventors: Anh Thu Thi Pham, Akaash Kumari Singh, Stefan Proniuk
  • COMPOSITIONS AND METHODS FOR REDUCING PRION LEVELS
    Publication number: 20170326108
    Abstract: Compositions and methods for reducing the level of prions in a prion-infected cells or host by exposing prion infected cells, tissues and organs to AR-12 and the AR-12 analog AR-14 to reduce the prion level by at least about 90%.
    Type: Application
    Filed: February 28, 2017
    Publication date: November 16, 2017
    Inventors: Hermann M. Schaetzl, Basant Abdulrahman, Sabine Gilch, Alexander Zukiwski, Stefan Proniuk
  • ONAPRISTONE METABOLITE COMPOSITIONS AND METHODS
    Publication number: 20170266204
    Abstract: Methods and pharmaceutical compositions for inhibiting the activity of the progesterone receptor with methyl onapristone. Aspects include methods of administering methyl onapristone to a patient in an amount sufficient to achieve a blood or tissue concentration of at least about 100 nM.
    Type: Application
    Filed: March 20, 2017
    Publication date: September 21, 2017
    Inventors: Stefan Proniuk, Souzan Yanni
  • Methods and compositions for enhanced transungual delivery of AR-12
    Patent number: 9744156
    Abstract: Methods and compositions for enhancing transungual delivery of AR-12 comprising administering AR-12 and permeation enhancers are provided.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: August 29, 2017
    Assignee: ARNO THERAPEUTICS, INC.
    Inventors: Sathyanarayana Narasimha Murthy, Stefan Proniuk
  • AMORPHOUS ONAPRISTONE COMPOSITIONS AND METHODS OF MAKING THE SAME
    Publication number: 20170182065
    Abstract: Amorphous forms of onapristone and methods of making such amorphous forms are provided. Amorphous forms can be characterized by their X-ray powder diffraction patterns and other properties.
    Type: Application
    Filed: December 13, 2016
    Publication date: June 29, 2017
    Inventors: Harry G. Brittain, Stefan Proniuk
  • METHODS OF MAKING ONAPRISTONE INTERMEDIATES
    Publication number: 20170088579
    Abstract: Methods and systems for making intermediates in the synthesis of onapristone are provided. Aspects include the photoconversion of onapristone synthesis intermediates using a narrow band frequency light source.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 30, 2017
    Inventors: Ulf Tilstam, Stefan Proniuk, Holger Bindernagel, Silvia Werner, Holger Rauter
  • Drug delivery system to increase bioavailability
    Patent number: 9579387
    Abstract: A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: February 28, 2017
    Assignee: ARNO THERAPEUTICS, INC.
    Inventors: Anh Thu Thi Pham, Akaash Kumari Singh, Stefan Proniuk