Patents by Inventor Stefan Sjolander

Stefan Sjolander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5955729
    Abstract: The invention provides surface plasmon resonance-mass spectroscopy for the rapid, sensitive and accurate investigation of molecular interactions coupled with the identification and quantification of the same. Methods of the invention include capturing an analyte present within a sample by an interactive surface layer on a real-time interaction analysis sensor, analyzing the analyte by surface plasmon resonance while the analyte is captured by the interactive surface layer, and identifying the captured analyte by desorbing/ionizing the analyte from the interactive surface layer while under vacuum within a mass spectrometer. Devices of the invention include a transparent material, a conductive material capable of supporting surface plasmon resonance affixed to the transparent material, an interactive surface affixed to the conductive material, and a means for exposing the interactive surface to the interior of a mass spectrometer without breaking the vacuum therein.
    Type: Grant
    Filed: September 6, 1996
    Date of Patent: September 21, 1999
    Assignee: Biacore AB
    Inventors: Randall W. Nelson, Jennifer R. Krone, Russell Granzow, Osten Jansson, Stefan Sjolander
  • Patent number: 5593130
    Abstract: A valve of the membrane valve type comprises a valve body with two fluid flow channels (5, 5') separated by a land portion which forms a valve seat (6) having a sealing surface for co-operation with a flexible membrane (7) mounted over a duct (8) which opens in front of the valve seat and is arranged for fluid pressure actuation of the membrane between a closing position, where the membrane (7) sealingly contacts the valve seat (6), and an opening position where there is a flow channel communicating space ( 11) between the valve seat (6) and the membrane (7).
    Type: Grant
    Filed: March 6, 1996
    Date of Patent: January 14, 1997
    Assignee: Pharmacia Biosensor AB
    Inventors: Thord Hansson, Stefan Sjolander
  • Patent number: 5313264
    Abstract: An optical biosensor system using internal reflection versus angle of incidence determination for the detection of biomolecules, the system comprising a sensor unit (10) with at least two sensing surfaces (39A-D), a source of light (1), and lens means (2) for forming a convergent beam of light which is focused in wedge-shape fashion to form a streak of light (5) extending transversely over all the sensing surfaces; a photodetector device (7) in the form of a two-dimensional matrix of individual photodetector; optical imaging instrumentation in the form of an anamorphic lens system (6) for the purpose of imaging rays of reflected light from the sensing surfaces on each its own column of photodetectors, so that for each sensing surface there is a corresponding set of columns of photodetectors; and an evaluation unit (8) for determining the minimum reflectance or the resonance angle at each of the sensing surfaces.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: May 17, 1994
    Assignee: Pharmacia Biosensor AB
    Inventors: Bengt Ivarsson, Jonsson Ulf, Stefan Sjolander, Ralph St.ang.hlberg, Hakan Sjodin