Abstract: The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.

Abstract: The present invention discloses a conjugate comprising an antigen (for example a saccharide antigen) covalently linked to a Pseudomonas aeruginosa PcrV carrier protein comprising an amino acid sequence which is at least 80% identical to the sequence of SEQ ID NO:1-4, wherein the antigen is linked (either directly or through a linker) to an amino acid residue of the P. aeruginosa PcrV carrier protein. The invention also discloses Pseudomonas aeruginosa PcrV proteins that contain glycosylation site consensus sequences.

Abstract: In a method, computer readable medium, or system for making a payment transaction between a payor having an associated payor computer with a ledger storage for the payor and a payee having an associated payee computer with a ledger storage for the payee in a consensus payment network having a plurality of nodes each comprising a respective computer with ledger storage and relying on consensus determinations, an initiator is provided for making the payment transaction between the payor and the payee, the initiator being either the payor, the payee, or an intermediary having an associated intermediary computer. The respective initiator computer creates a temporary payment transaction consensus subnetwork comprising a set of validation nodes acceptable to both the payor and the payee, the set of validation nodes comprising fewer than all of said plurality of nodes in the payment network.

Abstract: Audio splicing is rendered more effective by the use of one or more truncation unit packets inserted into the audio data stream so as to indicate to an audio decoder, for a predetermined access unit, an end portion of an audio frame with which the predetermined access unit is associated, as to be discarded in playout.

Abstract: A partial beam splitter includes a substrate including a substrate material; and a coating arranged on at least one main surface of the substrate. Along a first direction which is parallel to a normal vector of the main surface, the substrate and all coatings having a total thickness. For a specific light beam having a specific wavelength within a range of 450 nm and 650 nm which is incident on the partial beam splitter along a second direction with an angle of 32° enclosed between a vector pointing in the first direction and a vector pointing in the second direction, the specific light beam after transmitting through the partial beam splitter has a phase having a phase difference of an absolute value of smaller than or equal to 30° compared to the case in which, under otherwise identical conditions, the partial beam splitter is replaced by a similar reference substrate.

Abstract: The disclosure provides synthetic (e.g. recombinant) pneumococcal saccharide comprising one or more repeat unit(s) ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?. Also provided are conjugates comprising a ?4)-?-D-Glcp-(1?3)-[[?-L-Rhap-(1?2)]-[Gro-(2?P?3)]-?-D-Galp-(1?4)]-?-L-Rhap-(1?, immunogenic compositions, vaccines and their use in preventing or treating infection by Streptococcus pneumoniae.

Abstract: A waveguide for guiding an image pixel light includes: a solid body including an optical material which is transparent for at least a light with a wavelength of 460 nm; an in-coupling surface located on the solid body; and an out-coupling surface located on the solid body, wherein the optical material has an absorption coefficient ?460 nm for light having a wavelength of 460 nm, a thermal conductivity k, a coefficient of thermal expansion ?20° C. at a temperature of 20° C., a refractive index nF related to the hydrogen F-line, and a derivative dnF/dT20° C. which are related in such a way that a thermally induced change of an optical path length within the waveguide due to an absorption of at least one of heat and an optical radiation is quantitatively described by a merit function.

Abstract: A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

Abstract: A method for predicting the behavior of at least one road user in a traffic situation. The method includes: obtaining a graph representation of the traffic situation, wherein nodes represent road users, edges represent interactions between the road users and define an adjacency between road users, each node is associated with a state, and each edge is associated with edge attributes; computing an evolution of the states of the nodes based at least in part on a self-evolution of the state of each considered node that is dependent on this state and mediated by a self-evolution operator; and an interaction of each considered node with other nodes that is dependent on the states of these other nodes and mediated by an interaction operator; and computing a sought property that characterizes the behavior of the at least one road user.

Abstract: Systems and techniques are provided for a resource transfer system. An instruction to transfer a first quantity of a resource from a first resource pool to a second resource pool may be received. A hold may be placed on a second quantity of the resource in the first resource pool. The held second quantity of the first resource may not be transferred from the first resource pool until the hold is released. Responsive to receiving a message that fulfills a condition on the hold and an instruction to execute the transfer, the hold may be released. A register that is in the first resource pool and is associated with the resource may decremented by the first quantity, and a register that is in the second resource pool and is associated with the resource may be incremented by the first quantity.

Abstract: A container seal includes a locking bolt, which has on one end portion or central portion thereof a push-in/latch compartment which is open in the transverse direction relative to the lock axis and is formed or provided with an undercut acting in the direction of the latch compartment opening; a clip or tab, wherein the clip or tab is arranged on the other end portion of the locking bolt; and a bolt or bar which is arranged on the free end/end portion of the clip or tab and has on the free end/end portion thereof a latch device which is coupled to the bolt via a predetermined breaking point.

Abstract: In a method, computer readable medium, or system for making a payment transaction between a payor having an associated payor computer with a ledger storage for the payor and a payee having an associated payee computer with a ledger storage for the payee in a consensus payment network having a plurality of nodes each comprising a respective computer with ledger storage and relying on consensus determinations, an initiator is provided for making the payment transaction between the payor and the payee, the initiator being either the payor, the payee, or an intermediary having an associated intermediary computer. The respective initiator computer creates a temporary payment transaction consensus subnetwork comprising a set of validation nodes acceptable to both the payor and the payee, the set of validation nodes comprising fewer than all of said plurality of nodes in the payment network.

Abstract: A container seal includes a locking bolt, which has on one end portion or central portion thereof a push-in/latch compartment which is open in the transverse direction relative to the lock axis and is formed or provided with an undercut acting in the direction of the latch compartment opening; a clip or tab, wherein the clip or tab is arranged on the other end portion of the locking bolt; and a bolt or bar which is arranged on the free end/end portion of the clip or tab and has on the free end/end portion thereof a latch device which is coupled to the bolt via a predetermined breaking point.

Abstract: An apparatus (100) and a method for a point of care drug product delivery are provided. A point of care drug product delivery apparatus includes a central interface member (110) that serves as an interface between a saline source, a drug product source, and an infusion line. The central interface member facilitates priming the infusion line with saline from the saline source, infusing drug product to a patient from the drug product source, and flushing the infusion line with saline from the saline source. According to aspects of the current subject matter, the central interface member provides and/or forms fluidic connections and/or passageways between various ones of the saline source, the drug product source, and the infusion line.

Abstract: Systems and techniques are provided for electronic payment network security. Payment data including an origin and a destination for a payment in an electronic payment network may be received. A route of the payment in the electronic payment network may be estimated based on the origin and the destination. The estimated route of the payment in the electronic payment network may be input to a neural network. Fraud probabilities may be determined using the neural network. A fraud probability may include a value indicating a probability of fraud in the payment in the electronic payment network.

Abstract: A sterile container and a closure mechanism for the sterile container. The sterile container includes a container pan and a container lid. The container lid is lockable to the container pan by the closure mechanism. The closure mechanism has a bar element for undercut engagement with an engagement element arranged on the container pan or on the container lid and which forms an undercut. The bar element is positionable in a closed position, in which the bar element is operatively engaged with the engagement element via the undercut, and in a release position, in which the bar element and the engagement element are disengaged. The closure mechanism includes a locking element that is operatively connectable to the bar element and which is integrated into the closure mechanism in such a way that the locking element blocks the closure mechanism when the closed position is reached.

Abstract: Systems and techniques are provided for a resource transfer system. An instruction to transfer a first quantity of a resource from a first resource pool to a second resource pool may be received. A hold may be placed on a second quantity of the resource in the first resource pool. The held second quantity of the first resource may not be transferred from the first resource pool until the hold is released. Responsive to receiving a message that fulfills a condition on the hold and an instruction to execute the transfer, the hold may be released. A register that is in the first resource pool and is associated with the resource may decremented by the first quantity, and a register that is in the second resource pool and is associated with the resource may be incremented by the first quantity.

Abstract: The invention relates to a method of an optimal arrangement in time of a laser emitter and a detector for a remote sensing application, comprising: —setting a target time unit integration time tp; —translating said time unit integration time into a reduced time ?p and its corresponding power increase factor ??1; —activating both the laser emitter, with a power output corrected by ??1, and the detector for a duration of ?p; —deactivating the emitter and detector after duration ?p; —keep emitter and detector off for the subsequent duration toff=tp??p.The invention further relates to a device implementing said method.