Abstract: An anti-loosening device for a fastening unit of a motor-vehicle wheel is configured to be coupled with a wheel hub. The anti-loosening device is configured to be arranged within the wheel hub along an axial direction, so that a main axis of the anti-loosening device coincides with the wheel axis. The anti-loosening device includes a gear arranged to cooperate with inner teeth of the wheel hub, an elastic element extending axially with respect to the gear, and a coupling element obtained on a sector of said gear, arranged to receive a corresponding fastening. During assembly of the wheel—hub assembly, the anti-loosening device is arranged to create a compressed configuration, wherein the gear is decoupled with respect to the inner teeth, and is arranged within a cavity portion obtained on the inner surface of the wheel hub, so as to allow rotation of the anti-loosening device around the main axis.

Abstract: Provided herein are various crystalline forms of 4-amino-N-[4-(methoxymethyl)phenyl]-7-(1-methylcyclopropyl)-6-(3-morpholinoprop-1-yn-1-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide, methods of producing same, and methods of using same to for RET inhibition.

Abstract: A tool for mounting a motor-vehicle wheel on a wheel hub includes a tubular body having a coupling portion arranged for coupling to the wheel hub, and a carrier portion for supporting the motor-vehicle wheel during a centering phase of the wheel on the hub. The tool has an inner tubular member and an outer tubular member rigidly connected to each other so as to be coaxial. At the coupling portion, the inner and outer tubular members are spaced apart so as to define a space arranged to receive an end portion of the wheel hub, in such a way that, in an operating condition, the end portion of the hub is interposed between the inner tubular member and the outer tubular member.

Abstract: The invention describes a cosmetic article, in particular for make-up, in stick form comprising a transparent external product and a liquid internal product in which solid decorative elements are dispersed. The cosmetic article features an attractive, original appearance, which can be appreciated from both an aesthetic and a functional point of view upon application thereof to skin.

Abstract: The present invention relates to a new process for the preparation of the crystalline polymorph of sodium neridronate in form hemihydrate F, comprising the following steps: a) reacting the 6-aminohexanoic acid with a mixture of phosphorous acid and methanesulfonic acid at a temperature in the range from 60 to 80° C., under stirring, until a clear solution is obtained; b) adding phosphorus trichloride to said solution of step (a) under stirring at a temperature in the range of 60 to 80° C.; c) diluting with water the reaction mixture obtained from the previous step (b) and heating said water diluted mixture at a temperature in the range from 80 to 120° C.; d) cooling the heated mixture obtained in step (c) up to room temperature, diluting it with water, then slowly adding an aqueous sodium hydroxide solution up to a pH in the range from 4.2 to 4.6, to obtain a neutralized solution; e) bringing the neutralized solution of step (d) up to a temperature of about 70° C.

Abstract: A suspension device of a motor-vehicle wheel includes a support member of the motor-vehicle wheel connectable to the motor-vehicle structure by means of one or more suspension members, a brake disc connected in rotation with the motor-vehicle wheel, a brake caliper associated with the brake disc and a brake disc cover. The brake caliper is formed in a single piece with the support member of the motor-vehicle wheel by means of additive manufacturing technology.

Abstract: A vehicle braking system includes a controller that receives signals from sensors associated with vehicle disc brakes, which allow detection of a parameter indicative of a degree of noise generated from each disc brake. When noise generation is detected, the controller activates a noise attenuation function of a first type if the vehicle is braking, and of a second type if the vehicle is not braking. The first type involves reducing actuating pressure of a fluid actuator associated with the disc brake for which noise generation is detected. The second type involves temporarily activating, while the vehicle is running and not braking, the fluid actuator associated with the disc brake which is generating noise. The controller also receives signals indicative of vehicle operating parameters which allow conditions to be defined in which priority is given to vehicle safety, and in which the noise attenuation function is excluded.

Abstract: The present invention relates to a new process for the preparation of the crystalline polymorph of sodium neridronate in form hemihydrate F, comprising the following steps: a) reacting the 6-aminohexanoic acid with a mixture of phosphorous acid and methanesulfonic acid at a temperature in the range from 60 to 80° C., under stirring, until a clear solution is obtained; b) adding rl phosphorus trichloride to said solution of step (a) under stirring at a temperature in the range of 60 to 80° C.; c) diluting with water the reaction mixture obtained from the previous step (b) and heating said water diluted mixture at a temperature in the range from 80 to 120° C.; d) cooling the heated mixture obtained in step (c) up to room temperature, diluting it with water, then slowly adding an aqueous sodium hydroxide solution up to a pH in the range from 4.2 to 4.6, to obtain a neutralized solution; e) bringing the neutralized solution of step (d) up to a temperature of about 70° C.

Abstract: A vehicle braking system includes an assistance device having a vacuum pump driven by an engine for communicating vacuum to a chamber of the assistance device. A control valve is interposed along a fluid line between the pump and the chamber. The control valve is in its first operative condition, where the inlet side of the vacuum pump communicates with the chamber, when pressure within the chamber is above a predetermined value; and is in its second operative condition, where the inlet side of the vacuum pump communicates with the atmosphere, when pressure within the chamber is below a predetermined value. In this second condition the pump intakes air from and feeds air into the atmosphere, thereby reducing the energy consumption by the engine required for driving the pump during stages where, within the chamber, there is a vacuum sufficient for the regular operation of the braking system.

Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent.

Abstract: Described herein are polymorphic forms of 1,6-dibromo-1,6-dideoxy-dulcitol (dibromo dulcitol or DBD), which is a known antitumor agent. Also described are methods of making these new crystalline polymorphic forms as well as methods of using these polymorphic forms to treat cancer.

Abstract: An anti-loosening device for a fastening unit of a motor-vehicle wheel is configured to be coupled with a wheel hub. The anti-loosening device is configured to be arranged within the wheel hub along an axial direction, so that a main axis of the anti-loosening device coincides with the wheel axis. The anti-loosening device includes a gear arranged to cooperate with inner teeth of the wheel hub, an elastic element extending axially with respect to the gear, and a coupling element obtained on a sector of said gear, arranged to receive a corresponding fastening. During assembly of the wheel—hub assembly, the anti-loosening device is arranged to create a compressed configuration, wherein the gear is decoupled with respect to the inner teeth, and is arranged within a cavity portion obtained on the inner surface of the wheel hub, so as to allow rotation of the anti-loosening device around the main axis.

Abstract: A tool for mounting a motor-vehicle wheel on a wheel hub includes a tubular body having a coupling portion arranged for coupling to the wheel hub, and a carrier portion for supporting the motor-vehicle wheel during a centering phase of the wheel on the hub. The tool has an inner tubular member and an outer tubular member rigidly connected to each other so as to be coaxial. At the coupling portion, the inner and outer tubular members are spaced apart so as to define a space arranged to receive an end portion of the wheel hub, in such a way that, in an operating condition, the end portion of the hub is interposed between the inner tubular member and the outer tubular member.

Abstract: Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I:

Abstract: A suspension device of a motor-vehicle wheel includes a support member of the wheel connected to a structure of the motor-vehicle by one or more suspension members and a brake disc connected in rotation with the motor-vehicle wheel. The device also includes a brake disc cover rigidly connected to the support member and at least partially surrounding the brake disc. The brake disc cover is formed in a single piece with said support member of the motor-vehicle wheel.

Abstract: The present invention provides novel crystalline forms of 4-[3-Chloro-4-(N?-cyclopropylureido)phenoxy]-7-methoxyquinoline-6-carboxamide methanesulfonate, as well as methods for their preparation.

Abstract: A brake disc for motor-vehicle disc brakes, includes a body with a hub and two opposite annular planar faces, wherein at least one of these faces is formed with one or more lines defining a surface irregularity, in the form of grooves or ribs, which extend between a radially inner edge and a radially outer edge of the respective face, so as to substantially cover the entire radial extension of the face. A height of the surface irregularity along said lines is less than 0.30 mm, so that during use, the lines defining the surface irregularity disappear, due to wear of the respective face, after an initial fraction of the life of the brake disc. During this initial stage, the lines defining the surface irregularity reduce the time necessary to obtain a bedding of the disc brake with respect to a case of a brake disc devoid of the lines.

Abstract: The present invention relates to a novel crystalline hemihydrate polymorph of neridronic acid sodium salt, and a novel process for the preparation thereof comprising the steps of: 1) dissolving solid sodium neridronate in any crystalline form in water, at a temperature in the range from 70 to 90° C., to obtain an aqueous solution of sodium neridronate; 2) adding a solvent selected from the group consisting in ethanol, 1-propanol, and 2-propanol to the aqueous solution obtained from step (1), so that the final water:solvent volume ratio is in the range from 1:0.5 to 1:1, thus obtaining a suspension; 3) placing the suspension obtained from step (2) under mechanical stirring, at a temperature in the range from 60 to 95° C.; 4) recovering the crystalline hemihydrate form F of sodium neridronate formed in the previous step (3).

Abstract: A vehicle braking system includes an assistance device, having a vacuum pump driven by an engine for communicating vacuum to a chamber of the assistance device. A control valve is interposed along a fluid line between the pump and the chamber. The control valve is in its first operative condition, where the inlet side of the vacuum pump communicates with the chamber, when the pressure within the chamber is above a predetermined value; and is in its second operative condition, where the inlet side of the vacuum pump communicates with the atmosphere, when pressure within the chamber is below a predetermined value. In this second condition the pump intakes air from and feeds air into the atmosphere, thereby reducing the energy consumption by the engine required for driving the pump during stages where, within the chamber there is a vacuum sufficient for the regular operation of the braking system.

Abstract: Disclosed herein is an oxalate salt/co-crystal (tianeptine oxalate) of (RS)-7-(3-chloro-6-methyl-6,11-dihydrodibenzo[c,f] [1,2]thiazepin-11-ylamino)heptanoic acid S,S-dioxide (tianeptine) as shown in Formula I: