Abstract: A microwave-based measuring device includes a number n of sensors, each sensor of the number n of sensors being embodied to generate associated sensor data such that, overall, a number n of items of sensor data are generated by way of the number n of sensors. A measurement variable calculation unit is embodied to calculate a number m of measurement variable values depending on the number n of items of sensor data on the basis of values of a number d of parameters. A learning unit is embodied to calculate the values of the number d of parameters on the basis of training data.

Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.

Abstract: The present invention provides for modified Flavivirus such as a modified Zika virus. The modification according to various aspects of the invention results in reduced viral proteins compared to a parent virus, wherein the reduction in expression is the result of recoding one or more regions of the virus. For example, the prM, or envelope (E) region, or the nonstructural protein 3 (NS3) region or both the E and NS3 regions can be recoded. In various embodiments one or more regions are recoded by reducing the codon pair bias or codon usage bias of the protein-encoding sequence. These modified Flavivirus are used as vaccine compositions to provide a protective immune response.

Abstract: Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K)L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.

Abstract: A radiometric measurement device includes a number n of sensors, wherein a respective sensor of the number n of sensors is configured to generate associated sensor data, such that overall a number n of sensor data is generated by means of the number n of sensors. A measurement variable calculation unit is configured to calculate a number m of measurement variable values depending on the number n of sensor data on the basis of values of a number d of parameters. A learning unit is configured to calculate the values of the number d of parameters on the basis of training data.

Abstract: A radiometric measuring apparatus detects a measured variable in the form of a fill level, a point level, a density and/or a mass flow, and includes a scintillator embodied to generate light pulses upon excitation by ionizing radiation, an optoelectronic sensor embodied to convert the light pulses into a sensor signal, a first signal processing unit embodied to process the sensor signal into a first measured variable signal, an adjustable second signal processing unit embodied in a measurement setting to process the sensor signal into a second measured variable signal, wherein the second measured variable signal corresponds to the first measured variable signal in the case of a correctly processing first signal processing unit and a correctly processing second signal processing unit, and embodied in at least one operation setting to process the sensor signal into at least one operating variable signal, wherein the at least one operating variable signal does not correspond to the measured variable signals, a s

Abstract: A start-stop device and a corresponding method brings about an automatic switch-off and/or switch-on operation of an automatically switched-off drive machine of a motor vehicle, in particular of a motor vehicle having an automatic transmission. The start-stop device has a switch-off logic, by way of which an automatic switch-off of the drive machine can be brought about in the case of a moving vehicle in accordance with a predefined switch-off operating strategy, and a switch-on logic, by way of which an automatic switch-on of the automatically switched-off drive machine can be brought about in accordance with a predefined switch-on operating strategy. The switch-off operating strategy and/or the switch-on operating strategy are/is configured in a manner which is based on wheel torque.

Abstract: Embodiments of a device and method are disclosed. In an embodiment, a method for communicating data frames on a bus that operates according to a multi-master bus protocol is disclosed. The method involves beginning transmission of a data frame from a node on the bus when the node gains control of the bus, wherein the multi-master bus protocol specifies a frame format that includes a start portion, a payload portion, and an end portion, during transmission of the payload portion of the data frame, inserting an in-payload arbitration field into the transmission, continuing transmission of the data frame if the node maintains control of the bus after insertion of the in-payload arbitration field, and halting transmission of the data frame before transmission of the data frame is complete if the node losses control of the bus after insertion of the in-payload arbitration field.

Abstract: This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus.

Abstract: Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K)L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.

Abstract: This invention provides highly attenuated influenza viruses and vaccines. The attenuated viruses and vaccines proliferate well and have high safety factors. The attenuated viruses providing protective immunity from challenge by virus of the same subtype, as well as cross protection against heterologous viruses.

Abstract: This invention provides a modified protein encoding sequence containing nucleotide substitutions at multiple locations in the protein encoding sequence, wherein the substitutions introduce rare hexamers. These hexamers may be Frame Dependent, or depleted in only the reading frame, or Frame Independent, or depleted in all three frames. Modified protein encoding se quences of the present invention may include modified viruses useful for vaccines.

Abstract: Example apparatus are disclosed for a magazine for a self-loading firearm, the magazine comprising a magazine housing, and a magazine floor plate movably mounted to the magazine housing. The magazine floor plate is slidable between an open position and a closed position, wherein the magazine floor plate is pivotable relative to the magazine housing when in the open position.

Abstract: A start/stop device initiates an automatic activation process of an automatically deactivated drive machine of a motor vehicle, in particular of a motor vehicle with an automatic transmission. The drive machine can be automatically deactivated when the motor vehicle is traveling, and the automatically deactivated drive machine can be activated on the basis of driver actions. The start/stop device is configured to initiate an automatic activation of the drive machine which is automatically deactivated when the motor vehicle is traveling on the basis of a detected drive dynamic desired by the driver.

Abstract: A radiometric detector is provided for detecting a measurement variable. The detector is particularly failsafe with, simultaneously, a simple, space-saving and cost-effective design, without having losses in the signal-to-noise ratio.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.