Abstract: A radiometric detector is provided for detecting a measurement variable. The detector is particularly failsafe with, simultaneously, a simple, space-saving and cost-effective design, without having losses in the signal-to-noise ratio.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: This invention provides an attenuated virus comprising a modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein encoding sequence relative to a first host while the codon pair bias relative to a second host is not substantially reduced. In another embodiment, the invention provides an attenuated virus comprising modified viral genome engineered to containing multiple nucleotide substitutions that reduce the codon pair bias of a virus protein-encoding sequence relative to a first host and a second host. The attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the attenuated virus.

Abstract: A radiometric measuring device includes a scintillator, at least one semiconductor photodiode, wherein the at least one semiconductor photodiode is optically coupled to the scintillator, a signal evaluation unit which is electrically coupled to the at least one semiconductor photodiode and is designed to determine a measurement variable on the basis of a measurement signal produced by way of the at least one semiconductor photodiode, and an interface. The radiometric measuring device can be coupled to at least one receiver by way of the interface for the purpose of interchanging data. The radiometric measuring device is designed to be supplied with electrical energy solely via the interface thereof.

Abstract: The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: A measuring object for use in a heating apparatus for the thermal treatment of substrates is described, wherein the measuring object is the substrate to be treated or an object which in use has a substantially known temperature relation to the substrate to be treated, wherein the measuring object comprises a surface having at least one surface area, which acts as a measuring surface for an optical temperature measurement. A predetermined structure in the form of a plurality of recessions is formed in the surface area, in order to influence the emissivity of the surface area.

Abstract: A radiometric detector is provided for detecting a measurement variable. The detector is particularly failsafe with, simultaneously, a simple, space-saving and cost-effective design, without having losses in the signal-to-noise ratio.

Abstract: A radiometric measuring device includes a scintillator, at least one semiconductor photodiode, wherein the at least one semiconductor photodiode is optically coupled to the scintillator, a signal evaluation unit which is electrically coupled to the at least one semiconductor photodiode and is designed to determine a measurement variable on the basis of a measurement signal produced by way of the at least one semiconductor photodiode, and an interface. The radiometric measuring device can be coupled to at least one receiver by way of the interface for the purpose of interchanging data. The radiometric measuring device is designed to be supplied with electrical energy solely via the interface thereof.

Abstract: Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.

Abstract: A radiometric detector is provided for detecting a measurement variable. The detector is particularly failsafe with, simultaneously, a simple, space-saving and cost-effective design, without having losses in the signal-to-noise ratio.

Abstract: A method for automated identification of a state of a sample such as, for example, for identifying whether or not the sample was centrifuged is presented. A device for analyzing samples and a laboratory automation system are also presented in which the method is applied.

Abstract: The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

Abstract: An example system includes a probe to generate ultrasound scans; a user interface to receive inputs from and to provide outputs to a user; and a controller to receive selection of an objective value for each of a plurality of lung sectors of a patient and present an objective lung assessment to the user through the user interface.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: This invention provides an attenuated virus which comprises a modified viral genome containing nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce synonymous deoptimized codons into the genome. The instant attenuated virus may be used in a vaccine composition for inducing a protective immune response in a subject. The invention also provides a method of synthesizing the instant attenuated virus. Further, this invention further provides a method for preventing a subject from becoming afflicted with a virus-associated disease comprising administering to the subject a prophylactically effective dose of a vaccine composition comprising the instant attenuated virus.

Abstract: An example system includes a probe to generate ultrasound scans; a user interface to receive inputs from and to provide outputs to a user; and a controller to receive selection of an objective value for each of a plurality of lung sectors of a patient and present an objective lung assessment to the user through the user interface.

Abstract: A radiometric detector is provided for detecting a measurement variable. The detector is particularly failsafe with, simultaneously, a simple, space-saving and cost-effective design, without having losses in the signal-to-noise ratio.