Abstract: A method for making a bent razor blade is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content less than 0.60% and preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process.

Abstract: The present invention relates to monoclonal antibodies that specifically bind to HER2, or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer specific HER2 binding to the polypeptide. Said antibodies bind to the human Fc receptor and induce FcR mediated signaling pathways. The antibodies according to the invention bind to a different epitope than trastuzumab. The invention also relates to the use of an antibody according to the invention in the treatment of a HER-2 mediated disease. The present invention also relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention, and the use of said composition in the treatment of a HER-2 mediated disease.

Abstract: The present disclosure relates to humanized antibodies that specifically bind to IL-1R3 or a fragment or derivative thereof or a polypeptide that contains at least a portion of said antibody that is sufficient to confer IL-1R3 binding specificity. Said antibodies inhibit IL-1R3 induced NFkB activity. They also inhibit IL-1alpha, IL-1beta, IL-33, and/or IL-36 stimulated NFkB activity. The disclosure further relates to use of said humanized antibody in the treatment of an IL-1R3 mediated disease such as cancer. The disclosure finally encompasses a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of the antibody according to the invention. The pharmaceutical composition can be used in treating a IL-1R3 mediated disease such as cancer.

Abstract: Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule?linkern)m?conjugation partner?(linkero?repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.

Abstract: Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule?linkern)m?conjugation partner?(linkero?repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.

Abstract: A method for operating a rotating-mass device and a rotating mass device of a two-wheeled vehicle are provided. The rotating-mass device includes first and second gyroscopic instruments, each with a cardanically mounted rotating-mass device suitable for generating torque about their respective rotation axes. Pivoting of the rotating-mass devices is coordinated to influence motion of the two-wheeled vehicle about three orthogonal vehicle axes.

Abstract: Monoclonal antibody that specifically binds the interleukin 1 receptor type 1 (IL-1RAcP), or an antigen binding fragment thereof, comprising: a) a heavy chain variable region (VH) comprising CDR1H, CDR2H and/or CDR3H, wherein the CDR1H region comprises an amino acid sequence selected from the group of SEQ ID NO: 155-231, wherein the CDR2H region comprises an amino acid sequence selected from the group of SEQ ID NO: 232-308, and wherein the CDR3H region comprises an amino acid sequence selected from the group of SEQ ID NO: 309-385; and b) a light chain variable region (VL) comprising CDR1L, CDR2L and/or CDR3L, wherein the CDR1L region comprises an amino acid sequence selected from the group of SEQ ID NO: 386-462, wherein the CDRL2 region comprises an amino acid sequence selected from the group of SEQ ID NO: 463-539, and wherein the CDR3L region comprises an amino acid sequence selected from the group of SEQ ID NO: 540-616.

Abstract: The invention relates to production planning systems and methods. A production optimization system is provided which has the following: a production environment with at least one first machine, a second machine, a distribution unit configured to be connected to the first machine and the second machine via a communication network and to ascertain the machine state thereof, and an optimization unit configured to generate a production plan where at least one task for producing a product is separated into machine-specific sub-tasks for the first machine or the second machine, said sub-tasks being provided with a sequence for the first machine or the second machine. The distribution unit ascertains the next occurring sub-task for the first machine or the second machine from the optimization unit while taking into consideration the respective machine state, to remove the sub-task from the production plan, and to assign the sub-task to the respective machine.

Abstract: A drive system for a motor vehicle includes a separating clutch, a shiftable transmission, a drive machine, and a transmission gear wheel and a clutch device. In a first operating state either the clutch device or the transmission gear wheel is kinematically coupled to the transmission input shaft and in a second operating state both said clutch device and said transmission gear wheel are kinematically coupled in said manner thereto. The drive system comprises a braking device for transmitting a braking force in a non-contact manner in this first operating state from a first part to a second part of the braking device. In that the first part of the braking device is kinematically coupleable to the transmission input shaft and the second part is kinematically coupleable to the transmission gear wheel.

Abstract: A roll stand having work rolls mounted therein. The roll stand has at least one upper mounting rail, which is mounted on the drive-side roll stand frame and oriented in a transverse direction to a rolling line running through the roll stand. In order to be able to keep the assembly space in the roll stand over the rolling line free during rolling—except for a roll change—and still change the roll efficiently, the upper mounting rail is configured to be moved into the rolling line and out of the rolling line, starting from the drive-side roll stand frame.

Abstract: A communication platform exchanges digital data within a value added chain by at least one order. Each individual order corresponds to a collaborative process and has an order structure. The collaborative process and order structure digital data are usable in communication platform modules. The communication platform also has an order structure module configuring at least one such order structure and allocating to one or more user groups for each order structure authorization to generate and/or accept such order; a client module generating, providing or releasing at least one such order, or allocating at least one user group ID to the order(s); a contractor module confirming, declining, or accepting such order and adapting the order status information; and a generic application programming interface connecting the communication platform modules such that order structure digital data is usable in all modules, and any order structure orders can be interconnected.

Abstract: A method for making a bent razor blade is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content less than 0.60% and preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process.

Abstract: A diaphragm for a container assembly for dispensing products such as wipes or sheets, or collecting and/or storing products, including waste products. The container assembly has diaphragm with a central aperture and at least one petal. The diaphragm is a portion of the lid or the container. The aperture allows a user to insert one or more fingers (or hand) to pull the first sheet out or alternatively, deposit an item into the container. The diaphragm has one or more slits separating the outer periphery of the diaphragm from portions of the petals, thereby reducing the force required to deflect the diaphragm.

Abstract: A vehicle rim is provided having a rim body and at least one capacitor. The rim body has a hub region, a rim bed and a connection region that connects the hub region to the rim bed. The rim body forms at least a part of a housing of the capacitor.

Abstract: In the case of a method or an arrangement for the automatic start up of a first communication terminal (EG A, EG B) configured for voice communication on at least one second communication terminal (CL A, CL B) configured for text communication, the voice communication between communication terminals is conveyed via at least one voice communication server (SCS) and the text communication between communication terminals is conveyed via at least one text communication server (TCS). The at least one voice communication server (SCS) and the at least one text communication server (TICS) exchange information via at least one conversion device (GW). The start up of at least one first communication terminal (CL A, CL B) is effected via the at least one text communication server (TCS), the at least one conversion device (GW) and the at least one voice communication server (SCS) to at least one second voice communication terminal (EG A, EG B).

Abstract: A method for making a bent razor blade is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content less than 0.60% and preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process.

Abstract: Disclosed herein are antibodies and uses thereof. Disclosed herein are monoclonal antibodies characterized in specifically binding to three, four or five antigens e.g. human c-Met, IGF-IR, EGFR, HER2 and/or HER3. Disclosed herein are antibodies useful for the manufacture of a pharmaceutical composition and for the treatment of cancer, especially breast, colon, lung, or pancreatic cancer. Also disclosed herein are methods of using immunization of rabbits and selection of single B cells for the production of the disclosed antibodies.

Abstract: A method for producing an endless transport belt for guiding substrates during the printing operation of a printing press is disclosed. The ends of a transport belt are welded together. The transport belt is ground, after one or multiple welding operations without or with the addition of material, to a nominal thickness that is smaller than or equal to the minimal thickness of the transport belt.

Abstract: A printing press with at least one gripperless printing unit of a reel-fed printing press, through which a substrate to be printed can be transported in the horizontal direction by a transport device. A dimensionally stable and relatively stiff piece good, which during the transport and printing does not adapt to cylinder contours of the printing units, can be transported through the or each gripperless printing unit by the transport device. The printing press further includes a feeder, which keeps the piece good to be printed ready and via which the piece good to be printed can be circumference register-precisely and page register-precisely placed on the transport device for the subsequent printing in the printing units.

Abstract: The present invention relates to a stripper (11) for a work roll of a rolling stand, in particular a hot rolling stand, wherein the stripper tip (11) has a stripper tip (5) that makes a contact with the work roll (1), and a first screening element (8) for screening a rolled material (10) from cooling water of the rolling stand, wherein there is provided a second screening element (6) for screening the first screening element (8) from being thermally loaded by the rolled material (10).