Abstract: In the case of a method or an arrangement for the automatic start up of a first communication terminal (EG A, EG B) configured for voice communication on at least one second communication terminal (CL A, CL B) configured for text communication, the voice communication between communication terminals is conveyed via at least one voice communication server (SCS) and the text communication between communication terminals is conveyed via at least one text communication server (TCS). The at least one voice communication server (SCS) and the at least one text communication server (TCS) exchange information via at least one conversion device (GW). The start up of at least one first communication terminal (CL A, CL B) is effected via the at least one text communication server (TCS), the at least one conversion device (GW) and the at least one voice communication server (SCS) to at least one second voice communication terminal (EG A, EG B).

Abstract: Method for the production of IGF-I, characterized by cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding a fusion protein comprising said IGF-I N-terminally linked to the C-terminus of a propeptide, whereby said propeptide ends C-terminally with amino acids -Y-Pro, wherein Y is selected from the group consisting of Pro, Pro-Ala, Pro-Gly, Pro-Thr, Ala-Pro, Gly-Pro, Thr-Pro, Arg-Pro, or Pro-Arg-Pro, recovering and cleaving said fusion protein with IgA protease, and recovering said IGF-I. IGF-I is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.

Abstract: A method of making a razor cartridge is provided. A housing of the razor cartridge has an elongated body having, integrally formed, a guard, a cap and an interior wall extending between the guard and the cap close to an end of the elongated body. An exterior wall extends outwardly of the interior wall and is joined to the interior wall by a film hinge. A portion of a body of a razor blade is positioned in a slot of the interior wall. The exterior wall is folded about the film hinge so that a lip of the exterior wall overlays an end portion of the cutting edge of the razor blade to secure to razor blade within the housing. The exterior wall is additionally secured to the elongated body. A razor cartridge is thus provided.

Abstract: The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant.

Abstract: The invention relates to a device (1) for cooling a metal strip (2) between two rolling stands (3), wherein the strip (2) is led over a leading-over element (4) of a flat form and arranged under the leading-over element (4) is a spraying element (5), which directs cooling medium (7) onto the underside (8) of the strip (2) through at least one opening (6) in the leading-over element (4). To achieve an improved spray pattern, the invention provides that at least two openings (6) are introduced into the leading-over element (4), said openings being arranged next to each other in a direction transverse (Q) to the conveying direction (F) of the strip (2) and having an elongated form, wherein the longitudinal axis (9) of the opening (6) is aligned at an angle (?) with respect to the conveying direction (F) of the strip.

Abstract: The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant.

Abstract: Herein are reported glycosylated repeat-motif-molecule conjugate of the following formula: (repeat-motif-molecule?linkern)m?conjugation partner?(linkero?repeat-motif-molecule)p, wherein n and o are independently of each other and independently for each value of m and p integer values of 0 or 1, and m and p are independently of each other integer values of 0 or 1 or 2 or 3 or 4 or 5 or 6 or 7, and wherein the repeat-motif-molecule conjugate comprises at least one oligosaccharide attached to a glycosylation site. Also reported are encoding nucleic acids and method for producing these repeat-motif-conjugates in mammalian cells.

Abstract: A method for making a razor blade having a bent portion is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process. When the razor blade is bent to define an included angle of 90 degrees between planar regions adjacent the bent portion and an inner surface having a radius about 0.3-0.35 mm, the outer surface of the bent portion is free from macro-cracks.

Abstract: A razor cartridge is provided with a skin engaging structure at the cap and/or guard surface of the razor cartridge. The skin engaging structure has an array of closely spaced elongated protrusions integrally formed with a substrate. In use, the protrusions produce a pleasant tactile sensation tending to reduce shaving discomfort. The protrusions are formed by closely packed molded flexible filaments that can be less than 0.25 mm wide and have spacing between adjacent protrusions less than 0.2 mm. The protrusions can have a density greater than 5 protrusions per mm2. The skin engaging structure can be molded from e.g. an olefin polymer. The substrate can be integrally formed with a housing of the razor cartridge.

Abstract: The invention relates to a reversing roll stand (20), in particular a Steckel reversing roll stand (20), with at least one upper backing roll and one lower backing roll (2, 4) and one respective upper and one respective lower working roll (1 and 3); and with on the input side and on the output side of the stand respective upper supports (8) juxtaposed with the upper working roll (1) and connected to an upper-roll frame via a first actuator (6). In a deviating position from the upper support (8) a respective hinge-mounted upper scraper (11) for the upper working roll (1) is pivotally movable against the upper working roll (1) by a respective second actuator (12) carried on each of the upper supports (8). The upper supports (8) are each displaceable in respective lower and upper vertical guides (9, 10) such that the respective first actuator (6) can draw it out of the lower vertical guide (9) and it can be pivoted by a third actuator (7) outward from the upper working roll (1).

Abstract: The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of said anti-CCR5 antibody and to the pharmaceutical use of said conjugate.

Abstract: The current invention is related to a conjugate comprising one or more antifusogenic peptides and an anti-CCR5 antibody (mAb CCR5) characterized in that one to eight antifusogenic peptides are each conjugated to one terminus of the heavy and/or light chains of the anti-CCR5 antibody and to the pharmaceutical use of the conjugate.

Abstract: The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant.

Abstract: Method for the production of IGF-I, characterized by cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding a fusion protein comprising said IGF-I N-terminally linked to the C-terminus of a propeptide, whereby said propeptide ends C-terminally with amino acids -Y-Pro, wherein Y is selected from the group consisting of Pro, Pro-Ala, Pro-Gly, Pro-Thr, Ala-Pro, Gly-Pro, Thr-Pro, Arg-Pro, or Pro-Arg-Pro, recovering and cleaving said fusion protein with IgA protease, and recovering said IGF-I. IGF-I is useful for the treatment of neurodegenerative disorders like Alzheimer's Disease.

Abstract: A method for making a razor blade having a bent portion is disclosed. The method includes: providing an elongated strip of stainless steel that can be 0.076 mm thick; hardening the strip; providing a cutting edge along an edge of the strip and providing coating(s) on the cutting edge. The stainless steel has a carbon content preferably between 0.45% and 0.55% by weight. The strip is separated lengthwise into discrete razor blades. The bent portion of the razor blade is then formed using a swivel bending process. When the razor blade is bent to define an included angle of 90 degrees between planar regions adjacent the bent portion and an inner surface having a radius about 0.3-0.35 mm, the outer surface of the bent portion is free from macro-cracks.

Abstract: The present invention is a razor blade carrier having a base with at least two stepped protrusion extending outwardly therefrom. The stepped protrusion define at least two landing positions that support a portion of the razor blade. The landing surfaces of the stepped protrusions cooperate to define at least two razor blade locations. The razor blade carrier is used in a razor cartridge.

Abstract: The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant.

Abstract: The invention relates to a device (1) for cooling a metal strip (2) between two rolling stands (3), wherein the strip (2) is led over a leading-over element (4) of a flat form and arranged under the leading-over element (4) is a spraying element (5), which directs cooling medium (7) onto the underside (8) of the strip (2) through at least one opening (6) in the leading-over clement (4). To achieve an improved spray pattern, the invention provides that at least two openings (6) are introduced into the leading-over element (4), said openings being arranged next to each other in a direction transverse (Q) to the conveying direction (F) of the strip (2) and having an elongated form, wherein the longitudinal axis (9) of the opening (6) is aligned at an angle (?) with respect to the conveying direction (F) of the strip.

Abstract: The present invention relates to a fusion protein comprising IGF-I or an IGF-I variant N-terminally linked to the C-terminus of a propeptide. The invention relates also to a method involving the use of the aforementioned fusion protein in the production of a lysine-PEGylated IGF-I or IGF-I variant. The method comprises the steps of cultivating a prokaryotic host cell comprising an expression vector containing a nucleic acid encoding the fusion protein and causing the cell to express the fusion protein, recovering and PEGylating said fusion protein, cleaving said PEGylated fusion protein with IgA protease, and recovering lysine-PEGylated IGF-I or IGF-I variant. The invention relates also to a lysine-PEGylated IGF-I or IGF-I variant produced using the above method. In addition, the invention relates to a method for treating a neurodegenerative disorders like Alzheimer's Disease using the lysine-PEGylated IGF-I or IGF-I variant and a composition comprising the lysine-PEGylated IGF-I or IGF-I variant.

Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.