Abstract: The present invention encompasses compounds of formula (I) wherein the groups A, R and q are defined in claim 1, their use as inhibitors of IGF-1 R, pharmaceutical compositions which contain compounds of this kind and their use as medicaments, especially as agents for treatment and/or prevention of oncological diseases.

Abstract: This disclosure relates to systems and methods for controlling electrical loads in one or more areas. The system includes a room controller having a microprocessor for accessing data and providing commands, memory for storing information operably connected to the microprocessor, a relay for powering a load based on commands from the microprocessor, and a port for connecting a peripheral device. The system also includes a peripheral device connected to the port and configured to send data to the controller indicating the type of peripheral device; and a load connected to the relay.

Abstract: A method of controlling a lubricator apparatus, according to one illustrative embodiment, comprises: receiving a signal representing rotation of a lubricant applicator in rotatable engagement with an object to be lubricated; and causing the lubricator apparatus to dispense lubricant through the lubricant applicator to the object to be lubricated in response to the signal. A method of communication, according to another illustrative embodiment, comprises: receiving, at a communication apparatus, a plurality of input operational property signals; transmitting an output operational property signal from the communication apparatus to a data collection apparatus, the output operational property signal representing at least one of the measurements; receiving, at the communication apparatus, an input control signal; and controlling at least one device of the system in response to the input control signal.

Abstract: A fluid holder includes: a housing having an inner surface and at least one fluid outlet; a piston in slidable engagement with the inner surface and having first and second opposed surfaces with a threaded opening extending therebetween, the first surface of the piston and the inner surface of the housing defining a fluid chamber in communication with the at least one fluid outlet; and a threaded member engageable with the threaded opening, a first portion of the threaded member extending from the first surface of the piston, the threaded member being rotatably coupled to the housing on the first portion of the threaded member for rotation in the threaded opening of the piston such that rotation of the threaded member causes a force to be exerted by the threaded member on the housing and on the piston to expand or contract the fluid chamber.

Abstract: The invention describes dual Aurora kinase/MEK inhibitors and their use in therapy.

Abstract: A fluid holder includes: a housing having an inner surface and at least one fluid outlet; a piston in slidable engagement with the inner surface and having first and second opposed surfaces with a threaded opening extending therebetween, the first surface of the piston and the inner surface of the housing defining a fluid chamber in communication with the at least one fluid outlet; and a threaded member engageable with the threaded opening, a first portion of the threaded member extending from the first surface of the piston, the threaded member being rotatably coupled to the housing on the first portion of the threaded member for rotation in the threaded opening of the piston such that rotation of the threaded member causes a force to be exerted by the threaded member on the housing and on the piston to expand or contract the fluid chamber.

Abstract: A fluid holder includes: a housing having an inner surface and at least one fluid outlet; a piston in slidable engagement with the inner surface and having first and second opposed surfaces with a threaded opening extending therebetween, the first surface of the piston and the inner surface of the housing defining a fluid chamber in communication with the at least one fluid outlet; and a threaded member engageable with the threaded opening, a first portion of the threaded member extending from the first surface of the piston, the threaded member being rotatably coupled to the housing on the first portion of the threaded member for rotation in the threaded opening of the piston such that rotation of the threaded member causes a force to be exerted by the threaded member on the housing and on the piston to expand or contract the fluid chamber.

Abstract: A method of controlling a lubricator apparatus, according to one illustrative embodiment, comprises: receiving a signal representing rotation of a lubricant applicator in rotatable engagement with an object to be lubricated; and causing the lubricator apparatus to dispense lubricant through the lubricant applicator to the object to be lubricated in response to the signal. A method of communication, according to another illustrative embodiment, comprises: receiving, at a communication apparatus, a plurality of input operational property signals; transmitting an output operational property signal from the communication apparatus to a data collection apparatus, the output operational property signal representing at least one of the measurements; receiving, at the communication apparatus, an input control signal; and controlling at least one device of the system in response to the input control signal.

Abstract: The present invention encompasses compounds of general formula (1) wherein the groups R1 to R4, X1, X2, X3, L1 and L2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof in such a treatment.

Abstract: The invention describes dual Aurora kinase/MEK inhibitors and their use in therapy.

Abstract: A crystalline form of 3-{3-[1-(4-Dimethylaminomethyl-phenylamino)-1-phenyl-meth-(Z)-ylidene]-2-oxo-2,3-dihydro-1H-indol-6-yl}-propynoic acid ethylamide.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, Rg, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: The present invention encompasses compounds of general formula (I) wherein the groups R5 to R10, A, L1, B, m and p are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

Abstract: A method for the automatic detection of at least one property of at least one replaceable component of an apparatus for the production of printed products is disclosed and such an apparatus and a system for the production of printed products are disclosed. The property of the component of the apparatus or of the system is detected by using an electronic device for a wireless detection of component-related data.

Abstract: The present invention encompasses compounds of general formula (I) wherein the groups R5 to R10, A, L1, B, m and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, pharmaceutical preparations which contain such compounds and their use as medicaments.

Abstract: The present invention encompasses compounds of general formula (1) wherein R1 to R4 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.

Abstract: The invention relates to a heat exchange device including at least two tubes (12) for circulating a heat transfer fluid arranged in at least two rows (R1, R2) offset two-by-two from one row to the other. A heat exchange fin (20) and a heat storage tank (22) made from a heat storage material extend transversely to the rows of the tubes (R1, R2) forming a group of tanks and tubes (24) in each instance, wherein a single heat storage tank (22) is in contact with one tube (12) of each row of tubes (R1, R2). The contact with the tubes (12) takes place alternately on two opposing walls (26, 28) of the heat storage tank (22), and the walls (26, 28) are also in contact with spacers fins (20). The invention can be used for the air-conditioning evaporators of automobiles.

Abstract: The present invention encompasses compounds of general Formula (1) wherein R2, R3, Q, W, X, Y and Z are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.