Abstract: A method of determining a clinical value for an individual based on a tumor in an image by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to determine a lymphocyte distribution of lymphocytes in the tumor based on the image; apply a classifier to the lymphocyte distribution to classify the tumor, the classifier having been trained to classify tumors into a class selected from at least two classes respectively associated with lymphocyte distributions; and determine the clinical value for the individual based on prognoses of individuals with tumors in the class into which the classifier classified the tumor.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: There are provided methods for preparing lithium carbonate. For example, such methods can comprise reacting an aqueous composition comprising lithium hydroxide with CO2 by sparging the CO2 the said composition, thereby obtaining a precipitate comprising the lithium carbonate. The methods can also comprise inserting at least a portion of the precipitate into a clarifier and obtaining a supernatant comprising lithium bicarbonate and a solid comprising the lithium carbonate, separating the solid from the supernatant; and heating the supernatant at a desired temperature so as to at least partially convert the lithium bicarbonate into lithium carbonate.

Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

Abstract: A computer implemented method for event management and participation, comprises providing a timeslot rules table, the timeslot rules table being an immutable table of a first plurality of timeslots, the timeslot rules table defining a plurality of scheduling rules. The method further comprises providing a timeslot additions table, the timeslot additions table including a second plurality of timeslots being different from the first plurality of timeslots. The method further comprises providing a calendar recurring rule table, the calendar recurring rule table including recurring pattern rules for one or more of the timeslot rules table and the timeslot additions table. The method further comprises providing an exceptions table, the exceptions table including one or more exceptions to the scheduling rules. The method further comprises providing efficient data storage that can span tens of thousands of “tenants” or customers all having complex multi-day timeslot data in the same computer system.

Abstract: A system and a method for generating and displaying candidate virtual interline routes for travel between an origin location and a destination location. The system identifies a set of candidate virtual interline routes based on the origin location and the destination location, each including multiple segments offered by different carriers that lack an interline agreement. Each route is associated with a weight determined based on historical data including user input. The routes are ranked based on the weights, and a subset is selected. The system retrieves from external data providers up-to-date data associated with the subset of candidate virtual interline routes, and displays the up-to-date data on a client device of a user.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: A method of determining a region of interest in an image of tissue of an individual by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to partition an image of tissue of an individual into a set of areas, identify a tissue type of each area of the image, and apply a classifier to the image to determine a region of interest, the classifier being configured to determine regions of interest based on the tissue types of the set of areas of the image.

Abstract: A method of determining a clinical value for an individual based on a tumor in an image by an apparatus including processing circuitry may include executing, by the processing circuitry, instructions that cause the apparatus to determine a lymphocyte distribution of lymphocytes in the tumor based on the image; apply a classifier to the lymphocyte distribution to classify the tumor, the classifier having been trained to classify tumors into a class selected from at least two classes respectively associated with lymphocyte distributions; and determine the clinical value for the individual based on prognoses of individuals with tumors in the class into which the classifier classified the tumor.

Abstract: Methods for preparing spray dried lactose are provided. Methods include concentrating an aqueous lactose source, crystallizing at least a portion of the lactose in the concentrated lactose source, and forming a crystallized lactose slurry comprising a plurality of lactose particles. Methods include washing the crystallized lactose slurry for a period of time sufficient to reduce an absolute value of a b*-value color of the lactose particles by greater than or about 75%. Methods include wet milling the crystallized lactose slurry, reducing a D50 particle size of the plurality of lactose particles by greater than or about 50%. Methods include spray drying the crystallized lactose slurry, forming a plurality of spray dried lactose particles.

Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.

Abstract: Techniques are described for a computing system to synchronize project data between media applications. A method includes (a) operating a first project adapter module to convert a first media project generated by a first media application from a first project format into a generalized project format, thereby generating a generalized project; (b) operating a synchronization service to manage a set of contextual rules; (c) operating a second project adapter module to convert, with reference to the set of contextual rules, the generalized project into a second project format used by a second media application, thereby generating a second media project; and (d) viewing the second media project using the second media application. A system, apparatus, and computer program product for performing this method and similar methods are also described.

Abstract: An intraluminal imaging device is provided. In one embodiment, the imaging device includes a flexible elongate member that may be inserted into a body lumen within a patient. The flexible elongate member may define a longitudinal axis. The imaging device also has an imaging assembly that is disposed at a distal portion of the flexible elongate member. The imaging assembly may have a plurality of ultrasound transducer elements disposed around the longitudinal axis. The imaging assembly further includes a first integrated circuit controller in communication with the plurality of ultrasound transducer elements. The first integrated circuit controller may be annularly shaped. In some embodiments, the imaging assembly may include a second integrated circuit controller in communication with the ultrasound transducer elements and the first integrated circuit controller. The second integrated circuit controller may be annularly shaped.

Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

Abstract: There are provided processes comprising submitting an aqueous composition comprising lithium sulphate and/or bisulfate to an electrolysis or an electrodialysis for converting at least a portion of said sulphate into lithium hydroxide. During electrolysis or electrodialysis, the aqueous composition is at least substantially maintained at a pH having a value of about 1 to about 4; and converting said lithium hydroxide into lithium carbonate.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: An intraluminal medical imaging interface device includes an arm assembly comprising one or more longitudinal members and one or more joints coupled to the one or more longitudinal members, and a head assembly coupled to a distal portion of the arm assembly and comprising a proximal portion coupled to the distal portion of the arm assembly and a distal portion. The distal portion of the head assembly includes a mechanical coupling and an electrical coupling configured to separably connect to an intraluminal imaging catheter and to transmit electrical signals between a console and the intraluminal imaging catheter. The arm assembly is configured to couple to a surface to maintain the head assembly at a first position and an orientation with respect to a patient without continued support by an operator. Associated devices, systems, and methods are also provided.

Abstract: The invention provides a method of validating the therapeutic composition that is prepared for immunotherapy of a tumor or cancer. The method includes, triggering of an immune response to a neoepitope of a subject's tumor by: a) obtaining neoepitope sequence data from the tumor of a subject; b) obtaining immune competent cells; c) using the neoepitope sequence data to generate a neoepitope presentation system; d) triggering an immune response by contacting the immune competent cells with the neoepitope presentation system; and e) quantifying the triggering of the immune response from the contacted immune competent cells.

Abstract: Described are automated guided vehicles (AGVs) that can autonomously engage and transport a payload carrier in a human collaborative materials handling facility environment. Embodiments of the present disclosure can be deployed in various materials handling facilities (e.g., a sortation facility, a cross dock center, a fulfillment center, a warehouse, a delivery center, etc.) to facilitate efficient and automated transport of a payload carrier, such as a cart, alongside human workers in unstructured, collaborative environments. Further, the exemplary autonomous vehicle of the present disclosure can engage payload carriers (e.g., carts, etc.) in various configurations and orientations to facilitate multiple modes of transport.

Abstract: A method of leaching copper-containing ores, such as chalcopyrite ores, with a leach liquor in the presence of silver and an activation agent that activates silver whereby the silver enhances copper extraction from copper ores.