Patents by Inventor Stephen A. Charles

Stephen A. Charles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9044516
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: June 2, 2015
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20150050714
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: August 11, 2014
    Publication date: February 19, 2015
    Applicant: OLIGASIS, LLC
    Inventor: Stephen A. Charles
  • Publication number: 20150004128
    Abstract: The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
    Type: Application
    Filed: April 29, 2014
    Publication date: January 1, 2015
    Applicant: Oligasis, LLC
    Inventors: Stephen A. Charles, D. Victor Perlroth
  • Patent number: 8846021
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Grant
    Filed: August 5, 2013
    Date of Patent: September 30, 2014
    Assignee: Oligasis, LLC
    Inventor: Stephen A. Charles
  • Publication number: 20140227218
    Abstract: Pharmaceutical compositions of conjugates are provided. The conjugates can be prepared by (among other ways) conjugating a pharmacologically active agent with a polymeric reagent that has a particular arrangement of atoms. Related methods, preparations, and so forth are also provided.
    Type: Application
    Filed: December 20, 2013
    Publication date: August 14, 2014
    Applicant: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 8765432
    Abstract: The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: July 1, 2014
    Assignee: Oligasis, LLC
    Inventors: Stephen A. Charles, D. Victor Perlroth
  • Publication number: 20140024776
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.
    Type: Application
    Filed: May 23, 2013
    Publication date: January 23, 2014
    Applicant: Oligasis
    Inventors: Stephen A. Charles, Victor D. Perlroth, Didier G. Benoit, Lane A. Clizbe, Wayne To, Linda J. Zadik, Jeanne M. Pratt
  • Patent number: 8633277
    Abstract: Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: January 21, 2014
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20130337534
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: August 5, 2013
    Publication date: December 19, 2013
    Applicant: Oligasis, LLC
    Inventor: Stephen A. Charles
  • Publication number: 20130045522
    Abstract: The present invention provides random copolymers containing zwitterions and one or more functional agents, and methods of preparing such random copolymers.
    Type: Application
    Filed: December 20, 2010
    Publication date: February 21, 2013
    Applicant: Oligasis
    Inventors: Stephen A. Charles, D. Victor Perlroth, Lane A. Clizbe, Didier G. Benoit, Wayne To
  • Publication number: 20130034517
    Abstract: The present invention provides random copolymers containing phosphorylcholine and one or more functional agents, and methods of preparing such random copolymers.
    Type: Application
    Filed: May 10, 2010
    Publication date: February 7, 2013
    Applicant: Oligasis
    Inventors: Stephen A. Charles, D. Victor Perlroth
  • Publication number: 20110178242
    Abstract: Methods for preparing polymer-drug conjugates are provided. The disclosed methods involve polymeric reagents comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. Related methods, compositions, preparations, and so forth are also provided.
    Type: Application
    Filed: March 8, 2011
    Publication date: July 21, 2011
    Applicant: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 7947261
    Abstract: Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: May 24, 2011
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Patent number: 7887789
    Abstract: Polymeric reagents are provided comprising a moiety of atoms arranged in a specific order, wherein the moiety is positioned between a water-soluble polymer and a reactive group. The polymeric reagents are useful for, among other things, forming polymer-active agent conjugates. Related methods, compositions, preparations, and so forth are also provided.
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: February 15, 2011
    Assignee: Nektar Therapeutics
    Inventors: J. Milton Harris, Antoni Kozlowski, Samuel P. McManus, Michael D. Bentley, Stephen A. Charles
  • Publication number: 20100166700
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: February 28, 2007
    Publication date: July 1, 2010
    Applicant: OLIGASIS CORPORATION
    Inventor: Stephen A. Charles
  • Patent number: 6087462
    Abstract: Polymers of one or more radical polymerisable monomers which polymer has pendant groups bearing a centre of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment of surfaces to render them biocompatible. The polymers may contain pendant groups which bind the polymer to a surface by physisorption, covalent bonding or ionic interactions. Additionally reactive groups in the polymer may serve as points for attachment of ligands to the polymer when coated on a surface.
    Type: Grant
    Filed: May 12, 1998
    Date of Patent: July 11, 2000
    Assignee: Biocompatibles Limited
    Inventors: Roderick W J Bowers, Stephen A Jones, Peter W Stratford, Stephen A Charles
  • Patent number: 5798117
    Abstract: A method of reducing the extent to which microorganisms, particularly bacteria, will adhere to a surface, which comprises providing a surface having pendant groups of formula (I), in which each group R is the same or different and is alkyl of 1 to 4 carbon atoms and a is from 1 to 4, use of compounds containing a group of formula (I) in reducing the extent to which microorganisms would adhere to a surface and use of articles comprising such surfaces in environments susceptible to microorganism adhesion. The method has application in a wide variety of industrial or domestic fields wherever it is desirable to prevent growth of microorganisms as well as in the medical field.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: August 25, 1998
    Assignee: Biocompatibles Limited
    Inventors: Roger R C New, Stephen A Charles, Ewan J Campbell
  • Patent number: 5783650
    Abstract: Polymers of one or more radical polymerisable monomers which polymer has pendant groups bearing a centre of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment of surfaces to render them biocompatible. The polymers may contain pendant groups which bind the polymer to a surface by physisorption, covalent bonding or ionic interactions. Additionally reactive groups in the polymer may serve as points for attachment of ligands to the polymer when coated on a surface.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 21, 1998
    Assignee: Biocompatibles Limited
    Inventors: Roderick W. J. Bowers, Stephen A. Jones, Peter W. Stratford, Stephen A. Charles
  • Patent number: 5705583
    Abstract: Polymers of one or more radical polymerisable monomers which polymer has pendant groups bearing a center of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment of surfaces to render them biocompatible. The polymers may contain pendant groups which bind the polymer to a surface by physisorption, covalent bonding or ionic interactions. Additionally reactive groups in the polymer may serve as points for attachment of ligands to the polymer when coated on a surface.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 6, 1998
    Assignee: Biocompatibles Limited
    Inventors: Roderick W. J. Bowers, Stephen A. Jones, Peter W. Stratford, Stephen A. Charles
  • Patent number: 5556710
    Abstract: Compounds of formula (I), in which the groups R are hydrogen or C.sub.1-4 alkyl, n is from 2 to 4, X is alkylene, poly(ethoxy) or an aryl-containing group, Y is a valence bond or a divalent functional or heterocyclic group or a trivalent alkylene group, and Z is a sulphur-containing group which contains a thiol or disulphide group are useful to provide biocompatible treatments of metal surfaces, such as silver and gold surfaces. Processes for the preparation of the compounds, intermediates useful in such processes, articles having a metal surface treated with such compounds and processes of rendering metal surfaces biocompatible which comprise treating the metal surfaces with them.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: September 17, 1996
    Assignee: Biocompatibles Limited
    Inventors: Jeremy C. Russell, Yiannakis P. Yianni, Stephen A. Charles