Patents by Inventor Stephen A. Charles

Stephen A. Charles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acryloyloxyethylphosphorylcholine Containing Polymer Conjugates And Their Preparation
    Publication number: 20220096643
    Abstract: The present invention relates to polymeric reagents and conjugates thereof, methods for synthesizing the polymeric reagents and conjugates, pharmaceutical compositions comprising the conjugates and methods of using the polymer conjugates including therapeutic methods where conjugates are administered to patients.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 31, 2022
    Inventor: Stephen A. Charles
  • Handle for a razor
    Patent number: 11285630
    Abstract: A razor handle for a razor cartridge is provided. The handle comprises a head, a body, a cover layer, and a clip member. The head has a cartridge engaging end and an attachment end. The body has a front end and a rear end and comprises a first shell and a second shell that are releasably coupled together. The front end is coupled with the attachment end. The cover layer at least partially surrounds the body. The clip member is coupled with the first shell and the second shell at the rear end of the body such that the first and second shells are held together at least partially by the clip member. The clip member has a plurality of features which are coupled to a plurality of features on the body. These are retention features such as recesses or projections.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: March 29, 2022
    Assignee: The Gillette Company LLC
    Inventors: Hong Lu, Stephen Charles Witkus, Alexander Stephen Forti, Huibin Gong
  • OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF
    Publication number: 20220088098
    Abstract: Methods of inhibiting or reducing tumor growth are disclosed. A composition containing at least one selected oncolytic virus is administered within a tumor of a patient. The virus kills cancerous cells and induces a systemic and lasting anti-tumor immunity that is also compatible with other cancer treatments. Also disclosed are methods of creating synthetic viruses for targeting cancerous tumors.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Peter M. Chumakov, Anastasia V. Lipatova, Stepan P. Chumakov, Natalia D. Tararova, Stephen A. Charles, Anton A. Komar
  • OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF
    Publication number: 20220088097
    Abstract: Methods of inhibiting or reducing tumor growth are disclosed. A composition containing at least one selected oncolytic virus is administered within a tumor of a patient. The virus kills cancerous cells and induces a systemic and lasting anti-tumor immunity that is also compatible with other cancer treatments. Also disclosed are methods of creating synthetic viruses for targeting cancerous tumors.
    Type: Application
    Filed: December 6, 2021
    Publication date: March 24, 2022
    Inventors: Peter M. Chumakov, Anastasia V. Lipatova, Stepan P. Chumakov, Natalia D. Tararova, Stephen A. Charles, Anton A. Komar
  • Tumor antigenicity processing and presentation
    Patent number: 11276479
    Abstract: Methods for targeting a tumor antigen for immunotherapy based on HLA allele type and the mutations present in the tumor antigen are presented. A patient's HLA allele type and a tumor antigen derived from a mutation in cancer driver gene can be matched with a majority allele type having a minimum affinity to the same tumor antigen or with those of a plurality of patients with a history of cancer treatment. Upon matching, a cancer treatment against the tumor antigen can be selected and administered to the patient to achieve a desired effect.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: March 15, 2022
    Assignees: Nantomics, LLC, Nant Holdings IP, LLC
    Inventors: Andrew Nguyen, John Zachary Sanborn, Charles Joseph Vaske, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Stephen Charles Benz
  • Optimized oncolytic viruses and uses thereof
    Patent number: 11253558
    Abstract: Methods of inhibiting or reducing tumor growth are disclosed. A composition containing at least one selected oncolytic virus is administered within a tumor of a patient. The virus kills cancerous cells and induces a systemic and lasting anti-tumor immunity that is also compatible with other cancer treatments. Also disclosed are methods of creating synthetic viruses for targeting cancerous tumors.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: February 22, 2022
    Inventors: Peter M. Chumakov, Anastasia V. Lipatova, Stepan P. Chumakov, Natalia D. Tararova, Stephen A. Charles, Anton A. Komar
  • Processes for preparing lithium carbonate
    Patent number: 11254582
    Abstract: There are provided methods for preparing lithium carbonate. For example, such methods can comprise reacting an aqueous composition comprising lithium hydroxide with CO2 by sparging the CO2 the said composition, thereby obtaining a precipitate comprising the lithium carbonate. The methods can also comprise inserting at least a portion of the precipitate into a clarifier and obtaining a supernatant comprising lithium bicarbonate and a solid comprising the lithium carbonate, separating the solid from the supernatant; and heating the supernatant at a desired temperature so as to at least partially convert the lithium bicarbonate into lithium carbonate.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: February 22, 2022
    Assignee: NEMASKA LITHIUM INC.
    Inventors: Guy Bourassa, Gary Pearse, Stephen Charles Mackie, Mykolas Gladkovas
  • OXYGEN REDUCTION REACTION CATALYST
    Publication number: 20220029172
    Abstract: A method for the manufacture of an oxygen reduction reaction (ORR) catalyst, the method comprising; providing a metal organic framework (MOF) material having a specific internal pore volume of 0.7 cm3g?1 or greater; providing a source of iron and/or cobalt; pyrolysing the MOF material together with the source of iron and/or cobalt to form the catalyst, wherein the MOF material comprises nitrogen and/or the MOF material is pyrolysed together with a source of nitrogen and the source of iron and/or cobalt is disclosed.
    Type: Application
    Filed: October 7, 2021
    Publication date: January 27, 2022
    Inventors: Marie Josephe Vanessa ARMEL, Stephen Charles BENNETT, Frederic Christophe JAQUEN, Deborah JONES, Sheena HINDOCHA, Fabrice SALLES
  • Healthcare Object Recognition, Systems And Methods
    Publication number: 20220028508
    Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.
    Type: Application
    Filed: October 5, 2021
    Publication date: January 27, 2022
    Inventors: Patrick SOON-SHIONG, John Zachary SANBORN, Stephen Charles BENZ, Charles Joseph VASKE
  • INTRALUMINAL MEDICAL IMAGING INTERFACE DEVICES AND SYSTEMS
    Publication number: 20220008036
    Abstract: An intraluminal medical imaging interface device includes an arm assembly comprising one or more longitudinal members and one or more joints coupled to the one or more longitudinal members, and a head assembly coupled to a distal portion of the arm assembly and comprising a proximal portion coupled to the distal portion of the arm assembly and a distal portion. The distal portion of the head assembly includes a mechanical coupling and an electrical coupling configured to separably connect to an intraluminal imaging catheter and to transmit electrical signals between a console and the intraluminal imaging catheter. The arm assembly is configured to couple to a surface to maintain the head assembly at a first position and an orientation with respect to a patient without continued support by an operator. Associated devices, systems, and methods are also provided.
    Type: Application
    Filed: April 25, 2019
    Publication date: January 13, 2022
    Inventors: Ashen GULSEN, Volker Barnhart VERSCHOOR, Andrew MITCHELL, Godefridus Antonius HARKS, Stephen Charles DAVIES, Dirk Jan Nelly VANANDEROYE
  • Hypoxic NK cells and methods therefor
    Patent number: 11221328
    Abstract: Detection of under-expression of selected genes in NK cells is used to confirm a hypoxic tumor microenvironment that is ordinarily suppressive with respect to ADCC and cytotoxic cell killing of NK cells. Most notably, while hypoxia is known to upregulate HIF-1? and genes under the control of HIF-1?, hypoxia in a tumor microenvironment led to under-expression of selected genes, including HIF-1?. Thus, gene expression analysis of certain genes on NK cells can be used to detect conditions in a tumor that would indicate use of haNK cells.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: January 11, 2022
    Assignee: NantCell, Inc.
    Inventors: Patrick Soon-Shiong, Shahrooz Rabizadeh, Kayvan Niazi, Stephen Charles Benz, Laurent H. Boissel, Hans Klingemann, Barry J. Simon
  • HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS
    Publication number: 20210402015
    Abstract: The present invention provides multi-armed high MW polymers containing hydrophilic groups and one or more functional agents, and methods of preparing such polymers.
    Type: Application
    Filed: August 23, 2021
    Publication date: December 30, 2021
    Inventors: Stephen A. CHARLES, Daniel Victor PERLROTH, Didier G. BENOIT, Lane A. CLIZBE, Wayne TO, Linda J. ZADIK, Jeanne M. PRATT
  • EVIDENCE BASED SELECTION OF PATIENTS FOR CLINICAL TRIALS USING HISTOPATHOLOGY
    Publication number: 20210381058
    Abstract: An immune gene expression signature and immune cell distribution in the tumor, in combination, can be used to infer an immune phenotype of the tumor, which further can be used to characterize the tumor, selecting an optimal immune therapy to the tumor, and predicting the treatment outcome of an immune therapy.
    Type: Application
    Filed: September 23, 2019
    Publication date: December 9, 2021
    Inventors: Christopher W. Szeto, Stephen Charles Benz
  • METHODS FOR TREATING LITHIUM-CONTAINING MATERIALS
    Publication number: 20210363648
    Abstract: The present disclosure relates to a method for extracting lithium from a lithium-containing material. For example, the method can comprise leaching a roasted lithium-containing material under conditions suitable to obtain an aqueous composition comprising a lithium compound such as lithium sulfate and/or lithium bisulfate. The aqueous composition comprising lithium sulfate and/or lithium bisulfate can optionally be used, for example, in a method for preparing lithium hydroxide comprising an electromembrane process. The roasted lithium-containing material can be prepared, for example by a method which uses an aqueous composition comprising optionally lithium sulfate and/or lithium bisulfate which can be obtained from a method for preparing lithium hydroxide comprising an electromembrane process such as a two-compartment monopolar or bipolar electrolysis process.
    Type: Application
    Filed: August 9, 2021
    Publication date: November 25, 2021
    Applicant: NEMASKA LITHIUM INC.
    Inventors: Jean-François MAGNAN, Guy BOURASSA, Nicolas LAROCHE, Gary PEARSE, Stephen Charles MACKIE, Mykolas GLADKOVAS, Peter SYMONS, J. David GENDERS, Geneviève CLAYTON, Pierre BOUCHARD
  • Healthcare object recognition, systems and methods
    Patent number: 11170882
    Abstract: Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 9, 2021
    Assignee: NANT HOLDINGS IP, LLC
    Inventors: Patrick Soon-Shiong, John Zachary Sanborn, Stephen Charles Benz, Charles Joseph Vaske
  • HETEROGENEOUS MEDIA EDITING ACROSS STORAGE PLATFORMS
    Publication number: 20210337042
    Abstract: Techniques for heterogenous video editing across storage platforms are disclosed, including: mapping a first mount in a local system to a first location in a first type of storage system, the first location including a first representation of the media object; mapping a second mount in the local system to a second location in a second type of file system, the second location including a second representation of the media object that is timecode-aligned with the first representation of the media object, the second representation being different from the first representation; and providing the first mount in the local system and the second mount in the local system to the media editing application, to enable the media editing application to switch between the first representation of the media object and the second representation of the media object via the local system.
    Type: Application
    Filed: April 27, 2021
    Publication date: October 28, 2021
    Inventors: Stephen Charles Tallamy, Andrew P. Liebman
  • Sequence arrangements and sequences for neoepitope presentation
    Patent number: 11154597
    Abstract: Systems and methods are presented that allow for selection of tumor neoepitopes that are then used to generate a recombinant polytope that is optimized for proper trafficking and processing. In preferred methods, the polytope is encoded in a viral expression system that is used as a therapeutic agent.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: October 26, 2021
    Assignees: NantCell, Inc., Nant Holdings IP, LLC, NantOmics, LLC
    Inventors: Kayvan Niazi, Andrew Nguyen, Shahrooz Rabizadeh, Patrick Soon-Shiong, Stephen Charles Benz
  • Dual PDGF/VEGF antagonists
    Patent number: 11155610
    Abstract: The invention provides a dual VEGF/PDGF antagonist comprising a VEGF antagonist linked to a PDGF antagonist. The VEGF antagonist is an antibody to a VEGF or VEGFR or is a VEGFR extracellular trap segment (i.e., a segment from the extracellular region of one or more VEGFR receptors that inhibits binding of at least one VEGFR to at least one VEGF). The PDGF antagonist is an antibody to a PDGF or PDGFR or is a PDGFR extracellular trap segment (i.e., segment from the extracellular region of one or more PDGFRs, which inhibits binding of at least one PDGFR and at least one PDGF). The dual antagonist is preferably conjugated to a half-life extending moiety, such as a HEMA-PC polymer. The dual antagonist is particularly useful for treating wet aged related macular degeneration.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 26, 2021
    Assignee: KODIAK SCIENCES INC.
    Inventors: Daniel Victor Perlroth, Stephen A. Charles, James Aggen, Didier Benoit, Wayne To, Lidia Mosyak, Laura Lin, Justin Cohen, Tetsuya Ishino, William Somers
  • Apparatus for testing a coefficient of friction and methods for same
    Patent number: 11150177
    Abstract: An apparatus for testing a coefficient of friction of an article is provided. The apparatus includes a base, a ramp, and an actuator. The ramp includes a first rail and a second rail that are spaced apart by a first distance. The first and second rails cooperate to define a first travel path for the article. The actuator is coupled with the base and is operably coupled with the ramp to facilitate selective pivoting of the ramp between a first angular position and a second angular position.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: October 19, 2021
    Assignee: The Gillette Company LLC
    Inventors: Hong Lu, Stephen Charles Witkus, Marilyn Jeanne Westgate, Janelle Marie Parechanian
  • Handle for a razor
    Patent number: 11130247
    Abstract: A handle for a razor cartridge is provided. The handle includes a body formed of a first material and defining a centerline, the body having a front end and a rear end, wherein the front end is coupled with the attachment end and wherein the body comprises a first shell and a second shell that are releasably coupled together. A cover layer formed of a second material at least partially overlies the body and surrounds entirely at least a portion of the body. The cover layer has a base surface having a plurality of projections extending therefrom. Each projection of the plurality of projections is interposed between a pair of immediately adjacent projections. Each projection defines a height where the height of each projection is greater than the height of one of the immediately adjacent projections and less than the height of the other immediately adjacent projection.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: September 28, 2021
    Assignee: The Gillette Company LLC
    Inventors: Hong Lu, Stephen Charles Witkus, Alexander Stephen Forti, Huibin Gong