Abstract: An annular seal cavity throat bushing includes an inner annular surface having a substantially latitudinal channel with the channel being provided with at least one orifice to allow fluid communication between the inside of the bushing and the outside of the bushing. The bushing is further provided with at least one groove extending substantially longitudinally from one end of the bushing to the channel. The groove has at least one tapered edge which increases the width of the groove along its length.

Abstract: A mechanical seal support system includes a pressure vessel for supplying barrier fluid to a mechanical seal, a device for determining the mass of the pressure vessel and a device for providing additional barrier fluid to the pressure vessel when a determination is made that the mass of the pressure vessel is below a predetermined level responsive to the device for determining mass of the pressure vessel.

Abstract: The invention provides a rotary or touch-sensitive control comprising a first rotatable and/or touch-sensitive body comprising means for displaying information relating to a parameter controlled by the first body, and a second rotatable and/or touch-sensitive body formed around the first rotatable body comprising means for displaying information relating to a parameter controlled by the second rotatable body.

Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

Abstract: The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Abstract: The disclosed subject matter provides N-hydroxymethanesulfonamide compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: The invention provides a method for the application of a treatment agent to a substrate, the method comprising the treatment of the pre-wetted substrate in an aqueous system comprising the solid particulate treatment agent in a closed container, the treatment being carried out at a ratio of liquor to substrate which does not exceed 2:1. Typically, the method is applied to the dyeing of textile fibres at liquor ratios of ?1:1 and is carried out in the absence of additives conventionally included for the sole purpose of promoting dye uptake by controlling electrical interactions or otherwise enhancing interactions between the substrate and the treatment agent. The invention also provides a method for the removal of surplus treatment agents following application of said treatment agents to a substrate, said method comprising not more than three wash-off treatments of said substrate with water following said application.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: A method of making a deep pile fabric that closely resembles natural sheepskin fleece. The method includes forming a length of pile fabric having fibers on one side and a scrim on an opposing side, where at least a portion of the fibers are natural wool fibers, and finishing the pile fabric as natural sheepskin by polishing the fiber side of the pile fabric, including guiding the length of pile fabric over at least two polishing rolls, where the two polishing rolls rotate in opposite directions.

Abstract: An organizer may send information relating to an event to participants via text messaging without having participants' texting numbers. Particularly, organizer may be associated with a texting number. Organizer sets event's start/end times, and provides email addresses for event invitees. Email requests invitees' texting numbers to participate in event. Texting numbers are stored, and encrypted respectively as identifiers. Organizer's message for participants is sent as text message to participants' texting numbers between event's start/end, and may be sent as if the message originated from organizer's texting number. When event ends, participants' texting numbers are deleted unless a participant participates in organizer's later ending event. In response to invitation to organizer's later event, a received participant's texting number may be encrypted as later identifier, and compared with identifier from earlier event.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Abstract: The present disclosure provides nitroxyl donating pharmaceutical compositions comprising N-substituted hydroxylamine derivatives. The compositions are highly efficacious in treating cardiovascular diseases (e.g., heart failure), have a suitable toxicological profile, and are sufficiently stable for intravenous or oral administration.

Abstract: A method of making a sheared wool, deep pile fabric that closely resembles natural sheepskin fleece that includes forming a length of wool pile fabric having natural wool fibers on one side and a scrim on an opposing side and finishing the wool pile fabric as natural shearling. The finishing process includes polishing the wool fiber side of the pile fabric by guiding the length of pile fabric over one or more heated first polishing rolls, applying a sheepskin conditioning solution to the wool fiber side of the pile fabric, further polishing the wool fiber side of the pile fabric by guiding the fabric a plurality of times over one or more second heated polishing rolls, and cutting the wool fibers to a designated length.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the polymeric particles comprise at least one antimicrobial agent. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one additional cleaning agent, and in this embodiment, it is preferred that the polymeric particles are mixed with the at least one additional cleaning agent. Preferably, the additional cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of polyester or nylon, most preferably in the form of beads.

Abstract: The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Abstract: A computer-implemented process includes: receiving into a computer memory a response to a generic question not specifically related to handwriting style; converting the response into one or more tags representing handwriting characteristics; selecting a typeface having a handwriting characteristic of one of the tags; receiving a text string to display into a computer memory; and displaying the text string by rendering glyphs from a font file containing glyphs for the selected typeface, after applying random variations to simulate human handwriting variation.

Abstract: An organizer may send information relating to an event to participants via text messaging without having participants' texting numbers. Particularly, organizer may be associated with a texting number. Organizer sets event's start/end times, and provides email addresses for event invitees. Email requests invitees' texting numbers to participate in event. Texting numbers are stored, and encrypted respectively as identifiers. Organizer's message for participants is sent as text message to participants' texting numbers between event's start/end, and may be sent as if the message originated from organizer's texting number. When event ends, participants' texting numbers are deleted unless a participant participates in organizer's later ending event. In response to invitation to organizer's later event, a received participant's texting number may be encrypted as later identifier, and compared with identifier from earlier event.