Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: The invention provides a method for the drying of a wet substrate, the method comprising treating the substrate with a solid particulate material at ambient or elevated temperature, the treatment being carried out in an apparatus comprising a drum comprising perforated side walls, wherein the drum comprising perforated side walls is rotated so as to facilitate increased mechanical action between the substrate and the particulate material. Preferably, the drum comprising perforated side walls has a capacity of between 5 and 50 liters for each kg of fabric in the load and is rotated at a speed which generates G forces in the range of from 0.05 to 0.99 G, and the method is carried out at a temperature of between 5° and 120° C. Preferably, the solid particulate material comprises a multiplicity of particles at a particle to fabric addition level of 0.1:1-10:1 by mass, wherein the particles comprise polymeric particles, non-polymeric particles, or mixtures of polymeric and non-polymeric particles.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the polymeric particles comprise at least one antimicrobial agent. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one additional cleaning agent and, in this embodiment, it is preferred that the polymeric particles are mixed with the at least one additional cleaning agent. Preferably, the additional cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fiber. Typically, the polymeric particles comprise particles of polyester or nylon, most preferably in the form of beads.

Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Abstract: A pressure regulation tracking valve for maintaining the pressure of a gas relative to that of a process fluid includes a device, responsive to change in the pressure of the process fluid, for changing the pressure of the gas by substantially the same amount. The valve further includes a device for accommodating a pressure transfer medium for transferring the pressure of the process fluid to the gas pressure changing device. As a result, contact between the process fluid and the gas pressure changing device is avoided.

Abstract: The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the formulation is free of organic solvents. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one cleaning material and, in this embodiment, it is preferred that the polymeric particles are coated with the at least one cleaning material. Preferably, the cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of nylon, most preferably in the form of nylon chips.

Abstract: The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the formulation is free of organic solvents. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one cleaning material and, in this embodiment, it is preferred that the polymeric particles are coated with the at least one cleaning material. Preferably, the cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fiber. Typically, the polymeric particles comprise particles of nylon, most preferably in the form of nylon chips.

Abstract: The invention is directed to wireless systems comprising one or more beacons that each emits a triggering data packet, and one or more smart media guides which upon receipt of a triggering packet, access the indicated track of digital content that has been preloaded into memory, and play that track through a user output interface. In some embodiments, each smart media guide transmits an SMG Identifier signal that can be received, stored and analyzed for purposes of understanding user behavior. In some embodiments, a transmitted content packet is transmitted by an exognenous source (such as a beacon or server-driven transceiver), received by a smart media guide, and stored for subsequent play. Beacon-based systems can be further used to trigger such things as alarms, lights, and various mechanisms. The invention has applications in such fields as tourism, marketing, demographic analysis, health care, pet care, safety and security.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the formulation is free of organic solvents. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one cleaning material and, in this embodiment, it is preferred that the polymeric particles are coated with the at least one cleaning material. Preferably, the cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fiber. Typically, the polymeric particles comprise particles of nylon, most preferably in the form of nylon chips.

Abstract: In one embodiment, a kit for making a personalized display includes a blank foldable to form a cavity according to score lines to form a display with a cavity, a print medium to receive a user selected-image and to adhere to the blank, and a bending wave generation unit attachable to a display element to receive a signal from a signal generator and produce bending waves within the display element that cause the display element to vibrate and generate audible acoustic waves in accordance with the signal. In another embodiment, a personalized display includes a blank with extensions folded to form a cavity, a print medium adhered to the blank and with a user-selected image printed via a digital printer, and a bending wave generation unit attached to a display element and positioned within the cavity.

Abstract: Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.

Abstract: Personalized wall clocks and kits for making the same are disclosed herein. A kit includes an image receiving medium to receive thereon a personalized digital printed image. The image receiving medium includes a digital ink/toner receiving layer or has a digital ink/toner receiving surface structure. The kit also includes a foldable material which includes a face portion having two opposed surfaces and at least four sides. One opposed surface is to receive the image receiving medium. The foldable material includes a foldable extension extending from each side of the face portion. Each foldable extension is to be folded no less than four times toward another of the opposed surfaces to form a three-dimensional supporting frame. The kit includes a hand-moving mechanism.

Abstract: An organizer may send information relating to an event to participants via text messaging without having participants' texting numbers. Particularly, organizer may be associated with a texting number. Organizer sets event's start/end times, and provides email addresses for event invitees. Email requests invitees' texting numbers to participate in event. Texting numbers are stored, and encrypted respectively as identifiers. Organizer's message for participants is sent as text message to participants' texting numbers between event's start/end, and may be sent as if the message originated from organizer's texting number. When event ends, participants' texting numbers are deleted unless a participant participates in organizer's later ending event. In response to invitation to organizer's later event, a received participant's texting number may be encrypted as later identifier, and compared with identifier from earlier event.

Abstract: Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.

Abstract: The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.