Patents by Inventor Stephen Alexander

Stephen Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5717047
    Abstract: The present invention relates to materials which comprise a surface having pendant groups of formula (I), in which the groups --B-- are the same or different, preferably the same, and each is --CH.sub.2 -- or --C(.dbd.O)--, preferably --CH.sub.2 --, R.sup.1 is hydrogen alkyl of 1 to 12, preferably 1 to 4 carbon atoms, or a group capable of bonding to, or bonded to, a ligand or R.sup.1 is a polymerisable, preferably ethylenically unsaturated, group and Z is a zwitterionic group. Usually both groups B are the same and are joined to identical groups so that the compound of formula (I) is achiral. New compounds are achiral glyceryl phosphatidyl choline analogues. Surfaces having the groups (I) at their surface have improved biocompatibility, and show reduced fibrinogen absorption, reduced platelet activation, reduced microorganism adhesion and are useful in the production of implants or prostheses, for extra-corporeal circuitry for body fluids, for treating membranes of various type, for contact lenses.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 10, 1998
    Assignee: Biocompatibles Limited
    Inventors: Jeremy Colin Russell, Stephen Alexander Charles, Richard Neil Templar Freeman, Judith Elizabeth Browne
  • Patent number: 5659084
    Abstract: Processes for preparing 2-substituted benzaldehydes of general formula (I), wherein: R.sub.1 is CH.sub.2 CH.sub.2 --(L.sub.1).sub.p --(CH.sub.2).sub.q --(L.sub.2).sub.r --CH.sub.2 --(T).sub.2 --Z; L.sub.1 and L.sub.2 are independently CH.sub.2 CH.sub.2, CH.dbd.CH or C.tbd.C; q is 0 to 8; p, r and s are independently 0 or 1; T is O, S, CH.sub.2, CH.dbd.CH, C.tbd.C; and Z is C.sub.1-4 alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl optionally mono substituted with CF.sub.3, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, methylthio, or trifluoromethylthio; and R.sub.2 and A are independently H, CF.sub.3, C.sub.1-4 alkyl, F, Cl, Br or I; are useful for preparing pharmaceutically active compounds.
    Type: Grant
    Filed: December 7, 1994
    Date of Patent: August 19, 1997
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Kerry Joseph Gombatz, Michael Anthony Forth, Jerome Francis Hayes, Michael Barry Mitchell, Stephen Alexander Smith
  • Patent number: 5645883
    Abstract: The present invention provides materials which comprise a surface having pendant zwitterionic groups Z comprising, as anion, a phosphate, sulphonate, carboxylate or phosphate-ester group or a phosphate ester group in which one or more of the ester oxygen atoms is replaced by --S--, --NH-- or by a valence bond and, as cation, an ammonium, phosphonium or sulphonium moiety, provided that where the anion is a phosphate-ester group or derivative thereof or sulphonate and the cation is a trialkyl quaternary ammonium group (the alkyl groups each containing from 1 to 4 carbon atoms) and the group linking the anion and cation moieties is an alkylene group, the alkylene group, contains at least 5, preferably at least 6, and more preferably at least 7, carbon atoms. The materials have improved biocompatibility for instance as evidenced by reduced protein deposition and reduced platelet activation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 8, 1997
    Assignee: Biocompatibles Limited
    Inventors: Jeremy Colin Russell, Richard Neil Templar Freeman, Stephen Alexander Charles
  • Patent number: 4625015
    Abstract: Antisera against synthetic peptides which neutralize influenza viruses of differing hemagglutinin subtypes, provide protection against infection by influenza virus and methods of preparing the same are disclosed.
    Type: Grant
    Filed: August 29, 1983
    Date of Patent: November 25, 1986
    Assignee: Scripps Clinic & Research Foundation
    Inventors: Nicola Green, Stephen Alexander
  • Patent number: 4005664
    Abstract: A pattern selection system for a sewing machine is provided by which operator influenced closure of a single electric switch can effect the selection of any one of a multiplicity of stitch patterns stored in an electronic memory in the sewing machine. Pattern selection can be effected either by repeated closure of the single switch, by a scanning system rendered effective by continuous closure of the single switch, or by a combination of both of these modes. This system is compatible with the provision of additional individual pattern selection switches for selecting special or frequently utilized individual patterns.
    Type: Grant
    Filed: September 17, 1975
    Date of Patent: February 1, 1977
    Assignee: The Singer Company
    Inventor: Stephen Alexander Garron
  • Patent number: 3987739
    Abstract: In a sewing machine in which any one of a variety of stitch patterns, each of which may have a different number of successive needle penetrations, may be produced repetitively, an operator influenced control is disclosed capable of limiting the operation of the sewing machine to the stitching of a single execution of any selected stitch pattern. After the stitching of the single pattern has been completed, further operation of the sewing machine is inhibited by suspension of needle reciprocation, needle jogging and work feed motion.
    Type: Grant
    Filed: August 7, 1975
    Date of Patent: October 26, 1976
    Assignee: The Singer Company
    Inventors: John Whilldin Wurst, Robert Conrad Hauf, Robert Louis Sedlatschek, Stephen Alexander Garron
  • Patent number: 3930403
    Abstract: A transfer compressor for transmitting pressure from one fluid to another comprising a cylinder, a piston slidable within the cylinder, a space within the cylinder at each end of the piston, means for admitting fluid to each of the spaces, a tell-tale rod mounted on one end of the piston passing slidably and sealingly through an end of the cylinder, one end of the piston presenting a different area presented by the other end of the piston to the fluid in contact with said other end whereby the pressure exerted on the fluid at one end of the piston may be different from the pressure existing in the fluid at the other end of the piston.
    Type: Grant
    Filed: July 23, 1974
    Date of Patent: January 6, 1976
    Assignee: Imperial Chemical Industries Limited
    Inventors: William Telford Cross, Stephen Alexander Gaydon, Andrew Gilchrist, Ernest Raymond Ellis