Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: A flexible insulation material may be configured to substantially reduce the amount of radiation transmitted therethrough by incorporating a reflective mat of high temperature fibers that withstand temperatures of at least 500° C. The flexible insulation may be stored and used over temperatures ranging from ?270° C. to 5000° C. The mat may have optical properties to produce a transmittance of no more than 5% over a range of temperature from 500° C. to 5000 vC. The mat may include high temperature fibers such as carbon and/or silicon carbide and these fibers may be coupled by a binder in a non-woven fabric. The flexible insulation material may be configured in the Flexible Thermal Protection System of a deployable aerodynamic decelerator or a Hypersonic Inflatable Aerodynamic Decelerator and may be durably flexible.

Abstract: A thermal protection systems of a deployable aerodynamic decelerators includes a high temperature flexible insulation that utilizes a Flexible Gas Barrier (FGB) configured on an outside layer of a Hypersonic Inflatable Aerodynamic Decelerator-Thermal Protective System (HIAD F-TPS). The high temperature flexible insulation includes high temperature fibers and frits that melt upon exposure to elevated temperatures to prevent advection through the thickness of the high temperature flexible insulation. A coating may also be configured on an outside surface of the high temperature flexible insulation to also prevent advection. The frits may be configured through the thickness with different melting temperatures.

Abstract: A flexible heat barrier is configured to absorb and deflect heat energy and utilizes a multilayer construction wherein each layer provides a specific purpose. An outer layer configured for exposure to a heat flux includes a coating having an intumescent component and an opacifier component. An inner layer includes a foil that may include a high emittance coating to more effectively reflect radiation. A middle layer includes an insulating fabric layer that may include oriented fibers that can effectively polarize radiation and may include a plurality of layers of oriented fibers that are configured at an offset angle to deflect and reduce radiation transmission through the middle layer. A flexible heat barrier may also include a flexible gas barrier that includes a phase change material, such as frits that melt at a predetermined temperature and flow into gaps to reduce the permeability and further block heat flux.

Abstract: The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to include antigen specific tolerance. The carrier particle is designed in order to trigger an immune tolerance effect. The invention is useful for treatment of immune related disorders such as autoimmune disease, transplant rejection and allergic reactions.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: An above-the-knee post-operative residual limb support device is described. The support device may be used shortly after amputation of a portion of a limb, such as a portion of a patient's leg (e.g., such as in an above-the knee (“AK”) amputation procedure). Such a support device may be referred to as an Immediate Post-Operative Prosthesis (“IPOP”).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions and methods for inducing antigen-specific tolerance in a subject. In one embodiment, the present invention provides a composition comprising an apoptotic body and an epitope of an antigen. Also provided herein are methods of preparing and administering the composition. The composition and methods provided herein can induce antigen-specific tolerance in a subject.

Abstract: The present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to induce antigen specific tolerance. The carrier particle is designed in order to trigger an immune tolerance effect. The invention is useful for treatment of immune related disorders such as autoimmune disease, transplant rejection and allergic reactions.

Abstract: This invention, in at least some embodiments, relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders and including for inducing tolerance to a specific antigen.