Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: This invention relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.

Abstract: A portable thermal protection system is provided for protecting equipment, facilities, and personnel in a region from a high intensity incident heat source. The system can be formed as a sleeping bag, a tent, a blanket, a sleeping bag, a vertical barrier, a curtain, a flexible rollup doorway, or a wrap. The system includes an outer textile layer first layer, an insulator second layer, and a non-porous film third layer which forms a gas barrier. Some embodiments include a fourth layer formed of a material to provide radiation protection. In some embodiments, the first and/or second layers are integrally formed with the materials that reflects radiation. The layers are joined together by high-temperature adhesives, stitching, needling, or tacking.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: A lightweight multilayer flame barrier includes alternating layers of a metal foil and an insulation layer to form a barrier layer. The metal foils may be configured on both the barrier surface and the interior surface. A barrier layer may be attached or coupled to a support layer. The lightweight multilayer flame barrier may be configured as a portable shelter that can be carried by fire service people and therefore may be lightweight and thin to enable compact storage and transport. The lightweight multilayer flame barrier may provide high convective exposure time in a thin lightweight composite.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: An above-the-knee post-operative residual limb support device is described. The support device may be used shortly after amputation of a portion of a limb, such as a portion of a patient's leg (e.g., such as in an above-the knee (“AK”) amputation procedure). Such a support device may be referred to as an Immediate Post-Operative Prosthesis (“IPOP”).

Abstract: Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by ThI, ThI 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1?, TNF-?, TGF-beta, IFN-?, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles. In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: This invention, in at least some embodiments, relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: This invention relates to a protein C1ORF32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.

Abstract: A fabric having resilient prominences on at least one surface is described for improved thermal protection, drag reduction and quick drying. Resilient prominences are bulges that extend outward from a fabric surface and trap some volume of air or other material therein. For example, a resilient prominence may be dome shaped and extend outward from the fabric plane. A resilient prominence is resilient in shape, whereby the resilient prominence may be compressed and then popped back into substantially the original shape. Reflective and/or absorptive materials may be configured on the surface of the fabric to provide camouflage from IR cameras. Reflective material may be configured on the fabric to reflect heat back to the wearer of a garment made with the fabric described.

Abstract: A portable thermal protection system is provided for protecting equipment, facilities, and personnel in a region from a high intensity incident heat source. The system can be formed as a sleeping bag, a tent, a blanket, a sleeping bag, a vertical barrier, a curtain, a flexible rollup doorway, or a wrap. The system includes an outer textile layer first layer, an insulator second layer, and a non-porous film third layer which forms a gas harrier. Some embodiments include a fourth layer formed of a material to provide radiation protection. In some embodiments, the first and/or second layers are integrally formed with the materials that reflects radiation. The layers are joined together by high-temperature adhesives, stitching, needling, or tacking.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

Abstract: Isolated cell surface receptors for B7-H4 have been identified based on function. B7-H4 receptor activation by B7-H4 on the dendritic cell, T follicular helper cell and germinal center B cell membrane stimulates inhibitory signaling in those leukocytes. B7-H4 receptor activation decreases production and/or secretion of proinflammatory cytokines, and promotes anti-inflammatory cytokine by mature DC and T cells. Modulators of B7-H4 receptor polypeptides and methods for their therapeutic use are also provided.

Abstract: Fusion proteins containing B7-II4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of a full-length B7-H4 polypeptide, including some or all of the extracellular domain of the B7-H4 polypeptide. Methods for using the fusion proteins to downregulate T cell activation and for the treatment of inflammatory and autoimmune diseases and disorders are also disclosed. The B7-H4 fusion proteins are useful for treating inflammation by inhibiting or reducing differentiation, proliferation, activity, and/or cytokine production and/or secretion by Th1, Th1 7, Th22, and/or other cells that secrete, or cause other cells to secrete, inflammatory molecules, including, but not limited to, IL-1?, TNF-?, TGF-beta, IFN-?, IL-17, IL-6, IL-23, IL-22, IL-21, and MMPs; or enhancing IL-IO secretion by Tregs, increasing the differentiation of Tregs, increasing the number of Tregs, or combinations thereof.

Abstract: The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).