Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Abstract: Compounds of formula (I) are inhibitors of p38 MAP kinase, and are therefore of utility in the treatment of, inter alia, inflammatory conditions including rheumatoid arthritis and COPD: formula (I) wherein: G is —N? or —CH?; D is an optionally substituted divalent mono- or bi-cyclic aryl or heteroaryl radical having 5-13 ring members; R6 is hydrogen or optionally substituted C1-C3 alkyl; P represents hydrogen and U represents a radical of formula (IA); or U represents hydrogen and P represents a radical of formula -A-(CH2)z—X1-L1-Y—NH—CHR1R2 wherein A represents an optionally substituted divalent mono- or bicyclic carbocyclic or heterocyclic radical having 5-13 ring members; z, Y, L1, and X1 are as defined in the specification; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular esterase enzymes to a carboxylic acid group; and R2 is the side chain of a natural or non-natural alpha amino acid.

Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Abstract: There is provided a support device (10) comprising a peripheral region (14), in the form of a closed loop and arranged to receive a receptacle, such as a synthetic plastics bag or refuse sack; a lid (12) being hinged to said peripheral region (14) and arranged to close over said region (14) when desired; at least one clip adapted to engage with the peripheral region (14) so as to retain the receptacle in a position; and a handle (16) for carrying the support device (10).

Abstract: Improved podcasts and techniques that facilitate their use are disclosed. The improved techniques can pertain to creating, publishing, hosting, accessing, subscribing, managing, transferring, and/or playing podcasts. According to one aspect, a client application can subscribe to podcasts and then automatically monitor the podcasts for updates to be downloaded. In the event that user interest in a podcast becomes inadequate, downloading of further updates can be restricted. According to another aspect, a podcast can be subscribed to through use of a portable subscription file. According to still another aspect, podcast feeds can be enhanced to include segment elements and other metadata.

Abstract: Compounds of formula (I) are inhibitors of P13 kinase activity, and useful in treatment of, inter alia, autoimmune, inflammatory and proliferative diseases: wherein: s is 0 or 1; U is hydrogen or halogen; X is —(C?O), an optionally substituted divalent phenylene, pyridinylene, pyrimidinylene, or pyrazinylene radical, or a bond; P is optionally substituted C1-C6 alkyl and Z is —(CH2)Z—X1-L1-NHCHR1R2; or Z is optionally substituted C1-C6 alkyl and P is —(CH2)Z—X1-L1-NHCHR1R2; R1 is a carboxylic acid group (—COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R2 is the side chain of a natural or non-natural alpha amino acid; X1 is (i) a bond; —NR4C(?O)NR5— or —NR4S(?O)2—; or except when X is —(C?O)— (ii) —C(?O)—, —S(?O)2—, or —S(?O)2NR4— wherein R4 and R5 are independently hydrogen or optionally substituted C1-C6 alkyl; and z and L1 are as defined in the specification.

Abstract: A connector assembly is disclosed for coupling a signal wire bundle from a controller console to a hand-operated catheter assembly. The connector includes a female connector component having a cylindrical cavity, wire fingers disposed within the cylindrical cavity, a guide peg disposed on a surface of the cylindrical cavity at a point proximate an opening of the cylindrical cavity, and a central pin disposed on a base surface at a closed end of the cylindrical cavity. The connector also includes a male connector component having a substantially cylindrical shape having a non-uniform transverse cross-section radius. The male connector component comprises a set of signal leads disposed along arcs of a cylindrical surface of the male connector, a slot defined within the male connector's surface is arranged to accept the guide peg of the female connector component and constrain the relative positions of the male connector and female connector during engagement.

Abstract: A connector assembly is disclosed for coupling a signal wire bundle from a controller console to a hand-operated catheter assembly. The connector includes a female connector component having a cylindrical cavity, wire fingers disposed within the cylindrical cavity, a guide peg disposed on a surface of the cylindrical cavity at a point proximate an opening of the cylindrical cavity, and a central pin disposed on a base surface at a closed end of the cylindrical cavity. The connector also includes a male connector component having a substantially cylindrical shape having a non-uniform transverse cross-section radius. The male connector component comprises a set of signal leads disposed along arcs of a cylindrical surface of the male connector, a slot defined within the male connector's surface is arranged to accept the guide peg of the female connector component and constrain the relative positions of the male connector and female connector during engagement.

Abstract: The invention concerns an aqueous delayed-gelation solution for use in hydrocarbon wells. According to the invention, the aqueous delayed-gelation solution a dissolved metal salt which, in use, hydrolyses to form a gel, wherein the solution contains suspended inorganic particles and the method comprises the steps of—providing the aqueous delayed-gelation solution, and—injecting the solution into the hydrocarbon well, whereby the suspended inorganic particles reduce or block the flow of the delayed-gelation solution to relatively low permeability formation zones thereby selectively placing the solution in a relatively high permeability formation zone.

Abstract: A tubular bracing assembly for a string instrument and the resulting string instrument. Resin reinforced fibers are shaped into the form of a tubular structure. The tubular structure decreases the weight and increases the stiffness of the structure. The result is a bracing system that has very light weight and varied stiffness properties to achieve desirable acoustic performance from the hollow body of an acoustic instrument.

Abstract: Improved podcasts and techniques that facilitate their use are disclosed. The improved techniques can pertain to creating, publishing, hosting, accessing, subscribing, managing, transferring, and/or playing podcasts. According to one aspect, a client application can subscribe to podcasts and then automatically monitor the podcasts for updates to be downloaded. In the event that user interest in a podcast becomes inadequate, downloading of further updates can be restricted. According to another aspect, a podcast can be subscribed to through use of a portable subscription file. According to still another aspect, podcast feeds can be enhanced to include segment elements and other metadata.

Abstract: A cam phaser assembly may include a drive plate assembly, a cavity plate, and a driven plate assembly. The drive plate assembly may include a drive plate and a first vane fixed for rotation with the drive plate. The cavity plate may be rotationally driven by the drive plate and may define first and second chambers. The first vane may extend into the first chamber. The driven plate assembly may be rotationally driven by the drive plate assembly and may include a driven plate and a second vane fixed for rotation with the driven plate that extends into the second chamber.

Abstract: A method, system, and computer program product for social based assistance in a source code control system are provided. The method includes selecting a segment of source code and parsing the selected segment of source code to identify one or more syntax terms. The method also includes searching source files for the one or more syntax terms to locate matching results, where the source files are managed by the source code control system. The method further includes scoring the matching results of the searching as a function of developer activity associated with the matching results. The method additionally includes identifying one or more developers with the highest degree of matching based on the scoring.

Abstract: Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.

Abstract: An aqueous oilfield treatment fluid containing a chelating agent and an HF source is described. This fluid is effective at dissolving siliceous materials such as clays and keeping the dissolved materials in solution. In particular it is effective at preventing re-precipitation of initially-dissolved silicon as silica and therefore reduces damage to sandstones with which it is contacted. Methods are given for using this fluid for sandstone matrix stimulation, removal of clay-containing drilling fluid components and filter cakes from wellbores, sandstone acid fracturing, and gravel pack and proppant pack cleaning.

Abstract: Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.

Abstract: A neck assembly for a string instrument and the resulting string instrument. Resin reinforced fibers are shaped into the form of an instrument neck around a tubular structure. The tubular structure creates conduits within the neck. The conduits interconnect, thereby forming a single resonance chamber. The presence of the conduits decreases the weight of the neck. The result is a synthetic instrument neck that has a weight and acoustical properties comparable to a traditional wooden neck. The synthetic neck may also contains at least one mounting plate that enables the synthetic neck to be connected to many preexisting instrument bodies and tuning key heads. The synthetic instrument neck can therefore be retroactively added to existing instruments without the need for alterations.