Abstract: Picornaviral 3C protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of picornaviral 3C proteases. These compounds, as well as pharmaceutical compositions that contain these compounds, are suitable for treating patients or hosts infected with one or more picornaviruses. Several novel methods and intermediates can be used to prepare the novel picornaviral 3C protease inhibitors of the present invention.

Abstract: Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.

Abstract: Quinazoline compounds which demonstrate antiproliferative activity, such as antitumor activity, processes of preparing these compounds, pharmaceutical compositions containing these compounds, and the use of these compounds. These compounds inhibit the growth and proliferation of the cells of higher organisms and microorganisms, such as bacteria, yeasts and fungi. Preferred quinazoline compounds are capable of inhibiting the enzyme thymidylate synthase. Effects derived from the inhibition of the enzyme thymidylate synthase include those discussed above.

Abstract: The present invention relates to methods of accelerated curing of condensation polymers or inducing cross-linking of polymers by a direct current corona or glow discharge applied to the polymer bulk. The methods permit low temperature removal of volatile components from a material without inducing a chemical reaction or local heating. These methods have been employed to prepare fracture-free polysiloxane films up to 100 .mu.m in thickness with curing time reduced by several orders of magnitude. A variety of metal ions, non-linear optical molecules or laser dyes may be incorporated in the films. The surface hydrophilicity of films may also be modified by this treatment. Additionally, an electrically conductive surface layer has been produced by incorporation of an appropriate dopant. Multilayered optical waveguide or lasing structures may be produced by this technique by successive deposition of spun films and curing.

Abstract: The present invention relates to a method of preparing glasses from metal alkoxides. Glasses are crack-free and prepared rapidly in a single step. Optically clear polysiloxane glasses as thin films may be prepared in a matter of minutes. A glow discharge curing method is disclosed which rapidly cures a wide range of condensation polymers, including polyamide resins and polymethylsiloxane glass films. Fracture-free films up to 100 .mu.m have been prepared. The glass films may be used as waveguides and to incorporate metals, donor-acceptor molecules and dyes. Stable, crack-free multiple-layered films may be prepared by the disclosed method which can be modified according to desired properties of the glasses.

Abstract: A series of alkanoarachidonic acids have been prepared as modulators of the arachidonic acid cascade to increase the production of biologically desirable compounds and minimize the production of biologically undesirable compounds. Examples of desirable compounds in this respect comprise postaglandins and thromboxanes whereas undesirable compounds comprise the mono- and polyhydroxyarachidonic acids and leukotrienes. The alkanoarachidonic acids and their intermediates are of the general formula: ##STR1## and at least one of X, Y, and Z is lower alkano and is hydrogen when not lower alkano; the esters and salts of the acids are also prepared. The acids, esters and salts may be used as anti-anaphylaxis or anti-thrombosis agents.