Abstract: Example shoe manufacturing methods and related computer readable medium for implementing a portion of said manufacturing methods are disclosed herein. In some examples, the method includes placing an upper member about an upper portion of a last, wherein the last is a form for the shoe. In addition, the method includes producing a lasting based on data relating to a foot of a user, and attaching the lasting to the upper member, wherein the lasting extends over a lower portion of the last. Further, the method includes molding a sole onto the lasting and the upper member, and removing the last from the upper member.

Abstract: A respiratory interface system for use in delivering a flow of a positive pressure breathing gas to an airway of a patient that includes a patient interface device with a tubing assembly structured to be disposed on the head of the patient, a mask having a sealing element structured to sealingly engage about the airway of the patient, and an adaptor. The adapter includes a flange portion that extends generally radially outward from a central aperture and a hollow male connector extending from the flange portion and coupled with a correspondingly-shaped female connector of the tubing assembly or the mask. The mask is coupled to the tubing assembly via the adaptor, and the tubing assembly, the mask, and the adapter define a pathway structured to conduct the flow of the positive pressure breathing gas to the airway of the patient.

Abstract: Systems and methods are provided for centralized validation of potential network calls, such as calls proposing database transactions, on a distributed system. The distributed system may include multiple systems that apply independent criteria for validating proposals, which criteria may not be available external to the individual systems. Moreover, the systems may lack an ability to validate proposals prior to submitting such proposals for commitment. A centralized network call parameter validation system as disclosed herein may validate potential network calls with high confidence by applying probability models of data pattern and hashing digit checksum to potential network call parameter values, which models are generated based on statistical analysis of historical network call values.

Abstract: A computer-implemented method, when executed by data processing hardware of a robot having an articulated arm and a base, causes data processing hardware to perform operations. The operations include determining a first location of a workspace of the articulated arm associated with a current base configuration of the base of the robot. The operations also include receiving a task request defining a task for the robot to perform outside of the workspace of the articulated arm at the first location. The operations also include generating base parameters associated with the task request. The operations further include instructing, using the generated base parameters, the base of the robot to move from the current base configuration to an anticipatory base configuration.

Abstract: An apparatus for forming a part is provided, which includes a die. The die includes a round orifice, a central mandrel disposed within the round orifice, and a plurality of bridges and a corresponding plurality of portholes between the bridges. The bridges and the portholes extending around the central mandrel. A spacing of the bridges around the mandrel is non-equiangular. The die allows a material to be extruded through the die to form a round, closed geometry tube from the material such that the round, closed geometry tube has non-equiangular welds after emerging from the die.

Abstract: An apparatus for shielding radiation emitted during a medical procedure. The apparatus includes a board positionable on top of a procedure table. The board extends laterally between a first board edge and a second board edge, and longitudinally between a third board edge and a fourth board edge. The board includes a plurality of apertures distributed along at least one of the board edges. At least one radiation shield is removably mountable to the board. The at least one radiation shield includes at least one peg engageable with any one of the apertures in the board. The apparatus can include a body shield assembly and/or an adjustable screen assembly.

Abstract: Various embodiments of an apparatus, method(s), system(s) and computer program product(s) described herein are directed to an Event Logging Engine. The Event Logging Engine logs event data identifying at least one of: (i) activity of one or more regulated user accounts within a virtual meeting during occurrence of the virtual meeting and (ii) activity of the one or more regulated user accounts with respect to a virtual meeting resource after occurrence of the virtual conference meeting. The Event Logging Engine inserts at least one regulated user account timestamp in the logged event data where each regulated user account is associated with a respective compliance policy. The Event Logging Engine receives a request from an external source for logged event data related to a particular regulated user account. The Event Logging Engine provides access to the logged event data related to one or more timestamps identifying the particular regulated user account.

Abstract: Methods and systems are provided for reducing ice formation in a charge air cooler. In one example, a method includes, operating a radiator fan of a vehicle in a first direction to cool an engine of the vehicle, and reversing a direction of rotation of the radiator fan to blow heated air towards a charge air cooler, the charge air cooler arranged proximate a radiator of the vehicle. Operating the radiator fan in a first direction may be based on the engagement of one or more gears of a transmission of the vehicle while operating the radiator fan in the reverse direction may be based on an engine temperature condition, one or more ambient weather conditions, and an engine idle condition.

Abstract: This invention relates to combination therapies for use in treating cancer, comprising a cyclin dependent kinase 2 (CDK2) inhibitor of Formula (I), as further described herein, and a cyclin dependent kinase 4/6 (CDK4/6) inhibitor, optionally in further combination with an additional anti-cancer agent=.

Abstract: Various embodiments of an apparatus, method(s), system(s) and computer program product(s) described herein are directed to an Event Logging Engine. The Event Logging Engine logs event data identifying at least one of: (i) activity of one or more regulated user accounts within a virtual meeting during occurrence of the virtual meeting and (ii) activity of the one or more regulated user accounts with respect to a virtual meeting resource after occurrence of the virtual conference meeting. The Event Logging Engine inserts at least one regulated user account timestamp in the logged event data where each regulated user account is associated with a respective compliance policy. The Event Logging Engine receives a request from an external source for logged event data related to a particular regulated user account. The Event Logging Engine provides access to the logged event data related to one or more timestamps identifying the particular regulated user account.

Abstract: Example shoe manufacturing methods and related computer readable medium for implementing a portion of said manufacturing methods are disclosed herein. In some examples, the method includes producing a lower portion of a last based on data relating to a foot of a user. In addition, the method includes placing an upper member about the last such that a lasting of the upper member extends over the lower portion of the last. Further, the method includes producing a midsole element based on the data relating to the foot of the user, and attaching the midsole element to the upper member such that the lasting is disposed between the lower portion of the last and the midsole element.

Abstract: A retention assembly is for a patient interface device. The patient interface device includes a cushion member structured to engage a face of a patient. The retention assembly includes: a retention member structured to be coupled to the cushion member; a headgear member; a first interconnect member removably coupled to the retention member; and a second interconnect member removably coupled to the headgear member. The second interconnect member is removably coupled to the first interconnect member in order to couple the headgear member to the retention member.

Abstract: The invention provides a method for treating a disease or disorder, and preferably cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a CDK2 inhibitor, and a therapeutically effective amount of a CDK4/6 inhibitor, wherein the CDK4/6 inhibitor prevents rebound phosphorylation mediated by CDK4 and/or CDK6 in response to the inhibition of CDK2.

Abstract: An engine system includes a charge-air cooler, a separator for separating water from an airflow, and an engine. The separator causes an airflow from the charge-air cooler to strike one or more partitions and change directions via a serpentine path such that water is separated out of the airflow before the airflow reaches the engine.

Abstract: Methods and systems are provided for reducing ice formation in a charge air cooler. In one example, a method includes, operating a radiator fan of a vehicle in a first direction to cool an engine of the vehicle, and reversing a direction of rotation of the radiator fan to blow heated air towards a charge air cooler, the charge air cooler arranged proximate a radiator of the vehicle. Operating the radiator fan in a first direction may be based on the engagement of one or more gears of a transmission of the vehicle while operating the radiator fan in the reverse direction may be based on an engine temperature condition, one or more ambient weather conditions, and an engine idle condition.

Abstract: A security threat candidate (STC) detector examines a set of activity log records representing access requests directed to data artifacts by various entities of an organization. In a first threat analysis, the STC detector determines that an activity log record indicates a use of an access path which is not present in a database of legitimate access paths for an entity. In a second threat analysis, the STC detector determines whether the behavior of the entity matches a stored suspect behavior pattern template. Results of the first and/or second analysis are transmitted to a selected security management component of the organization.

Abstract: An engine system includes a charge-air cooler, a separator for separating water from an airflow, and an engine. The separator causes an airflow from the charge-air cooler to strike one or more partitions and change directions via a serpentine path such that water is separated out of the airflow before the airflow reaches the engine.

Abstract: A computer-implemented method executed by data processing hardware of a robot causes the data processing hardware to receive sensor data associated with a door. The data processing hardware determines, using the sensor data, door properties of the door. The door properties can include a door width, a grasp search ray, a grasp type, a swing direction, or a door handedness. The data processing hardware generates a door movement operation based on the door properties. The data processing hardware can execute the door movement operation to move the door. The door movement operation can include pushing the door, pulling the door, hooking a frame of the door, or blocking the door. The data processing hardware can utilize the door movement operation to enable a robot to traverse a door without human intervention.

Abstract: Methods and systems are provided for maintaining a temperature of exhaust gases of an engine within a temperature range at which catalytic conversion is most efficient. In one example, a method for controlling a temperature of exhaust gases entering a Selective Catalytic Reduction (SCR) system for an engine comprises delivering pressurized air into the exhaust gases upstream of the SCR system, the pressurized air cooled by an air cooler; and adjusting a degree of pressurization by adjusting operation of a turbocharger pressurizing the pressurized air. In one embodiment, the air cooler may be a charge air cooler of a primary turbocharger of the engine, which may flow pressurized air both to the engine and to the SCR system. In other embodiments, the air may be pressurized by an air pump or a secondary dilution turbocharger, and cooled by a secondary charge air cooler.

Abstract: This invention relates to a method for treating cancer by administering a CDK4/6 inhibitor or CDK2/4/6 inhibitor in combination with a 4-1BB agonist and/or an OX40 agonist to a subject in need thereof.