Patents by Inventor Stephen Gitu Machatha

Stephen Gitu Machatha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methotrexate treatment methods
    Patent number: 11911385
    Abstract: The present disclosure provides compositions of methotrexate for ocular administration, including intravitreal administration, and use of the formulations for treating proliferative vitreoretinopathy (PVR), uveitis, macular edema, and uveitic macular edema.
    Type: Grant
    Filed: December 14, 2022
    Date of Patent: February 27, 2024
    Assignee: ALDEYRA THERAPEUTICS, INC.
    Inventors: Stephen Gitu Machatha, Dean Eliott, Tomasz Stryjewski
  • Ophthalmic formulations and uses thereof
    Patent number: 11786518
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating a disease or disorder such as allergic conjunctivitis.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: October 17, 2023
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: David Clark, Susan Macdonald, Stephen Gitu Machatha, Lise Lund Kjems
  • DRY EYE DISEASE BIOMARKERS AND THEIR USE FOR TREATMENT
    Publication number: 20230228744
    Abstract: The present invention relates to use of biomarkers of dry eye disease, and use of the biomarkers for selection of subjects for treatment and treatment of dry eye disease.
    Type: Application
    Filed: June 4, 2021
    Publication date: July 20, 2023
    Inventors: Todd BRADY, Stephen Gitu MACHATHA, Adam BROCKMAN
  • QUINOLINE COMPOUNDS FOR TREATING LUNG, LIVER, AND KIDNEY DISEASES, DISORDERS, OR CONDITIONS
    Publication number: 20230149383
    Abstract: The present invention relates to the use of a quinoline compound, or a pharmaceutically acceptable salt thereof, for treatment of a respiratory disease, disorder, or condition selected from chronic cough, pneumonia, and pulmonary sepsis, or an organ L disease, disorder, or condition selected from alcohol induced hepatitis, minimal change disease, and focal segmental glomerulosclerosis.
    Type: Application
    Filed: April 13, 2021
    Publication date: May 18, 2023
    Inventors: Todd BRADY, Adam BROCKMAN, Stephen Gitu MACHATHA
  • QUINOLINE COMPOUNDS FOR TREATING RESPIRATORY DISORDERS AND VIRAL INFECTIONS
    Publication number: 20230131929
    Abstract: The present invention relates to the use of a quinoline compound, or a pharmaceutically acceptable salt thereof, for treatment of ARDS, viral infections, and other diseases, disorders, and conditions such as those described herein.
    Type: Application
    Filed: March 24, 2021
    Publication date: April 27, 2023
    Inventors: Todd BRADY, Adam BROCKMAN, Stephen Gitu MACHATHA
  • OPHTHALMIC FORMULATIONS OF METHOTREXATE
    Publication number: 20230017743
    Abstract: The present disclosure provides formulations of methotrexate for ocular administration, including intravitreal administration, and use of the formulations for treating proliferative vitreoretinopathy (PVR), intraocular lymphoma (e.g., PVRL), and intraocular inflammation.
    Type: Application
    Filed: September 15, 2022
    Publication date: January 19, 2023
    Inventors: Dean ELIOTT, Stephen Gitu MACHATHA, Pramod SARPOTDAR, Tomasz STRYJEWSKI
  • OPHTHALMIC FORMULATIONS OF METHOTREXATE
    Publication number: 20230018197
    Abstract: The present disclosure provides formulations of methotrexate for ocular administration, including intravitreal administration, and use of the formulations for treating proliferative vitreoretinopathy (PVR), intraocular lymphoma (e.g., PVRL), and intraocular inflammation.
    Type: Application
    Filed: September 15, 2022
    Publication date: January 19, 2023
    Inventors: Dean ELIOTT, Stephen Gitu MACHATHA, Pramod SARPOTDAR, Tomasz STRYJEWSKI
  • OPHTHALMIC FORMULATIONS OF METHOTREXATE
    Publication number: 20220370460
    Abstract: The present disclosure provides formulations of methotrexate for ocular administration, including intravitreal administration, and use of the formulations for treating proliferative vitreoretinopathy (PVR), intraocular lymphoma (e.g., PVRL), and intraocular inflammation.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 24, 2022
    Inventors: Dean ELIOTT, Stephen Gitu MACHATHA, Pramod SARPOTDAR, Tomasz STRYJEWSKI
  • TREATMENT OF DRY EYE DISEASE
    Publication number: 20220211691
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Application
    Filed: March 15, 2022
    Publication date: July 7, 2022
    Inventors: Todd Brady, Stephen Gitu Machatha
  • FORMULATIONS FOR TREATMENT OF DRY EYE DISEASE
    Publication number: 20220133629
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Application
    Filed: October 12, 2021
    Publication date: May 5, 2022
    Inventors: David CLARK, Todd BRADY, Susan MACDONALD, Stephen Gitu MACHATHA
  • INJECTABLE FORMULATIONS
    Publication number: 20220133697
    Abstract: The present disclosure relates to therapeutic compounds and formulations for treating, reducing the risk of, or for preventing a disease, disorder, or condition characterized by the presence of toxic aldehydes.
    Type: Application
    Filed: December 5, 2019
    Publication date: May 5, 2022
    Inventors: Stephen Gitu MACHATHA, Susan MACDONALD
  • Polymorphic compounds and uses thereof
    Patent number: 11312692
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: April 26, 2022
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: Stephen Gitu Machatha, Jonathan J. Loughrey, Hannah Ruth McLachlan, Gregor Sneddon
  • PROCESS FOR PREPARATION OF ALDEHYDE SCAVENGER AND INTERMEDIATES
    Publication number: 20220089542
    Abstract: The present invention relates to methods for synthesizing compounds, and to intermediates thereto, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis.
    Type: Application
    Filed: May 2, 2020
    Publication date: March 24, 2022
    Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY
  • POLYMORPHIC COMPOUNDS AND USES THEREOF
    Publication number: 20220017475
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.
    Type: Application
    Filed: August 6, 2019
    Publication date: January 20, 2022
    Inventors: Stephen Gitu MACHATHA, Jonathan J. LOUGHREY, Hannah Ruth MCLACHLAN, Gregor SNEDDON
  • PHARMACEUTICAL FORMULATIONS AND USES THEREOF
    Publication number: 20210393527
    Abstract: The present invention relates to pharmaceutical compositions and unit dosage forms comprising a quinoline compound, or a pharmaceutically acceptable salt thereof, which are useful for treatment of a disease, disorder, or condition such as inflammatory diseases, respiratory diseases, organ diseases, viral infections, and sequelae and associated conditions such as acute respiratory distress syndrome.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 23, 2021
    Inventors: Todd BRADY, Adam BROCKMAN, Stephen Gitu MACHATHA
  • POLYMORPHIC COMPOUNDS AND USES THEREOF
    Publication number: 20210393612
    Abstract: The present invention relates to free-base and salt forms, and compositions thereof of small molecule therapeutics acting as a scavenger for toxic aldehydes. The present invention further relates to use of the free-base and salt forms, and compositions thereof for treating diseases, disorders, or conditions in which aldehyde toxicity is implicated in their pathogenesis.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 23, 2021
    Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY, Steven KRAUSERT, Jonathan James LOUGHREY, Hannah Ruth MCLACHLAN, Gregor SNEDDON
  • Formulations for treatment of dry eye disease
    Patent number: 11197821
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: December 14, 2021
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: David Clark, Todd Brady, Susan Macdonald, Stephen Gitu Machatha
  • CONTACT LENS SOLUTIONS AND KITS
    Publication number: 20210317385
    Abstract: The present disclosure relates to contact lens solution comprising cyclodextrin, ophthalmic solutions comprising cy-clodextrin for treating disorders or conditions associated with wearing of contact lenses, methods of treating such disorders or conditions using the ophthalmic cyclodextrin solutions, and kits and combination products thereof.
    Type: Application
    Filed: October 2, 2019
    Publication date: October 14, 2021
    Inventors: Susan MACDONALD, Stephen Gitu MACHATHA
  • OPHTHALMIC FORMULATIONS AND USES THEREOF
    Publication number: 20200323841
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating a disease or disorder such as allergic conjunctivitis.
    Type: Application
    Filed: March 20, 2020
    Publication date: October 15, 2020
    Inventors: David CLARK, Susan MACDONALD, Stephen Gitu MACHATHA, Lise Lund KJEMS
  • FORMULATIONS FOR TREATMENT OF DRY EYE DISEASE
    Publication number: 20200121591
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Application
    Filed: September 25, 2019
    Publication date: April 23, 2020
    Inventors: David Clark, Todd Brady, Susan Macdonald, Stephen Gitu Machatha