Patents by Inventor Stephen Gitu Machatha

Stephen Gitu Machatha has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11312692
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: April 26, 2022
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: Stephen Gitu Machatha, Jonathan J. Loughrey, Hannah Ruth McLachlan, Gregor Sneddon
  • Publication number: 20220089542
    Abstract: The present invention relates to methods for synthesizing compounds, and to intermediates thereto, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis.
    Type: Application
    Filed: May 2, 2020
    Publication date: March 24, 2022
    Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY
  • Publication number: 20220017475
    Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.
    Type: Application
    Filed: August 6, 2019
    Publication date: January 20, 2022
    Inventors: Stephen Gitu MACHATHA, Jonathan J. LOUGHREY, Hannah Ruth MCLACHLAN, Gregor SNEDDON
  • Publication number: 20210393527
    Abstract: The present invention relates to pharmaceutical compositions and unit dosage forms comprising a quinoline compound, or a pharmaceutically acceptable salt thereof, which are useful for treatment of a disease, disorder, or condition such as inflammatory diseases, respiratory diseases, organ diseases, viral infections, and sequelae and associated conditions such as acute respiratory distress syndrome.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 23, 2021
    Inventors: Todd BRADY, Adam BROCKMAN, Stephen Gitu MACHATHA
  • Publication number: 20210393612
    Abstract: The present invention relates to free-base and salt forms, and compositions thereof of small molecule therapeutics acting as a scavenger for toxic aldehydes. The present invention further relates to use of the free-base and salt forms, and compositions thereof for treating diseases, disorders, or conditions in which aldehyde toxicity is implicated in their pathogenesis.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 23, 2021
    Inventors: Stephen Gitu MACHATHA, Charles MONTGOMERY, Steven KRAUSERT, Jonathan James LOUGHREY, Hannah Ruth MCLACHLAN, Gregor SNEDDON
  • Patent number: 11197821
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: December 14, 2021
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: David Clark, Todd Brady, Susan Macdonald, Stephen Gitu Machatha
  • Publication number: 20210317385
    Abstract: The present disclosure relates to contact lens solution comprising cyclodextrin, ophthalmic solutions comprising cy-clodextrin for treating disorders or conditions associated with wearing of contact lenses, methods of treating such disorders or conditions using the ophthalmic cyclodextrin solutions, and kits and combination products thereof.
    Type: Application
    Filed: October 2, 2019
    Publication date: October 14, 2021
    Inventors: Susan MACDONALD, Stephen Gitu MACHATHA
  • Publication number: 20200323841
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating a disease or disorder such as allergic conjunctivitis.
    Type: Application
    Filed: March 20, 2020
    Publication date: October 15, 2020
    Inventors: David CLARK, Susan MACDONALD, Stephen Gitu MACHATHA, Lise Lund KJEMS
  • Publication number: 20200121591
    Abstract: The present invention provides a reproxalap ophthalmic solution, and methods of using the same for treating dry eye disease.
    Type: Application
    Filed: September 25, 2019
    Publication date: April 23, 2020
    Inventors: David Clark, Todd Brady, Susan Macdonald, Stephen Gitu Machatha
  • Publication number: 20200062712
    Abstract: The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
    Type: Application
    Filed: April 4, 2019
    Publication date: February 27, 2020
    Inventors: Stephen Gitu Machatha, Scott Young
  • Publication number: 20200038392
    Abstract: The present invention provides topical, e.g., dermal, pharmaceutical compositions comprising an active agent. The present invention further provides methods of preparing such compositions and methods of treating a disease, disorder, or condition, such as a skin disease, using the same.
    Type: Application
    Filed: August 2, 2019
    Publication date: February 6, 2020
    Inventors: Todd Brady, David Clark, Susan Macdonald, Stephen Gitu Machatha, Cameron Robert Stevenson, Charles Rodney Greenaway Evans
  • Patent number: 10426790
    Abstract: The present disclosure provides methods of treating eye allergies and allergic conjunctivitis with cyclodextrin. Ophthalmic compositions of cyclodextrin for topical administration are also provided.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: October 1, 2019
    Assignee: Aldeyra Therapeutics, Inc.
    Inventors: Scott Young, Todd Brady, Stephen Gitu Machatha, David Clark, Susan Macdonald
  • Publication number: 20180050989
    Abstract: The present invention provides compounds and methods for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.
    Type: Application
    Filed: August 22, 2017
    Publication date: February 22, 2018
    Inventors: Stephen Gitu Machatha, Scott Young
  • Publication number: 20170266220
    Abstract: The present disclosure provides methods of treating eye allergies and allergic conjunctivitis with cyclodextrin. Ophthalmic compositions of cyclodextrin for topical administration are also provided.
    Type: Application
    Filed: February 28, 2017
    Publication date: September 21, 2017
    Inventors: Scott Young, Todd Brady, Stephen Gitu Machatha, David Clark, Susan Macdonald