Patents by Inventor Stephen J. Chudzik

Stephen J. Chudzik has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8871819
    Abstract: Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: October 28, 2014
    Assignee: SurModics, Inc.
    Inventors: Emily R. R. Meyering, Stephen J. Chudzik
  • Patent number: 8535700
    Abstract: Pro-fibrotic coatings for medical articles are described that include a pro-fibrotic polymer such as collagen. The pro-fibrotic coatings can also include a thromboresistant polymer. The coatings can be formed by activation of photoreactive groups pendent or independent of the coating materials.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: September 17, 2013
    Assignee: Surmodics, Inc.
    Inventors: Joseph A. Chinn, Stephen J. Chudzik, Sean M. Stucke
  • Patent number: 8512736
    Abstract: Biodegradable coatings and articles that include natural biodegradable polysaccharides are described. The coatings and articles are formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 20, 2013
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
  • Patent number: 8377461
    Abstract: The invention provides medical articles that include more than one biocompatibility-promoting function. In one aspect, the invention provides a medical articles that include a polymeric matrix including more than one biocompatible agent, wherein each biocompatible agent is provided at a distinct portion of the medical article surface. Methods of making medical articles, as well as methods of using the same, are also described.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 19, 2013
    Assignee: Surmodics, Inc.
    Inventors: Joseph A. Chinn, Sean M. Stucke, Stephen J. Chudzik
  • Patent number: 8242179
    Abstract: The invention provides a system and method for treating an orthopedic condition using a hydrogel-forming composition, which forms a hydrogel in situ at a target location and at least bio-mechanically treats the condition. The invention also provides a hydrogel forming composition designed to form a hydrogel with desirable biocompatible and biomechanical properties. In some aspects the hydrogel is formed in a water-permeable casing, which is delivered to an orthopedic joint in a minimally invasive manner. In particular, the system and method can be used for intervertebral disc replacement or repair.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc.
    Inventor: Stephen J. Chudzik
  • Patent number: 8241655
    Abstract: Biodegradable coatings that include natural biodegradable polysaccharides are described. The coating is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups.
    Type: Grant
    Filed: May 12, 2005
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Joseph A. Chinn, Dale G. Swan, Michael J. Burkstrand
  • Patent number: 8241656
    Abstract: Medical articles having a body member including natural biodegradable polysaccharides are described. The body member is formed from a plurality of natural biodegradable polysaccharides having pendent coupling groups. The body member can also include a bioactive agent which can be released to provide a therapeutic effect to a patient.
    Type: Grant
    Filed: November 11, 2005
    Date of Patent: August 14, 2012
    Assignee: Surmodics, Inc
    Inventors: Stephen J. Chudzik, Dale G. Swan, Michael J. Burkstrand
  • Patent number: 8202833
    Abstract: The present invention provides method and materials for forming a polymeric matrix having improved biocompatible properties. A polymerization accelerator is provided that includes an N-vinyl group and a biocompatible functional group. The polymerization accelerator is particularly useful for the polymerization of macromers, which can be used to form biocompatible polymeric coatings on the surface of biological materials, such as cells and tissue.
    Type: Grant
    Filed: November 26, 2003
    Date of Patent: June 19, 2012
    Assignee: Surmodics, Inc.
    Inventors: Dale G. Swan, Stephen J. Chudzik, Ronald F. Ofstead
  • Patent number: 8143043
    Abstract: Positively-charged initiator polymers having a polymerization initiator group and a cationic portion are provided. The initiator polymers can be used with a polymerizable material for the formation of a polymeric matrix on a surface. The initiator polymers are particularly useful for cell encapsulation using macromers.
    Type: Grant
    Filed: April 2, 2009
    Date of Patent: March 27, 2012
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Ronald F. Ofstead, Dale G. Swan
  • Publication number: 20120010707
    Abstract: Polymeric coatings that include coupled biomolecules are formed on the surface of articles, such as medical devices. A coated layer that includes a synthetic polymer including a reactive group is formed on a surface and then a biomolecule is attached to the reactive group. The synthetic polymer can be an acrylate polymer or an amine-containing polymer having pendent photoreactive groups.
    Type: Application
    Filed: September 23, 2011
    Publication date: January 12, 2012
    Inventors: Toni M. Heyer, Dale G. Swan, Stephen J. Chudzik, Joseph A. Chinn, Ralph A. Chappa
  • Publication number: 20120004339
    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
    Type: Application
    Filed: September 16, 2011
    Publication date: January 5, 2012
    Applicant: SURMODICS, INC.
    Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
  • Publication number: 20110275725
    Abstract: Embodiments of the invention include glycerol esters and use of the same for active agent delivery systems and methods. In an embodiment, the invention includes an active agent eluting device including a glycerol ester, an active agent dispersed within the glycerol ester, the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. In an embodiment, the invention includes a composition including a glycerol ester; an active agent dispersed within the glycerol ester; the active agent eluting device configured to elute the active agent from the glycerol ester in response to degradation of the glycerol ester. Other embodiments are also included herein.
    Type: Application
    Filed: May 10, 2011
    Publication date: November 10, 2011
    Inventors: Emily R.R. Meyering, Stephen J. Chudzik
  • Patent number: 8039524
    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: October 18, 2011
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Pam Read, legal representative, Dale G. Swan, Peter H. Duquette
  • Patent number: 7968614
    Abstract: The invention provides compositions that include macromers and visible light-activated polymerization initiators, and methods for forming a matrix using these compositions in conjunction with a light source that emits light primarily in the visible light spectrum.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: June 28, 2011
    Assignee: Surmodics, Inc.
    Inventors: Stephen J. Chudzik, Michael J. Burkstrand
  • Patent number: 7919111
    Abstract: Medical implants formed of hydrophobic derivatives of natural biodegradable polysaccharides and that include bioactive agent are described. The implants demonstrate desirable bioactive agent release profiles and can be prepared to have high drug loading. The implants can be used to treat medical conditions, such as those requiring prolonged administration of the bioactive agent at a target location in the body.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: April 5, 2011
    Assignee: SurModics, Inc.
    Inventors: Stephen J. Chudzik, Signe R. Erickson, Jeffrey J. Missling
  • Publication number: 20110040057
    Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic ? cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.
    Type: Application
    Filed: October 25, 2010
    Publication date: February 17, 2011
    Inventors: Stephen J. Chudzik, Dale G. Swan
  • Publication number: 20100316687
    Abstract: Hydrophobic ?(1?4)glucopyranose polymers with enhanced degradation properties are described. Between the ?(1?4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
    Type: Application
    Filed: June 11, 2010
    Publication date: December 16, 2010
    Inventors: Dale G. Swan, Emily R. Rolfes Meyering, Aleksey V. Kurdyumov, Stephen J. Chudzik, Pamela J. Reed
  • Patent number: 7820158
    Abstract: Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic ? cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: October 26, 2010
    Assignee: SurModics, Inc.
    Inventors: Stephen J. Chudzik, Dale G. Swan
  • Publication number: 20100240789
    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
    Type: Application
    Filed: May 20, 2010
    Publication date: September 23, 2010
    Applicant: SurModics, Inc.
    Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
  • Patent number: 7794751
    Abstract: A coating composition, in both its uncrosslinked and crosslinked forms, for use in delivering a medicament from the surface of a medical device positioned in vivo. Once crosslinked, the coating composition provides a gel matrix adapted to contain the medicament in a form that permits the medicament to be released from the matrix in a prolonged, controlled, predictable and effective manner in vivo. A composition includes a polyether monomer, such as an alkoxy poly(alkylene glycol), a carboxylic acid-containing monomer, such as (meth)acrylic acid, a photoderivatized monomer, and a hydrophilic monomer such as acrylamide.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: September 14, 2010
    Assignee: SurModics, Inc.
    Inventors: Stephen J. Chudzik, Terrence P. Everson, Richard A. Amos