Patents by Inventor Stephen J. Klaus

Stephen J. Klaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170216248
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and far treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: April 13, 2017
    Publication date: August 3, 2017
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson, Todd W. Seeley, Ingrid Langsetmo Parobok
  • Publication number: 20150246886
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: November 19, 2013
    Publication date: September 3, 2015
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson, Todd W. Seeley, Ingrid Langsetmo Parobok
  • Publication number: 20150080425
    Abstract: The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase.
    Type: Application
    Filed: July 16, 2014
    Publication date: March 19, 2015
    Applicant: FibroGen, Inc.
    Inventors: STEPHEN J. KLAUS, Al Y. Lin, Thomas B. Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Lee A. Flippin, Michael P. Arend, Alex Melekhov
  • Publication number: 20150012423
    Abstract: A computer system for validating an account to be used in an electronic payment includes a processor coupled to a memory device. The computer system is programmed to receive an account validation web request from a bill payment originator. The account validation web request includes account details. The computer system is further programmed to process the account validation web request to parse the account details, validate the account details associated with the account validation web request using at least one validation rule, and transmit an account validation web response to the bill payment originator.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 8, 2015
    Inventors: Amy Christine Milam, Stephen J. Klaus, Allen Russell Thompson, Richard G. Ampleman
  • Patent number: 8865173
    Abstract: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: October 21, 2014
    Assignee: Fibrogen, Inc.
    Inventors: Suzanne M. Spong, Thomas B. Neff, Stephen J. Klaus
  • Publication number: 20140279464
    Abstract: At a computing device, optionally located in communication with an intermediate node in an electronic bill payment system, access is obtained to a data structure including a plurality of valid customer account numbers for customers of a biller that utilizes or desires to utilize the electronic bill presentment and payment system. With the computing device, each character of each of said valid customer account numbers is replaced with a wild card in accordance with a normalization scheme, to obtain a plurality of normalized valid customer account numbers. At least one pattern of said wild cards in said plurality of normalized valid customer account numbers is designated as a recommended account mask.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: MasterCard International Incorporated
    Inventors: Amy C. Milam, Stephen J. Klaus, Mirza S. Zafar
  • Publication number: 20140142136
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: November 19, 2013
    Publication date: May 22, 2014
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Robert C. Stephenson
  • Patent number: 8728468
    Abstract: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing melanoma tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF).
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: May 20, 2014
    Assignee: FibroGen, Inc.
    Inventors: Suzanne M. Spong, Thomas B. Neff, Stephen J. Klaus
  • Patent number: 8629131
    Abstract: The present invention relates to methods for increasing iron absorption in a subject by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: January 14, 2014
    Assignee: Fibrogen, Inc.
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Patent number: 8614204
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: December 24, 2013
    Assignee: Fibrogen, Inc.
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Patent number: 8609646
    Abstract: The present invention relates to methods and compounds for decreasing the expression of hepcidin, a protein associated with regulation of iron metabolism.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 17, 2013
    Assignee: Fibrogen, Inc.
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Patent number: 8604013
    Abstract: The present invention relates to methods for treating anemia in a subject having a low percent transferrin saturation by administering to the subject an effective amount of a compound that inhibits hypoxia-inducible factor prolyl hydroxylase activity.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 10, 2013
    Assignee: Fibrogen, Inc.
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Patent number: 8604012
    Abstract: The present invention relates to methods and compounds for increasing serum iron in a subject.
    Type: Grant
    Filed: July 12, 2010
    Date of Patent: December 10, 2013
    Assignee: Fibrogen, Inc.
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Patent number: 8530404
    Abstract: The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: September 10, 2013
    Assignee: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus
  • Publication number: 20130209451
    Abstract: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.
    Type: Application
    Filed: September 12, 2012
    Publication date: August 15, 2013
    Applicant: FibroGen, Inc.
    Inventors: Suzanne M. Spong, Thomas B. Neff, Stephen J. Klaus
  • Publication number: 20130203805
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: September 13, 2012
    Publication date: August 8, 2013
    Applicant: FIBROGEN, INC.
    Inventors: Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael P. Arend, Lee A. Flippin, Alex Melekhov
  • Patent number: 8318703
    Abstract: The invention relates to methods for improving renal (kidney) function. Methods for decreasing blood urea nitrogen (BUN), for increasing glomerular filtration rate (GFR), and for decreasing serum creatinine are also provided.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: November 27, 2012
    Assignee: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Qingjian Wang, Thomas B. Neff
  • Patent number: 8202834
    Abstract: The present invention provides methods and compounds for regulating fat metabolism and achieving fat homeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: June 19, 2012
    Assignee: FibroGen, Inc.
    Inventors: Patrick D. Fourney, Volkmar Guenzler-Pukall, Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Todd W. Seeley
  • Publication number: 20120149712
    Abstract: The invention relates to methods for improving renal (kidney) function. Methods for decreasing blood urea nitrogen (BUN), for increasing glomerular filtration rate (GFR), and for decreasing serum creatinine are also provided.
    Type: Application
    Filed: June 1, 2006
    Publication date: June 14, 2012
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Qingjian Wang, Thomas B. Neff
  • Patent number: 8124582
    Abstract: The present invention relates to methods and compounds for regulating glucose metabolism, achieving glucose homeostasis, and decreasing blood glucose levels. Methods and compounds for treating or preventing diabetes, hyperglycemia, and disorders and conditions associated with altered or impaired glucose metabolism are also provided.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: February 28, 2012
    Assignee: FibroGen, Inc.
    Inventors: Volkmar Guenzler-Pukall, Stephen J. Klaus, Ingrid Langsetmo Parobok, Todd W. Seeley