Patents by Inventor Stephen J. Klaus

Stephen J. Klaus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATMENT OF MULTIPLE SCLEROSIS
    Publication number: 20110263642
    Abstract: The present invention relates to methods and compounds useful for treating multiple sclerosis.
    Type: Application
    Filed: August 26, 2009
    Publication date: October 27, 2011
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Thomas B. Neff, Gail Walkinshaw
  • Compounds and Methods for Treatment of Stroke
    Publication number: 20110263644
    Abstract: The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.
    Type: Application
    Filed: July 11, 2011
    Publication date: October 27, 2011
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Ingrid Langsetmo Parobok, Christopher T. Jacob
  • Methods for treating anemia using inhibitors of hypoxia-inducible factor (HIF) hydroxylase
    Publication number: 20110166178
    Abstract: The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
    Type: Application
    Filed: February 17, 2011
    Publication date: July 7, 2011
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Al Y. Lin, Thoams B. Neff, Qingjian Wang, Volkmar Guenzler-Pukall, Michael P. Arend, Lee A. Flippin, Alex Melekhov
  • Enhanced erythropoiesis and iron metabolism
    Publication number: 20110039886
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: July 12, 2010
    Publication date: February 17, 2011
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Enhanced erythropoiesis and iron metabolism
    Publication number: 20110038950
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: July 12, 2010
    Publication date: February 17, 2011
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • METHODS FOR INCREASING ENDOTHELIAL PROGENITOR CELLS
    Publication number: 20110039885
    Abstract: The present invention relates to methods and compounds useful for increasing endothelial progenitor cell levels in blood and bone marrow. Methods and compounds for increasing endothelial progenitor cell mobilization are also provided.
    Type: Application
    Filed: December 8, 2008
    Publication date: February 17, 2011
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Ingrid Langsetmo Parobok, Oksana Sirenko
  • METHODS FOR INCREASING WHITE BLOOD CELLS
    Publication number: 20110039879
    Abstract: The present invention relates to methods and compounds useful for increasing white blood cell levels in blood and bone marrow. Methods and compounds for increasing hematopoietic progenitor cells are also provided.
    Type: Application
    Filed: December 8, 2008
    Publication date: February 17, 2011
    Applicant: FibroGen ,Inc.
    Inventors: Stephen J. Klaus, Ingrid Langsetmo Parobok
  • Compounds and methods for treatment of cancer-related anemia
    Publication number: 20110015223
    Abstract: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
    Type: Application
    Filed: August 16, 2010
    Publication date: January 20, 2011
    Applicant: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus
  • Treatment method for anemia
    Publication number: 20100331362
    Abstract: The present invention relates to improved methods for treating anemia. Methods and compounds useful for treating anemia, wherein the anemia treatment is associated with a lower risk of thrombosis or hypertension compared to that observed with rhEPO therapy, are provided.
    Type: Application
    Filed: August 26, 2010
    Publication date: December 30, 2010
    Applicant: FibroGen, Inc.
    Inventors: Stephen J. Klaus, Thomas B. Neff
  • Enhanced erythropoiesis and iron metabolism
    Publication number: 20100280044
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Enhanced erythropoiesis and iron metabolism
    Publication number: 20100278941
    Abstract: The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
    Type: Application
    Filed: July 12, 2010
    Publication date: November 4, 2010
    Inventors: Stephen J. Klaus, Christopher J. Molineaux, Thomas B. Neff, Volkmar Guenzler-Pukall, Ingrid Langsetmo Parobok, Todd W. Seeley, Robert C. Stephenson
  • Compounds and methods for treatment of chemotherapy-induced anemia
    Publication number: 20100204269
    Abstract: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
    Type: Application
    Filed: April 13, 2010
    Publication date: August 12, 2010
    Applicant: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus
  • Fat regulation
    Publication number: 20100168152
    Abstract: The present invention provides methods and compounds for regulating fat metabolism and achieving fat homeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
    Type: Application
    Filed: October 19, 2009
    Publication date: July 1, 2010
    Applicant: FibroGen, Inc.
    Inventors: Patrick D. Fourney, Volkmar Guenzler-Pukall, Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Todd W. Seeley
  • METHODS FOR INHIBITING T HELPER CELL DIFFERENTIATION
    Publication number: 20100144737
    Abstract: The present invention relates to methods and compounds useful for inhibiting T helper cell differentiation. Methods and compounds for decreasing IL-12 signaling in T helper cells are also provided.
    Type: Application
    Filed: December 8, 2008
    Publication date: June 10, 2010
    Applicant: FibroGen, Inc.
    Inventors: Felice Aisha Chow, Stephen J. Klaus, Ingrid Langsetmo Parobok
  • Compounds and methods for treatment of chemotherapy-induced anemia
    Patent number: 7713986
    Abstract: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
    Type: Grant
    Filed: June 15, 2006
    Date of Patent: May 11, 2010
    Assignee: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus
  • Fat regulation
    Patent number: 7618940
    Abstract: The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: November 17, 2009
    Assignee: FibroGen, Inc.
    Inventors: Patrick D. Fourney, Volkmar Guenzler-Pukall, Stephen J. Klaus, Al Y. Lin, Thomas B. Neff, Todd W. Seeley
  • Connective Tissue Growth Factor Signaling
    Publication number: 20080254487
    Abstract: The present invention provides compounds and agents that modulate CTGF-mediated cell adhesion and/or binding of CTGF to cells. The invention further provides assays that may be used to identify additional modulators of CTGF-mediated cell adhesion and CTGF binding to cells, and assays that may be used to identify compounds or agents that modulate interaction of CTGF with HSPGs.
    Type: Application
    Filed: January 14, 2005
    Publication date: October 16, 2008
    Applicant: FIBROGEN, INC.
    Inventors: Stephen J. Klaus, David Y. Liu, Irina Aizman
  • Treatments for cancer
    Publication number: 20080206256
    Abstract: The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.
    Type: Application
    Filed: April 23, 2008
    Publication date: August 28, 2008
    Applicant: FibroGen, Inc.
    Inventors: Suzanne M. Spong, Thomas B. Neff, Stephen J. Klaus
  • Compounds and methods for treatment of cancer-related anemia
    Publication number: 20070293575
    Abstract: The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.
    Type: Application
    Filed: June 15, 2006
    Publication date: December 20, 2007
    Applicant: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus
  • Compounds and methods for treatment of chemotherapy-induced anemia
    Publication number: 20070292433
    Abstract: The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
    Type: Application
    Filed: June 15, 2006
    Publication date: December 20, 2007
    Applicant: FibroGen, Inc.
    Inventors: Todd W. Seeley, David Y. Liu, Stephen J. Klaus