Abstract: Disclosed are novel pyrrole derivatives, a process for their manufacture, pharmaceutical compositions containing such compounds and the use of such compounds in the treatment of HIV mediated diseases.

Abstract: An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled. To optimize the cut, the laser parameters may be adjusted and/or the laser pulse may be shaped.

Abstract: The invention is concerned with novel benzodiazepine derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human papillomavirus E1 helicase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HPV mediated diseases.

Abstract: The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV infection.

Abstract: A method of preparing an executable program from a plurality of object code modules, at least one of said object code modules including section data specifying a plurality of functions associated with relocation instructions, at least some of which functions are called in the executable program. The method comprises the steps of assigning an attribute to each function, said attribute being capable of providing an indication of whether the function is reachable, reading the section data and relocation instructions to ascertain if the function is called and setting the attribute to indicate the called status and preparing the executable program to only include functions with an indicated called status of reachable.

Abstract: A sling for supporting a urethra in a patient has characteristics for resisting pull-out, roll-over and a combination of both pull-out and roll-over. To facilitate resistance to pull-out, sling material has protuberances or serrations to resist movement once placed in the patient by the surgeon. Improved resistance to roll-over or roll-up is achieved by providing relief on the sling in areas potentially subjected to roll-over forces by endopelvic fascia. The sling may be used on female or male patients, and may be used in conjunction with a wider support portion to support a bladder and a urethra, rather than a urethra alone. The sling may also be used to support other tissues within a patient.

Abstract: The invention is concerned with novel pyrazole derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV mediated process.

Abstract: A first communication node of a plurality of communication nodes connected with processorless central equipment in a system sends one or more first portions of node-output information to the processorless central equipment. One or more additional communication nodes of the plurality of communication nodes send one or more additional portions of node-output information to the processorless central equipment. The first communication node receives from the processorless central equipment a portion of central-output information. The portion of central-output information comprises the one or more first portions of node-output information and the one or more additional portions of node-output information.

Abstract: An improved expandable stent for implantation in a body lumen, such as an artery, and an improved method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cut cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements, the elements having a rectangular cross-section from cut-to-cut. The individual radially expandable cylindrical elements are disposed in an undulating pattern. The stent is manufactured by direct laser cutting from a single metal tube using a finely focused laser beam originating from a diode pumped fiber laser with an external pulse generator and passing through a coaxial gas jet structure to impinge on the working surface of the tube as the linear and rotary velocity of the tube is precisely controlled.

Abstract: The invention is concerned with novel imidazolone derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents against HIV infection.

Abstract: The present invention comprises novel and known pyrazole derivatives having anti-HIV activity, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds of formula I are inhibitors of the human immunodeficiency virus reverse transcriptase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HIV infection.

Abstract: A rocket engine (10) generates a flow of hot propulsion fluid through a nozzle (14N) for generating propulsive thrust along a thrust vector 8. Hybrid exhaust gas generators (36,38) have their exhausts (44,54) through the side of the nozzle. Each gas generator includes a fuel grain (46,56) and a source of oxidizer (16,40,50). The fuel grain is kept hot by either or both (a) direct radiation or conduction from the hot propulsion fluid, or (b) by a trickle of oxidizer. The fuel grain can thus react quickly to a substantial flow of oxidizer.

Abstract: The claimed invention relates to methods of modulating mucin synthesis and the therapeutic application of compounds in controlling mucin over-production associated with diseases such as chronic obstructive pulmonary diseases (COPD) including asthma and chronic bronchitis, inflammatory lung diseases, cystic fibrosis and acute or chronic respiratory infectious diseases.

Abstract: An overlapping or nesting connector is provided for connecting adjacent edge restraint sections. The edge restraint includes a substantially upright section and a base section, and may include braces extending between the upright section and the base section. The connector may be formed integrally with or separate from the edge restraint sections, and includes at least an upper wall, and optionally lateral walls and/or a rear wall. The upper wall may define an opening for a spike, and the brace or coupling structure with which the connector overlaps may define a corresponding opening for receiving the spike, which openings are aligned when the connector overlaps the brace. After adjacent edge restraints have been connected via the overlapping connector/brace, the spike is driven through the aligned openings into the underlying surface to provide a strong connection between the adjacent edge restraints and between the edge restraints and the underlying surface.

Abstract: The invention is concerned with novel benzodiazepine derivatives, a process for their manufacture, pharmaceutical compositions and the use of such compounds in medicine. In particular, the compounds are inhibitors of the human papillomavirus E1 helicase enzyme which is involved in viral replication. Consequently the compounds of this invention may be advantageously used as therapeutic agents for HPV mediateddiseases.

Abstract: A rocket engine (10) generates a flow of hot propulsion fluid through a nozzle (14N) for generating propulsive thrust along a thrust vector 8. One or more hybrid exhaust gas generators (36,38) have their exhausts (44,54) through the side of the nozzle. Each gas generator includes a fuel grain (46,56) and a source of oxidizer (16,40,50). The fuel grain produces exhaust gas only when oxidizer is provided. The fuel grain is kept hot by either or both (a) direct radiation or conduction from the hot propulsion fluid, or (b) by a trickle of oxidizer. The fuel grain can thus react quickly to a substantial flow of oxidizer. When the thrust vector is to be modified, the appropriate one of the hybrid gas generators receives a flow of oxidizer, and the resulting exhaust gas is injected through the side of the nozzle to disrupt the flow of propulsion fluid and modify the thrust vector.

Abstract: An overlapping or nesting connector is provided for connecting adjacent edge restraint sections. The edge restraint includes a substantially upright section and a base section, and may include braces-extending between the upright section and the base section. The connector may be formed integrally with or separate from the edge restraint sections, and includes at least an upper wall, and optionally lateral walls and/or a rear wall. The upper wall may define an opening for a spike, and the brace or coupling structure with which the connector overlaps may define a corresponding opening for receiving the spike, which openings are aligned when the connector overlaps the brace. After adjacent edge restraints have been connected via the overlapping connector/brace, the spike is driven through the aligned openings into the underlying surface to provide a strong connection between the adjacent edge restraints and between the edge restraints and the underlying surface.

Abstract: The invention is concerned with amino acid derivatives of the formula and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.

Abstract: A rocket engine (10) generates a flow of hot propulsion fluid through a nozzle (14N). Hybrid exhaust gas generators (36,38) have their exhausts (44,54) through the side of the nozzle. Each gas generator includes a fuel grain (46,56) and a source of oxidizer (16,40,50). The fuel grain is kept hot by either or both (a) direct radiation or conduction from the hot propulsion fluid, or (b) by a trickle of oxidizer. When the thrust vector is to be modified, the appropriate one of the hybrid gas generators receives a flow of oxidizer, and the resulting exhaust gas is injected through the side of the nozzle.

Abstract: A non-crosslinked biocompatible polymer is formed from a radical polymerisable ethylenically unsaturated zwitterionic monomer containing a sulpho-betaine zwitterionic group and a radical polymerisable ethylenically unsaturated comonomer containing a hydrophobic group selected from C6-24-alkyl, C1-24-fluoroalkyl and siloxane groups. Suitable copolymers are of N,N-dimethyl ammonium-N-propylsulphonate-N-ethyl methacrylate and dodecylmethacrylate. The polymer may be used to coat substrates to render them biocompatible, especially hemocompatible. The hydrophobic groups render the polymer particularly suitable for coating hydrophobic substrates.