Patents by Inventor Stephen Lewis

Stephen Lewis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210081508
    Abstract: Various implementations described herein are directed to an integrated circuit (IC) having a design that is severable into multiple sub-circuits having input-output (IO) ports. The integrated circuit (IC) may include multiple physical electrical connections that are adapted to electrically interconnect the IO ports of the multiple sub-circuits to operate as the IC, and the IO ports have three-dimensional (3D) geometric position information associated therewith.
    Type: Application
    Filed: September 12, 2019
    Publication date: March 18, 2021
    Inventors: Xiaoqing Xu, Brian Tracy Cline, Saurabh Pijuskumar Sinha, Stephen Lewis Moore, Mudit Bhargava
  • Patent number: 10883910
    Abstract: An apparatus and method for condensationally enlarging particles in a flow of air or other gas. The apparatus includes a coiled tube having a tube diameter and a coil diameter, the tube having an input receiving the flow and an output, the tube having a length between the input and the output. The walls of the tube are wetted with a condensing fluid. The walls of the first portion of the coiled tube are held a temperature that is lower than the highest temperature in the second portion of the tube. The tube may have a third vapor recovery portion with wall temperature lower than the highest temperature in the second portion, and which optionally may not be coiled. While heating and cooling, the method includes introducing a flow into an interior of the tube at an input, the flow moving the output.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: January 5, 2021
    Assignee: Aerosol Dynamics Inc.
    Inventors: Susanne Vera Hering, Steven Russel Spielman, Gregory Stephen Lewis
  • Patent number: 10881633
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Benjamin Gaston, Stephen Lewis
  • Patent number: 10882018
    Abstract: An apparatus and method for creating enlarged particles in a flow. The apparatus includes a coiled tube having a tube diameter and a coil diameter, the tube having an input receiving the flow and an output, the tube having a length between the input and the output. A heater heats a first portion of the tube along a first, longitudinal portion of the tube, and a cooler cools a second, longitudinal portion of the tube along at least a second portion of the tube. The method includes heating a first portion of the tube along a first longitudinal portion of the tube, and simultaneously cooling a second portion of the tube along at least a second longitudinal portion of the tube. While heating and cooling, the method includes introducing a flow into an interior of the tube at an input, the flow moving the output.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: January 5, 2021
    Assignee: Aerosol Dynamics Inc.
    Inventors: Susanne Vera Hering, Steven Russel Spielman, Gregory Stephen Lewis
  • Publication number: 20200407675
    Abstract: An apparatus and method for the delivery and deposition of particles air-liquid-interface (ALI) cell cultures includes a sample inlet coupled to a growth tube having interior walls that are wet. The growth tube is configured to operate at a first temperature along a first length of the tube and a second temperature along a second length positioned between the first length and a growth tube outlet. The apparatus also includes a nozzle plate having a plurality of nozzles. The exposure chamber adapted to hold cell cultures at an air-liquid interface positioned underneath the plurality of nozzles and a temperature regulator adapted to control a temperature of the exposure chamber. The apparatus also includes a controller including instructions operable to cause the controller to maintain a relative humidity within the exposure chamber by controlling at least the second temperature of the growth tube and the temperature of the exposure chamber.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 31, 2020
    Inventors: Arantzazu Eiguren Fernandez, Gregory Stephen Lewis, Steven Russel Spielman, Chang-Yu Wu, Trevor Benson Tilly
  • Publication number: 20200408931
    Abstract: An approach for counting particles suspended in a flow of gas or liquid in instruments that direct the flow through an illuminated region. Pulses are detected when the signal is below a threshold amplitude and moves above the threshold amplitude. This movement above the threshold creates a dead time during which only one pulse is detected until the signal amplitude moves sufficiently below the threshold such that a subsequent particle creates a distinct pulse. After counting the number of pulses, and determining the measured live time that the signal is below the threshold value, an initial particle concentration is calculated, and the calculation corrected for coincidence by calculating an actual live time as a measured live time minus a constant multiplied by the number of distinctly counted pulses, where the constant has the units of time. From this, particle concentrations in a volume can be determined.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 31, 2020
    Applicant: Aerosol Dynamics Inc.
    Inventors: Susanne Vera Hering, Gregory Stephen Lewis, Steven Russel Spielman
  • Publication number: 20200279067
    Abstract: Implementations described herein are directed to a device with a processor and memory having stored thereon instructions that, when executed by the processor, cause the processor to acquire an integrated circuit layout of physical cells from a database and define wirelength relationships between input/output connections and a cell count for the physical cells in multiple domains. The instructions may cause the processor to define wirelength parameters of the integrated circuit layout in each domain of the multiple domains and generate a data file for the integrated circuit layout of the physical cells based on the wirelength relationships and the wirelength parameters to guide power and performance of the integrated circuit layout of the physical cells. The instructions may cause the processor to fabricate, or contribute to the fabrication of, an integrated circuit based on the data file for the integrated circuit layout of the physical cells.
    Type: Application
    Filed: May 18, 2020
    Publication date: September 3, 2020
    Inventors: Divya Madapusi Srinivas Prasad, Saurabh Pijuskumar Sinha, Brian Tracy Cline, Stephen Lewis Moore
  • Publication number: 20200247822
    Abstract: The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably. Alzheimer's disease.
    Type: Application
    Filed: April 22, 2020
    Publication date: August 6, 2020
    Inventors: Jon James Winter-Holt, Edward Giles Mciver, Martin Ambler, Stephen Lewis, Joanne Osborne, Kayleigh Webb-Smith
  • Publication number: 20200218845
    Abstract: Various implementations described herein are directed to a method that defines tiers of an integrated circuit having standard cells placed adjacent to each other in a multi-tier placement. The integrated circuit includes multi-tier nets connected with inter-tier connections. The method includes pairing inter-tier connections as inter-tier-connection pairs belonging to a same net. The method includes grouping standard cells in groups with or without inter-tier-connection pairs from the tiers. The method includes relating the standard cells with or without inter-tier-connection pairs within each group from the groups by generating a multi-tier fence boundary around physical locations of the standard cells with or without inter-tier-connection pairs.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Inventors: Xiaoqing Xu, Brian Tracy Cline, Stephen Lewis Moore, Saurabh Pijuskumar Sinha
  • Patent number: 10669284
    Abstract: The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably, Alzheimer's disease.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: June 2, 2020
    Assignee: LIFEARC
    Inventors: Jon James Winter-Holt, Edward Giles Mciver, Martin Ambler, Stephen Lewis, Joanne Osborne, Kayleigh Webb-Smith
  • Patent number: 10657218
    Abstract: Implementations described herein are directed to a device with a processor and memory having stored thereon instructions that, when executed by the processor, cause the processor to acquire an integrated circuit layout of physical cells from a database and define wirelength relationships between input/output connections and a cell count for the physical cells in multiple domains. The instructions may cause the processor to define wirelength parameters of the integrated circuit layout in each domain of the multiple domains and generate a data file for the integrated circuit layout of the physical cells based on the wirelength relationships and the wirelength parameters to guide power and performance of the integrated circuit layout of the physical cells. The instructions may cause the processor to fabricate, or contribute to the fabrication of, an integrated circuit based on the data file for the integrated circuit layout of the physical cells.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 19, 2020
    Assignee: Arm Limited
    Inventors: Divya Madapusi Srinivas Prasad, Saurabh Pijuskumar Sinha, Brian Tracy Cline, Stephen Lewis Moore
  • Publication number: 20200138787
    Abstract: A composition for opththalmic administration comprising a formaldehyde releasing agent, sodium bicarbonate, and an ophthalmically suitable carrier or excipient is provided.
    Type: Application
    Filed: May 20, 2019
    Publication date: May 7, 2020
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: David Choohyun Paik, Stephen Lewis Trokel
  • Publication number: 20200141853
    Abstract: A particle growth apparatus includes a temperature-controlled humidifier coupled to a water-based condensation growth system. The humidifier may include a tube of sulfonated tetrafluoroethylene-based fluoropolymer-copolymer and surrounded by a region containing water or water vapor. The apparatus includes a wetted wick and wick sensor in the condensation growth system, configured such that the gas sample flows through the sulfonated tetrafluoroethylene-based fluoropolymer-copolymer tube into the condensation growth system.
    Type: Application
    Filed: November 1, 2019
    Publication date: May 7, 2020
    Applicant: Aerosol Dynamics Inc.
    Inventors: Susanne Vera Hering, Arantzazu Eiguren Fernandez, Gregory Stephen Lewis, Steven Russel Spielman, Philip Bougouis
  • Publication number: 20200116619
    Abstract: A wick liquid sensor suitable for use in a particle condensation device is provided. The sensor includes a light source configured to illuminate a surface of the wick. A detector is configured to detect wick reflected light from the light source and determine the intensity of reflected light. The wick is formed from a porous media that is wettable by the liquid, and becomes translucent when filled with the liquid. The amount of reflectivity decreases as the saturation content of the liquid in the wick increases.
    Type: Application
    Filed: October 12, 2018
    Publication date: April 16, 2020
    Applicant: Aerosol Dynamics Inc.
    Inventors: Susanne Vera Hering, Steven Russel Spielman, Gregory Stephen Lewis
  • Patent number: 10604524
    Abstract: The present invention relates to compounds of formulae I, or pharmaceutically acceptable salts or esters thereof, wherein: R1 is selected from H and CO—NR8R9, wherein R8 and R9 are each independently selected from H, alkyl, cycloalkyl and mono or bicyclic heterocycloalkyl, wherein said alkyl group is optionally substituted by one or more R12 groups, and said heterocycloalkyl is optionally substituted by R10 or R12; or R8 and R9 are linked, together with the nitrogen to which they are attached, to form a heterocycloalkyl group optionally containing one or more additional heteroatoms, and optionally substituted by one or more groups select from R10 and (CH2)mR12; R2 is selected from H and alkyl, wherein said alkyl group is optionally substituted by one or more R12 groups; R3 is selected from alkyl, cycloalkyl and heterocycloalkyl, each of which may be optionally substituted by halo, OH or alkoxy; Z1, Z2, Z3 and Z4 are all C; R4, R5, R6 and R7 are each independently selected from H, alkyl, CN, NO2, OH, alkoxy, N
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: March 31, 2020
    Assignee: LIFE ARC
    Inventors: Jon James Winter-Holt, Edward Giles Mciver, Stephen Lewis, Joanne Osborne
  • Patent number: 10599806
    Abstract: Various implementations described herein are directed to a method that defines tiers of an integrated circuit having standard cells placed adjacent to each other in a multi-tier placement. The integrated circuit includes multi-tier nets connected with inter-tier connections. The method includes pairing inter-tier connections as inter-tier-connection pairs belonging to a same net. The method includes grouping standard cells in groups with or without the inter-tier-connection pairs from the tiers. The method includes relating the standard cells with or without the inter-tier-connection pairs within each group from the groups by generating a multi-tier fence boundary around physical locations of the standard cells with or without the inter-tier-connection pairs.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: March 24, 2020
    Assignee: Arm Limited
    Inventors: Xiaoqing Xu, Brian Tracy Cline, Stephen Lewis Moore, Saurabh Pijuskumar Sinha
  • Patent number: 10543187
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: January 28, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Benjamin Gaston, Stephen Lewis
  • Publication number: 20190358189
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 28, 2019
    Inventors: Benjamin Gaston, Stephen Lewis
  • Publication number: 20190298914
    Abstract: A wearable infusion pump assembly includes a reservoir for receiving an infusible fluid, and an external infusion set configured to deliver the infusible fluid to a user. A fluid delivery system is configured to deliver the infusible fluid from the reservoir to the external infusion set. The fluid delivery system includes a volume sensor assembly, and a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the volume sensor assembly. The volume sensor assembly is configured to determine the volume of at least a portion of the quantity of fluid. The fluid delivery system further includes a first valve assembly configured to selectively isolate the pump assembly from the reservoir, and a second valve assembly configured to selectively isolate the volume sensor assembly from the external infusion set.
    Type: Application
    Filed: April 29, 2019
    Publication date: October 3, 2019
    Inventors: Dean Kamen, Larry Brian Gray, Richard J. Lanigan, John Matthew Kerwin, Stephen Lewis Fichera
  • Patent number: D872193
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: January 7, 2020
    Inventor: Stephen Lewis