Abstract: A system includes a first and second condensation particle counter, each counter having an inlet port, a growth column, and an optical element for counting particles detected at the respective inlet ports. The counters are configured to include a wick in which the wick is wetted by water. A differential pressure sensor is coupled to the first inlet port and coupled to the second inlet port. The sensor is configured to provide a pressure signal. A processor is coupled to memory and configured to receive the first signal, the second signal, and the pressure signal and generate an output corresponding to a ratio of the first signal and the second signal and correlate the ratio with the pressure signal. A housing is configured to receive the first counter, the second counter, the differential pressure sensor, the processor, and the memory.

Abstract: The present invention relates to compounds of formulae I and H, or pharmaceutically acceptable salts or esters thereof. Further aspects of the invention relate to pharmaceutical compositions and therapeutic uses of said compounds in the treatment of diseases of uncontrolled cell growth, proliferation and/or survival, inappropriate cellular immune responses, inappropriate cellular inflammatory responses, or neurodegenerative disorders, preferably tauopathies, even more preferably. Alzheimer's disease.

Abstract: Packaging for tobacco industry products is disclosed. The packaging comprises a pack (2) for holding tobacco industry products, and an outer wrapper (3) enveloping the pack. The outer wrapper comprises a removable portion (17) arranged to prevent opening of the pack until the removable portion has been removed. One of the pack and the removable portion comprises a tamper evident feature that remains attached to the other of the pack or the removable portion after the removable portion is removed from the pack. A method of packaging tobacco industry products is also disclosed.

Abstract: Implementations described herein are directed to a device with a processor and memory having stored thereon instructions that, when executed by the processor, cause the processor to acquire an integrated circuit layout of physical cells from a database and define wirelength relationships between input/output connections and a cell count for the physical cells in multiple domains. The instructions may cause the processor to define wirelength parameters of the integrated circuit layout in each domain of the multiple domains and generate a data file for the integrated circuit layout of the physical cells based on the wirelength relationships and the wirelength parameters to guide power and performance of the integrated circuit layout of the physical cells. The instructions may cause the processor to fabricate, or contribute to the fabrication of, an integrated circuit based on the data file for the integrated circuit layout of the physical cells.

Abstract: Various implementations described herein are directed to a method that defines tiers of an integrated circuit having standard cells placed adjacent to each other in a multi-tier placement. The integrated circuit includes multi-tier nets connected with inter-tier connections. The method includes pairing inter-tier connections as inter-tier-connection pairs belonging to a same net. The method includes grouping standard cells in groups with or without inter-tier-connection pairs from the tiers. The method includes relating the standard cells with or without inter-tier-connection pairs within each group from the groups by generating a multi-tier fence boundary around physical locations of the standard cells with or without inter-tier-connection pairs.

Abstract: A lipid comprising a tri-chain cation having a cationic head group and three or more C7-24 hydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.

Abstract: Systems and methods of reducing false alarms associated with a vital-sign monitor are disclosed. One or more data samples of a vital sign of a patient are generated at a first sampling rate in a normal mode of operation. Whether the one or more data samples satisfy an alert condition is determined. An alert mode of operation is entered into if the alert condition is satisfied. One or more additional data samples of the vital sign are generated at a second sampling rate higher than the first sampling rate in the alert mode.

Abstract: A ribonucleoprotein (RNP) delivery system comprising (a) a cationic lipid; (b) a phospholipid; (c) a peptide of the structure A-B-C in which A is a polycationic nucleic acid-binding component, B is a spacer element comprising two or more amino acid residues, and C is a cell surface receptor binding component; and (d) a ribonucleoprotein (RNP) complex comprising a CRISPR-associated protein and guide RNA, pharmaceutical compositions comprising such a ribonucleoprotein (RNP) delivery system, and methods for the treatment or prophylaxis of a condition caused in a human or in a non-human animal by a defect and/or a deficiency in a gene, or for RNA therapy, or for the treatment of a cancer, which comprises administering the RNP delivery system or pharmaceutical composition to the human or to the non-human animal.

Abstract: A liposome comprising a cationic lipid, a phospholipid and a peptide and optionally consisting of from 20 to 50% by molarity cholesterol, based on the total amount of lipids, for use in non-viral gene delivery systems, for example, in the formation of lipopolyplex transfection vectors for the delivery of mRNA to cells.

Abstract: A wick liquid sensor suitable for use in a particle condensation device is provided. The sensor includes a light source configured to illuminate a surface of the wick. A detector is configured to detect wick reflected light from the light source and determine the intensity of reflected light. The wick is formed from a porous media that is wettable by the liquid, and becomes translucent when filled with the liquid. The amount of reflectivity decreases as the saturation content of the liquid in the wick increases.

Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.

Abstract: Various implementations described herein are directed to an integrated circuit (IC) having a design that is severable into multiple sub-circuits having input-output (IO) ports. The integrated circuit (IC) may include multiple physical electrical connections that are adapted to electrically interconnect the IO ports of the multiple sub-circuits to operate as the IC, and the IO ports have three-dimensional (3D) geometric position information associated therewith.

Abstract: An apparatus and method for creating enlarged particles in a flow. The apparatus includes a coiled tube having a tube diameter and a coil diameter, the tube having an input receiving the flow and an output, the tube having a length between the input and the output. A heater heats a first portion of the tube along a first, longitudinal portion of the tube, and a cooler cools a second, longitudinal portion of the tube along at least a second portion of the tube. The method includes heating a first portion of the tube along a first longitudinal portion of the tube, and simultaneously cooling a second portion of the tube along at least a second longitudinal portion of the tube. While heating and cooling, the method includes introducing a flow into an interior of the tube at an input, the flow moving the output.

Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.

Abstract: An apparatus and method for condensationally enlarging particles in a flow of air or other gas. The apparatus includes a coiled tube having a tube diameter and a coil diameter, the tube having an input receiving the flow and an output, the tube having a length between the input and the output. The walls of the tube are wetted with a condensing fluid. The walls of the first portion of the coiled tube are held a temperature that is lower than the highest temperature in the second portion of the tube. The tube may have a third vapor recovery portion with wall temperature lower than the highest temperature in the second portion, and which optionally may not be coiled. While heating and cooling, the method includes introducing a flow into an interior of the tube at an input, the flow moving the output.

Abstract: An apparatus and method for the delivery and deposition of particles air-liquid-interface (ALI) cell cultures includes a sample inlet coupled to a growth tube having interior walls that are wet. The growth tube is configured to operate at a first temperature along a first length of the tube and a second temperature along a second length positioned between the first length and a growth tube outlet. The apparatus also includes a nozzle plate having a plurality of nozzles. The exposure chamber adapted to hold cell cultures at an air-liquid interface positioned underneath the plurality of nozzles and a temperature regulator adapted to control a temperature of the exposure chamber. The apparatus also includes a controller including instructions operable to cause the controller to maintain a relative humidity within the exposure chamber by controlling at least the second temperature of the growth tube and the temperature of the exposure chamber.

Abstract: An approach for counting particles suspended in a flow of gas or liquid in instruments that direct the flow through an illuminated region. Pulses are detected when the signal is below a threshold amplitude and moves above the threshold amplitude. This movement above the threshold creates a dead time during which only one pulse is detected until the signal amplitude moves sufficiently below the threshold such that a subsequent particle creates a distinct pulse. After counting the number of pulses, and determining the measured live time that the signal is below the threshold value, an initial particle concentration is calculated, and the calculation corrected for coincidence by calculating an actual live time as a measured live time minus a constant multiplied by the number of distinctly counted pulses, where the constant has the units of time. From this, particle concentrations in a volume can be determined.

Abstract: Implementations described herein are directed to a device with a processor and memory having stored thereon instructions that, when executed by the processor, cause the processor to acquire an integrated circuit layout of physical cells from a database and define wirelength relationships between input/output connections and a cell count for the physical cells in multiple domains. The instructions may cause the processor to define wirelength parameters of the integrated circuit layout in each domain of the multiple domains and generate a data file for the integrated circuit layout of the physical cells based on the wirelength relationships and the wirelength parameters to guide power and performance of the integrated circuit layout of the physical cells. The instructions may cause the processor to fabricate, or contribute to the fabrication of, an integrated circuit based on the data file for the integrated circuit layout of the physical cells.