Abstract: The present invention relates to a combination of a 6-axis motion sensor having a 3-axis gyroscope and a 3-axis linear accelerometer, a motion processor and a radio integrated circuit chip (IC), wherein the intelligence in the motion processor enables the communication between the motion sensor, the radio IC and the external network. The motion processor also enables power savings by adaptively controlling the data rate of the motion sensor, depending on the amount or speed of the motion activity.

Abstract: Disclosed herein is the identification of human DNA polymerase ? (pol ?) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a number of chemotherapeutic and antimicrobial agents is the induction of ICLs. Thus, provided herein is a method of enhancing the efficacy of a chemotherapeutic or antimicrobial agent in a subject, including selecting a subject in need of treatment with an ICL-inducing agent and administering to the subject an ICL-inducing agent and a therapeutically effective amount of an inhibitor of pol ?. Subjects in need of treatment with an ICL-inducing agent, include, for example, subjects diagnosed with a hyperproliferative disease, an autoimmune disease or an infectious disease. Also provided is a composition for treating a hyperproliferative disease, an autoimmune disease or an infectious disease, comprising an ICL-inducing agent and an amount of an inhibitor of pol ? sufficient to enhance the efficacy of the ICL-inducing agent.

Abstract: Described herein are pyrimidine dimer-specific glycosylase (PDG) polypeptides and methods of use for repair of damaged DNA. The PDG polypeptides comprise amino acid sequence from T4-PDG, CV-PDG or engineered mutants thereof. The PDG polypeptides further comprise a targeting sequence, such as a nuclear targeting sequence or a mitochondrial targeting sequence, and a protein transduction domain. The mutant PDG polypeptides described herein retain at least some catalytic activity while exhibiting reduced cytotoxicity in wild-type cells.

Abstract: A strain of Francisella species in which gene FTT1564, or homologue thereof, has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein additional genes are also inactivated. Pharmaceutical compositions comprising said strains, together with methods of preventing and treating tularemia infection, which utilise such strains, are also described and claimed.

Abstract: A strain of Francisella species wherein a gene which encodes for part of the glutamate metabolic pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as live prophylactic or therapeutic vaccine against infection by said Francisella species. Particularly effective strains include those where the capB gene is deleted. Other embodiments of the invention describe strains which comprise a further genetic mutation wherein a gene which encodes for another component of the cell is also inactivated. Pharmaceutical compositions comprising said strains, together with methods which utilise such strains are also described and claimed.

Abstract: The invention is a non-cash media sheet for use in an automatic teller machine or like device, from which one or more cards can be separated from the sheet. Two of the cards are joined along a fold line, and fold into a transaction card with a thickness similar to standard transaction cards and readable by readers of standard thickness transaction cards.

Abstract: A non-cash media card which is dispensable through automated teller machines (ATM's), with the card having information which identifies a particular customer and the particular transaction by which the card was purchased. The invention is also a process for dispensing the non-cash media card from an automated teller machine, by which a non-cash media card is dispensed through the same mechanism as cash is dispensed, and the ATM machine is configured to embed the purchaser and transaction specific information on the card, and read the information to verify it.

Abstract: A strain of Francisella species wherein a gene which encodes an enzyme in the purine pathway has been inactivated, and which is able to produce a protective immune response in an animal, for use as a live prophylactic or therapeutic vaccine against infection by said Francisella species. Suitable genes for inactivation include the purF gene. Pharmaceutical compositions and methods which utilise these strains are also described and claimed.

Abstract: The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably an exogenous target sequence. The invention includes polynucleotides that include a coding sequence encoding the polypeptides of the present invention. Also provided by the invention are methods of using the polypeptides.

Abstract: The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably an exogenous target sequence. The invention includes polynucleotides that include a coding sequence encoding the polypeptides of the present invention. Also provided by the invention are methods of using the polypeptides.

Abstract: A novel mechanism is disclosed by which a sender can direct information such as an audiovisual signal to a particular recipient's audiovisual display device, such as a cable television set and, thereby, share information between the sender and the recipient. In one embodiment of the invention, a calling party originates a telephone call and associates that telephone call with audio-visual information that exists on the caller's personal computer or on an Internet server. The called party answers the call, and can tune an associated cable television to the appropriate channel in order to view the audiovisual information. The caller can modify the audio-visual information during the call. Accordingly, the current invention ties together the telephone, cable, and IP networks in a manner that does not require large investments from cable or telephone service providers.

Abstract: A non-cash media card which is dispensable through automated teller machines (ATM's) and a process for dispensing a non-cash media card from an automated teller machine, by which a non-cash media card is dispensed through the same mechanism as cash is dispensed. The non-cash media card can have separable portions, or be redeemable for goods or services, or may allow the bearer entry to an event or a location. One version of this type of card has a removable portion which is credit card size and can contain memory storage media. Information on the memory storage media can be later read, modified, and have its value reduced or augmented by subsequent uses.

Abstract: A luggage carrier assembly including a luggage carrier and a pair of latching mechanisms mounted on the luggage carrier for securing the luggage carrier to a motorcycle mount upon movement of the luggage carrier toward the mount. The luggage carrier includes a pair of side plates each having a recess engageable with the mount, and the latching mechanisms each include a latch member pivotally mounted on the side plates movable relative to the side plates between an unlatched position, in which the recesses are engageable and disengageable with the mount, and a latched position, in which the recess is held in engagement with the mount. The luggage carrier further includes a locking member movable relative to the latch member between an unlocked position, in which the latch member is movable between the latched and unlatched positions, and a locked position, in which the latch member is held in the latched position.

Abstract: A T4 endonuclease V DNA repair enzyme contains an amino acid sequence within its carboxyl terminal region which is involved in dimer specific binding. The region includes polar nonaromatic basic amino acids and aromatic amino acids between amino acid 128 to 137 positions. The specific activity of the enzyme is greatly increased at low salt concentrations when substitutions are made in aromatic amino acids in the carboxy terminal region.

Abstract: A sleep posture monitor and alarm system detects one or more of four possible sleep positions and sounds an alarm when an individual wearing the apparatus assumes one or more of the detected positions. In addition, interface units for providing a monitoring output of the device to a polysomnograph are included as well as circuitry to record the commutative total time spent by the individual when in the selected positions.