Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: An annular seal cavity throat bushing includes an inner annular surface having a substantially latitudinal channel with the channel being provided with at least one orifice to allow fluid communication between the inside of the bushing and the outside of the bushing. The bushing is further provided with at least one groove extending substantially longitudinally from one end of the bushing to the channel. The groove has at least one tapered edge which increases the width of the groove along its length.

Abstract: A computer-implemented process includes: receiving into a computer memory a response to a generic question not specifically related to handwriting style; converting the response into one or more tags representing handwriting characteristics; selecting a typeface having a handwriting characteristic of one of the tags; receiving a text string to display into a computer memory; and displaying the text string by rendering glyphs from a font file containing glyphs for the selected typeface, after applying random variations to simulate human handwriting variation.

Abstract: The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.

Abstract: The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Abstract: Techniques to provide a micro-broadcast of an event are described. Video data streams of a live event at a venue may be captured in one or more wireless camera devices. The data streams may be sent to one of a network of wireless access points where they are relayed to a control center. A computer system in the control center may select one of the video data streams to be broadcast as a micro-broadcast. The selected video data stream may then be formatted for the micro-broadcast before a micro-broadcast transmitter broadcasts the formatted selected video data stream.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the formulation is free of organic solvents. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one cleaning material and, in this embodiment, it is preferred that the polymeric particles are coated with the at least one cleaning material. Preferably, the cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of nylon, most preferably in the form of nylon chips.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.

Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

Abstract: Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.

Abstract: The invention provides a method for the drying of a wet substrate, the method comprising treating the substrate with a solid particulate material at ambient or elevated temperature, the treatment being carried out in an apparatus comprising a drum comprising perforated side walls, wherein the drum comprising perforated side walls is rotated so as to facilitate increased mechanical action between the substrate and the particulate material. Preferably, the drum comprising perforated side walls has a capacity of between 5 and 50 litres for each kg of fabric in the load and is rotated at a speed which generates G forces in the range of from 0.05 to 0.99 G, and the method is carried out at a temperature of between 5° and 120° C. Preferably, the solid particulate material comprises a multiplicity of particles at a particle to fabric addition level of 0.1:1-10:1 by mass, wherein the particles comprise polymeric particles, non-polymeric particles, or mixtures of polymeric and non-polymeric particles.

Abstract: The invention provides a method and formulation for cleaning a soiled substrate, the method comprising the treatment of the moistened substrate with a formulation comprising a multiplicity of polymeric particles, wherein the polymeric particles comprise at least one antimicrobial agent. Preferably, the substrate is wetted so as to achieve a substrate to water ratio of between 1:0.1 to 1:5 w/w. Optionally, the formulation additionally comprises at least one additional cleaning agent and, in this embodiment, it is preferred that the polymeric particles are mixed with the at least one additional cleaning agent. Preferably, the additional cleaning material comprises a surfactant, which most preferably has detergent properties. Most preferably, the substrate comprises a textile fibre. Typically, the polymeric particles comprise particles of polyester or nylon, most preferably in the form of beads.

Abstract: In one embodiment, a kit for making a touch-sensitive personalized display includes a blank foldable to form a cavity, a print medium including a personalized print medium with a personalization surface to receive a user selected-image, and touch-sensing system is to be at least partially contained within the cavity, the system to detect a mechanical wave in the blank, and to trigger an action at an electronic device responsive to detection of the wave. In another embodiment, a touch-sensitive personalized display includes a blank including extensions folded towards a back surface to form a cavity, a print medium including a personalization surface upon which a user-selected image has been printed via a digital printer, and a touch-sensing system, positioned at least partially within the cavity, to trigger a an action at an electronic device.

Abstract: In one embodiment, a kit for making a personalized display includes a blank foldable to form a cavity according to score lines to form a display with a cavity, a print medium to receive a user selected-image and to adhere to the blank, and a bending wave generation unit attachable to a display element to receive a signal from a signal generator and produce bending waves within the display element that cause the display element to vibrate and generate audible acoustic waves in accordance with the signal. In another embodiment, a personalized display includes a blank with extensions folded to form a cavity, a print medium adhered to the blank and with a user-selected image printed via a digital printer, and a bending wave generation unit attached to a display element and positioned within the cavity.

Abstract: A method of making a sheared wool, deep pile fabric that closely resembles natural sheepskin fleece that includes forming a length of wool pile fabric having natural wool fibers on one side and a scrim on an opposing side and finishing the wool pile fabric as natural shearling. The finishing process includes polishing the wool fiber side of the pile fabric by guiding the length of pile fabric over one or more heated first polishing rolls, applying a sheepskin conditioning solution to the wool fiber side of the pile fabric, further polishing the wool fiber side of the pile fabric by guiding the fabric a plurality of times over one or more second heated polishing rolls, and cutting the wool fibers to a designated length.

Abstract: Methods and systems for facilitating combined co-registration and image pixel calibration of multimodal data are provided. According to one embodiment, a first set of digital image data is received that includes pixel data associated with a portion of a patient's anatomy and a fiducial system. A second set of digital image data is received that includes pixel data associated with the portion of the patient's anatomy and the fiducial system. One or both of the sets of digital image data are adjusted, calibrated, modified or verified based on known characteristics of the fiducial system. A composite model of the portion of the patient's anatomy is generated by co-registering the two sets of digital image data based on the pixel data associated with the fiducial system.