Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxyg

Abstract: A urology catheter is provided that includes an elongated body extending from a proximal end to a distal end. The body defines at least one lumen. A tip has a proximal end that is disposed in abutting relation with the distal end of the body such that the body is fixed with the tip. The tip defines a lateral opening that is defined by a wall including an external radius disposed in transition with an outer surface of the tip and an internal radius disposed in transition with an inner surface of the tip. The external radius has a non-perpendicular profile with the outer surface of the tip. An expandable member has a proximal portion disposed about the body and a distal portion disposed about the tip. A method of manufacturing the urology catheter is provided.

Abstract: In accordance with the present invention, a casting system is provided which broadly comprises a core and a wax die spaced from said core, a refractory metal core having a first end seated within a slot in the core and a second end contacting the wax die for positioning the core relative to the wax die, and the refractory metal core having at least one of a mechanism for providing spring loading when closed in the wax die and a mechanism for mechanically locking the wax die to the core.

Abstract: There is disclosed a continuously variable ratio transmission assembly (“variator”) comprising a roller which transmits drive between a pair of races, the roller being movable in accordance with changes in variator ratio, a hydraulic actuator which applies a biasing force to the roller, at least one valve connected to the actuator through a hydraulic line to control pressure applied to the actuator and so to control the biasing force, and an electronic control which determines the required biasing force and sets the valve accordingly, characterised in that the valve setting is additionally dependent upon a rate of flow in the hydraulic line.

Abstract: A method is disclosed for obtaining a signal representing motor vehicle acceleration. The method involves obtaining a high pass filtered vehicle acceleration signal and a low pass filtered vehicle acceleration signal. One of these signals (preferably the high pass filtered signal) is obtained based upon the net driving force applied to the vehicle, which can be used to obtain an estimate of acceleration by means of an adoptive vehicle model (28). The other signal is obtained by measurement, for example by differentiating a measured vehicle speed signal with respect to time. Adding the two filtered signals together gives a vehicle acceleration signal of potentially good quality.

Abstract: A sacrificial core is used for forming an interior space of a part and includes a ceramic core element and a first core element including a refractory metal element. The ceramic core element may be molded over the first core element or molded with assembly features permitting assembly with the first core element.

Abstract: There is described a controller for motor vehicle drive train comprising an engine and a continuously variable ratio transmission providing geared neutral, the controller serving to set demands for wheel torque and engine speed in dependence upon a driver input, characterised in that the controller is adapted to respond to input from the driver indicative of a requirement for an engine speed increase prior to vehicle launch by raising engine speed while implementing a reduced wheel torque strategy, and to subsequently raise wheel torque following input from the vehicle driver by which launch is initiated.

Abstract: The invention relates to a refrigerator for storing vials containing a (bio)pharmaceutical substance, in particular vaccines for animals, comprising a cabinet having an internal space for accommodating the vials arranged in columns, a cooling element for cooling the internal space and at least one door or dispenser for removing vials from the internal space. A plurality of guides located inside the space and adapted to slidingly accommodate columns of the vials. The invention further relates to a cartridge suitable for use in the said refrigerator.

Abstract: In accordance with the present invention, a casting system is provided which broadly comprises a core and a wax die spaced from said core, a refractory metal core having a first end seated within a slot in the core and a second end contacting the wax die for positioning the core relative to the wax die, and the refractory metal core having at least one of a mechanism for providing spring loading when closed in the wax die and a mechanism for mechanically locking the wax die to the core.

Abstract: An apparatus for shelling an investment casting pattern has a tank containing a coating material. There are means for holding the pattern immersed in the coating material. There may be means for vibrating the pattern during immersion of the pattern and a vacuum source coupled to the tank to withdraw air from at least one headspace of the tank.

Abstract: Pre-molding of wax or similar sacrificial material over one or more cores facilitates a subsequent molding over a core assembly. Individual cores or groups thereof may be pre-molded in a wax body. One or more such wax bodies may be assembled with other bodies and/or other cores to facilitate a main wax molding of such assembly.

Abstract: An at least two step heating process is used to strengthen the shell of an investment casting mold including a refractory metal core. The first stage may occur under otherwise oxidizing conditions at a low enough temperature to avoid substantial core oxidation. The second stage may occur under essentially non-oxidizing conditions at a higher temperature.

Abstract: An article has a characteristic thermal-mechanical stress principal direction. The article has a single crystal substrate having a lowest modulus direction within a target alignment with the principal direction.

Abstract: High performance single crystal investment cast components and methods of making same are described herein. Embodiments comprise systems for producing such components.

Abstract: A urology catheter is provided that includes an elongated body extending from a proximal end to a distal end. The body defines at least one lumen. A tip has a proximal end that is disposed in abutting relation with the distal end of the body such that the body is fixed with the tip. The tip defines a lateral opening that is defined by a wall including an external radius disposed in transition with an outer surface of the tip and an internal radius disposed in transition with an inner surface of the tip. The external radius has a non-perpendicular profile with the outer surface of the tip. An expandable member has a proximal portion disposed about the body and a distal portion disposed about the tip. A method of manufacturing the urology catheter is provided.

Abstract: A sacrificial core for forming an interior space of a part includes a ceramic core element and a first core element including a refractory metal element. The ceramic core element may be molded over the first core element or molded with assembly features permitting assembly with the first core element.

Abstract: An apparatus for shelling an investment casting pattern has a tank containing a coating material. There are means for holding the pattern immersed in the coating material. There may be means for vibrating the pattern during immersion of the pattern and a vacuum source coupled to the tank to withdraw air from at least one headspace of the tank.

Abstract: A method and apparatus are provided for detonation of a super-compressed insensitive energetic material by cylindrical implosion followed by an axial detonation to a detonation velocity several times that of TNT and a detonation pressure in excess of ten times that of TNT. The device provides a conical metal flyer shell within which is disposed a cylindrical anvil surrounded by explosive. The anvil retains an insensitive energetic material to be compressed and detonated. A first detonation of explosive by impact of the flyer shell generates a reverberating oblique shock wave system for sample compression. Axial detonation of the compressed sample through any length of a sample is achieved following the principal of matching the axial velocity and compression time of the oblique shock wave system to the detonation velocity and induction delay time of the compressed sample. The method and apparatus are also applicable to enhancing the effect of anti-armour and anti-hard-target munitions.

Abstract: In accordance with the present invention, a casting system is provided which broadly comprises a core and a wax die spaced from said core, a refractory metal core having a first end seated within a slot in the core and a second end contacting the wax die for positioning the core relative to the wax die, and the refractory metal core having at least one of a mechanism for providing spring loading when closed in the wax die and a mechanism for mechanically locking the wax die to the core.

Abstract: A method and apparatus are used to cast a number of elements such as turbine engine blades. The blades have an airfoil and a root for securing the blade to a disk. A number of mold sections each have internal surfaces for forming an associated at least one of the elements. The mold sections are assembled and molten alloy is introduced to the assembled mold sections.