Abstract: A device for centering a sensor assembly in a bore comprises a first support and a second support axially spaced apart along a central longitudinal axis of the device, one or both of the first and second supports configured to slide axially along the central longitudinal axis, and a plurality of arm assemblies, each arm assembly pivotally connected to the first and second supports by a respective pivot joint. One or both supports comprise an adjustment mechanism configured to set a maximum outer diameter of the device.

Abstract: Apparatus and methods are disclosed for a standalone and multi-game miniature golf structure. A sensor assembly located at an end of a putting surface of a putting structure includes a panel and a sensor. The panel is positioned adjacent to and below the end of the putting surface. The panel defines an upper surface along which a golf ball is to travel after dropping from the end of the putting surface. The upper surface includes a rear edge and a front edge. The sensor is positioned adjacent the panel to detect at which of a plurality of lateral positions the golf ball travels along the upper surface.

Abstract: A device for transporting a tool string down a bore comprises a body with a connection at one or both ends for in-line connection in a tool string, and a pair of wheels mounted to rotate relative to the body on a rotational axis perpendicular to a longitudinal axis. The device defines an outer form configured to orient the device in the bore during use so that a radial extremity of the wheels contacts a low side of a wall of the bore. The device further comprises an adjustment mechanism configured to provide for an angular orientation of the outer form of the device relative to an adjacent tool string section to be set, and a locking mechanism configured to lock the angular orientation relative to the adjacent tool string section so that the outer form of the device orients the device and adjacent tool string section in the bore.

Abstract: A method is described for the identification of individuals with a BMI of less than 25 who have a biochemical profile that corresponds to an overweight or obese phenotype. The method of highlighting this hidden obesity makes use of various biomarker combinations that can incorporate various analytes including leptin and complement C3.

Abstract: There is provided a gasket comprising a rigid core (2) defining an aperture (4). The core has a serrated profile (8) on at least one of its upper and lower outer surfaces and the core is divided into upper and lower parts (2a, 2b) each having a respective outer surface (6a, 6b) and also an inner surface (42, 44) opposite the outer surface. The gasket also includes an optional sealing facing (12, 14) on the at least one outer serrated profile surface, wherein an inner insulating layer (40) is located between the said upper and lower parts so that it is operable to substantially reduce electrical conduction between the said upper and lower parts. There is described a method of production of the gasket and use of the gasket.

Abstract: Haematuria is a considerable burden within primary and secondary care; too many haematuria patients are referred to secondary care for invasive and expensive investigations that could be managed in primary care. The current invention has identified biomarker combinations with utility for the diagnosis of bladder cancer in males. Using gender specific biomarker algorithms in combination with clinical risks that are associated with bladder cancer, would allow clinicians to better manage haematuria patients in primary care setting.

Abstract: There is provided a gasket (100) for sealing two mating surfaces, the gasket comprising: a rigid non-metal core (102) defining an aperture (104), the core comprising a first face (106) extending away from the aperture and a second face (122) opposite the first face; and at least one sealing layer (108); wherein the first face comprises: a substantially flat inner region (112) defining a plane; and a serrated region (110) comprising a plurality of serrations (118) that extend substantially perpendicular to the plane, wherein the substantially flat inner region is located between the aperture and the serrated region, wherein the serrations are recessed in the first face such that they do not cross the plane, wherein the at least one sealing layer overlays at least part of the serrated region of the first face.

Abstract: Single markers lack both sensitivity and specificity to stratify risk of PCa in patients who present with elevated tPSA and abnormal DRE. The novel combination of serum markers identified in this study could be employed to help triage patients into ‘low’ and ‘high’ risk categories, allowing general practitioners (GPs) to improve management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments.

Abstract: A device for centering a sensor assembly in a bore has three or more bow-spring assemblies spaced circumferentially apart around a longitudinal axis of the device and pivotally attached between first and second support members. Each bow-spring assembly comprises two or more bow-springs stacked together in a bow-spring stack, with each bow-spring in the bow-spring stack extending between first and second pivot members pivotally attached to the first and second support members.

Abstract: Apparatus and methods are disclosed for a standalone and multi-game miniature golf structure. A structure includes a digital display screen positioned to align vertically with a rear end of a putting surface and sensor(s) positioned below the digital display screen. The sensor(s) are configured to detect lateral positions at which balls cross the rear end. The structure includes processor(s), that for each shot of a plurality of miniature golf games, are configured to send command signals to the digital display screen to display putting target(s); identify, via the sensor(s), a lateral position at which a golf ball crosses the rear end of the putting surface; determine whether the lateral position of the golf ball aligns vertically with any of the putting target(s); and generate a score for the shot based on the lateral position of the golf ball relative to the putting target(s).

Abstract: A device for centering a sensor assembly in a bore comprises a plurality of arm assemblies connected first and second support members. Each arm assembly comprises a first arm pivotally connected to the first support member, a second arm pivotally connected to the second support member, and a third arm pivotally connected between the first and second arms. The third arm is pivotally connected to a third support member positioned axially between the first and second support members. The third arm extends across the longitudinal axis of the device so that in use each arm assembly contacts opposite sides of the bore to centralise the sensor assembly in the bore.

Abstract: A downhole tool for transmitting rotation to a casing string includes a tool body having a bore extending from a first end to a second end. The downhole tool also includes a cam positioned within the tool body, the cam being axially translatable along an axis of the bore. The downhole tool further includes a recess, formed in an outer diameter of the cam. The downhole tool includes a locking mechanism, positioned at least partially within the tool body. The locking mechanism includes a tool key. The locking mechanism also includes a biasing member, the biasing member driving the tool key toward the retracted position.

Abstract: A device for centering a sensor assembly in a bore comprises a plurality of arm assemblies spaced circumferentially apart around a central longitudinal axis of the device and connected between first and second support members. Each arm assembly comprises a first arm pivotally connected to the first support member by a first pivot joint having a first pivot axis, a second arm pivotally connected to the second support member by a second pivot joint having a second pivot axis, and the first and second arms pivotally connected together via a third pivot joint having a third pivot axis. The first pivot axis and the third pivot axis are located on a first side of a plane coincident with the central longitudinal axis of the device, and the second pivot axis is located on an opposite second side of the plane to achieve an improved mechanical advantage.

Abstract: A device for centering a sensor assembly in a bore comprises a first support and a second support axially spaced apart along a central longitudinal axis of the device, one or both of the first and second supports configured to slide axially along the central longitudinal axis, and a plurality of arm assemblies, each arm assembly pivotally connected to the first and second supports by a respective pivot joint. One or both supports comprise an adjustment mechanism configured to set a maximum outer diameter of the device.

Abstract: A device for transporting a tool string down a bore comprises a single unitary part mandrel comprising a connection at each end of the mandrel for in-line connection of the device in a tool string and a single unitary part annular body rotationally mounted to the mandrel to rotate relative to the mandrel about a longitudinal axis of the mandrel or tool string. A pair of wheels is rotationally mounted to the annular body to rotate relative to the mandrel on a rotational axis perpendicular to the longitudinal axis of the tool string. A collar is releasably coupled to the mandrel to allow for assembly of the annular body onto the mandrel from one end of the mandrel when the collar is disassembled from the mandrel and axially retain the annular body on the mandrel when the collar is assembled to the mandrel.

Abstract: A device for transporting a sensor assembly along a bore comprises an axle extending through a body of the device and mounted to rotate on a rotational axis perpendicular to a central longitudinal axis of the device. A wheel fixed to each end of the axle. The device has a conduit through the body for accommodating an electrical conductor to extend through the device from end-to-end. The conduit comprises a non-linear portion extending around the axle between the ends of the device.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: A sensor transportation apparatus to convey an elongate sensor assembly through a wellbore, the sensor transportation apparatus comprises a pair of axles and a pair of wheels corresponding with the pair of axles with each wheel mounted on a respective said axle to rotate about an axis of rotation perpendicular to a longitudinal axis of the elongate sensor assembly. A protection structure extends longitudinally around each wheel to prevent a side of the wheel from contacting a wall of the wellbore. Each wheel extends above and below the protection structure to contact a side of the wellbore.

Abstract: A centraliser comprises a mandrel, a first support member, a second support member, and a plurality of arm assemblies connected between the first and second support members. Each arm assembly comprises a first arm pivotally connected to the first support member at a first pivot axis and a second arm pivotally connected to the second support member at a second pivot axis, and the first and second arms pivotally connected together at a third pivot axis. The mandrel comprises a plurality of facets spaced apart around an outer surface of the mandrel to rotationally key the first and/or second support member to the mandrel, and each arm assembly is arranged so that the third pivot axis is located on a first side of a plane coincident with a central axis of the device and the first and second pivot axes are located on an opposite second side of the plane.

Abstract: The disclosure relates to a sensor transportation apparatus to convey an elongate sensor assembly through a wellbore. The sensor transportation apparatus comprises at least one engagement structure to connect the sensor transportation apparatus to the sensor assembly, and a pair of wheels arranged to rotate about an axis of rotation substantially perpendicular to a longitudinal axis of the sensor assembly when the transportation apparatus is connected to the sensor assembly, and an orientation structure comprising at least one orientation projection, in a transverse outline of the sensor transportation apparatus a said orientation projection extending between the pair of wheels so that the shortest distance between a centre of mass of the elongate sensor assembly and the wellbore wall is when the pair of wheels are in contact with the wellbore wall.