Abstract: are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

Abstract: The invention relates to methods and compositions for promoting bone growth, bone healing and/or bone formation. Disclosed herein are isolated truncated Wilms tumor on gene chromosome X (WTX) polypeptides and uses thereof. Also disclosed are methods of treating a bone related disease or condition in a subject by modulating the expression or activity of a (WTX) polypeptide in bone cells of the subject. The bone related disease or condition is any disease or condition including bone related trauma or injury due to any cause including surgery. The compositions and methods according to the invention are useful for enhancing and stimulating bone mineralization and for preferentially directing the differentiation of certain stem cells, thereby altering cell fate.

Abstract: A rack rail system engageable with a post of a rack. The rack rail system includes a rail assembly and a flange provided on at least an end of the rail assembly. The flange includes a pin insertable into an aperture of the post when the flange is adjacent to the post. The rack rail system further includes a clamp pivotably connected to the flange and movable from an open position and a closed position. The clamp receives both the post and the flange in the closed position.

Abstract: A structure and a method. The method includes: forming a dielectric layer on a substrate; forming electrically conductive first and second wires in the dielectric layer, top surfaces of the first and second wires coplanar with a top surface of the dielectric layer; and either (i) forming an electrically conductive third wire on the top surface of the dielectric layer, and over the top surfaces of the first and second wires, the third wire electrically contacting each of the first and second wires, the third wire not detectable by optical microscopy or (ii) forming an electrically conductive third wire between the top surface of the dielectric layer and the substrate, the third wire electrically contacting each of the first and second wires, the third wire not detectable by optical microscopy.

Abstract: One embodiment provides an air baffle assembly for controlling airflow through a cable opening in a rack. The rack is configured for removably supporting a plurality of modular electronic components. The cable opening on the rack receives a plurality of cables connected to the modular electronic components. The air baffle assembly includes a track secured to the rack adjacent to the cable opening and an air baffle movably supported on the track over the cable opening. The track includes a rail guideway. The air baffle includes at least a flexible first rail movably received by the first rail guideway. The first rail flares laterally along a range of engagement of the first rail with the first rail guideway, to bias the air baffle in one longitudinal direction.

Abstract: The immunoassay method and kit are provided for the detection and/or the determination of zolpidem. The disclosure provides novel antibodies, derived from a novel immunogen, that are highly sensitive and bind to zolpidem and its main urinary metabolite [3-(2-N,N-dimethylamino-2-oxoethyl)-6-methylimidazo[1,2-a]pyridin-2-yl]benzoic acid, enabling an extension of the detection window of zolpidem in individuals who have abused the drug, or have been victim of its side-effects or its criminal misuse.

Abstract: There is disclosed a skincare composition suitable for topical application to the skin. The composition comprises two or more active ingredients selected from the group consisting of a) dipalmitoyl hydroxyproline, salts and esters thereof; b) carnitine; and c) an extract of Haematococcus pluvialis. Compositions prepared in accordance with the invention are useful for improving the appearance of the skin.

Abstract: A rack for supporting electronic devices and modules with adjustable rails. The rack has a vertical wall with a set of holes at various elevations, each set of holes including at least a proximal hole evenly spaced apart from a distal hole. A longitudinally-extending rail has a set of clips for selectively securing the rail to the vertical wall, wherein the set of clips includes at least a proximal clip selectively receivable in the proximal hole at a selected elevation for supporting a proximal end of the rail and a distal clip selectively receivable in the distal hole at the selected elevation for supporting a distal end of the rail. The system may include a second rail for securing to an opposing vertical wall of the rack to form a shelf or bay for an electronic device. Each rail may be latched in place and can be selectively installed and removed without use of tools.

Abstract: A gasket for sealing two mating surfaces is described. The gasket has: a) an outer portion comprising a core interposed between sealing layers, the outer portion defining a first aperture, the core and/or the sealing layers defining an inner edge of the outer portion, the said inner edge immediately surrounding the first aperture; b) an inner portion comprising deformable material defining a second aperture therein, the inner portion having an inner edge defining the second aperture and an outer region designed to be secured to the outer portion so that the inner portion is held securely by the outer portion, the thickness of the inner portion being greater than the thickness of the outer portion so that in use the inner portion deforms to a greater extent than the outer portion. In some embodiments, the deformable inner portion includes a chemical treatment agent. The invention extends to methods of using the gaskets, uses for sealing corroded joints and methods of production of the gasket.

Abstract: An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of second reaction sites each comprising different known concentrations of an immobilized second analyte; (ii) removing any unbound first analyte; (iii) contacting the device with a second ligand that is detectably labelled and which has affinity for the first analyte, and a third ligand that is detectably labelled and which has affinity for the second analyte; (iv) removing any unbound second and third ligands; and (v) measuring the amount of second and third ligands, wherein measurement of the third ligand is used to establish a calibration curve, used to determine the amount of first analyte present in sample.

Abstract: An electronic device. The device including a module having opposite top surface and bottom surfaces; a first set of pads on the top surface of the module and a second set of pads on the bottom surface of the module substrate, wires within the module electrically connecting the first set of pads to the second set of pads; a set of solder interconnects in electrical and physical contact with a the second set of module pads; and a dielectric underfill layer formed on the bottom surface of the module, the underfill layer filling the space between lower regions of the solder interconnects of the set of solder interconnects, upper regions of the solder interconnects of the set of solder interconnects extending past a top surface of the underfill layer.

Abstract: An architecture and method is provided that facilitates serialization of a graph of objects into streams of data in an arbitrary format, and deserialization of the streams of data back into the graph of objects. The architecture provides a number of services associated with the basic functionality of serialization and deserialization. The services can be employed to implement transparent remoting, copy items to a clipboard and save data to a file. The present invention provides facilities which support the plugging in of a new serialization encoding by separating the encoding from the reading and reinstantiation of the graph of objects which the encoding describes. Objects in a graph of objects are serialized and deserialized based on a selected rule set for that object. A rule set can be provided by a class author within a class or within a third party file referred to as a surrogate.

Abstract: A method of monitoring the properties of a biological or chemical sample. The method includes carrying out a plurality of different tests on the sample to generate corresponding test data; optionally carrying out a preliminary processing of the test data to generate partially processed data; storing the test data and/or partially processed data; causing a processing system to analyze a user-defined selection of the test data or partially processed data to generate result data relating to one or more properties of the sample; and subsequent to the previous step, receiving a second user defined selection of the test data or partially processed data, different from the first selection, and causing the processing system to analyze the second user-defined selection of the test data or partially processed data to generate second result data relating to one or more properties of the sample different from the properties corresponding to the first user-defined selection.

Abstract: A rack rail system engageable with a post of a rack. The rack rail system includes a rail assembly and a flange provided on at least an end of the rail assembly. The flange includes a pin insertable into an aperture of the post when the flange is adjacent to the post. The rack rail system further includes a clamp pivotably connected to the flange and movable from an open position and a closed position. The clamp receives both the post and the flange in the closed position.

Abstract: A composition for the prevention or inhibition of free radical-induced effect on the skin and/or hair comprises at least three antioxidant agents selected from the group consisting of ginkgo extract, emblica extract, dimethylmethoxy chromanol, pine bark extract, and rosemary extract.

Abstract: An apparatus for the applying of refractory material in 360 degrees while the apparatus is raised or lowered vertically or inserted and retracted horizontally can apply a layer of material continuously on the interior surface of a hot vessel. Wet mixed refractory material is supplied to an applicator and pressurized air is supplied to the applicator so as to rotate a spinner head on the applicator. The apparatus includes a shroud around the housing of the applicator which conveys the pressurized air around the housing to cool the housing below the temperature of the vessel. Also described is a method of applying refractory material by a spinner head on the applicator in the form of a spray to hot metallurgical vessels such as the snorkel tubes of vacuum degassers and ladles.

Abstract: A rack rail system engageable with a post of a rack. The rack rail system includes a rail assembly and a flange provided on at least an end of the rail assembly. The flange includes a pin insertable into an aperture of the post when the flange is adjacent to the post. The rack rail system further includes a clamp pivotably connected to the flange and movable from an open position and a closed position. The clamp receives both the post and the flange in the closed position.