Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.

Abstract: Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.

Abstract: A method of monitoring an operating parameter of an apparatus. The method comprises taking a measurement of the operating parameter of the apparatus on multiple occasions. The mean and standard deviation of a set of threshold determining values is then determined, the threshold determining values each being dependent on at least one of the operating parameter measurements. Thereafter an event threshold, dependent on the mean and standard deviation of the set of threshold determining values is determined. The operating condition value is monitored, where the operating condition value at any given time is dependent on at least one of the operating parameter measurements. Finally an event signal is generated if the operating condition value is in a regime beyond the event threshold.

Abstract: The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6, R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as wel

Abstract: A method is for communicating by tracking time varying channels in a multiple access packet based communication network. Each packet includes a preamble portion including a data symbol, and a data portion including data symbols. The method may include initializing a channel estimate reference from an initial channel estimate based upon the data symbol in a preamble portion of a received packet, and updating the channel estimate reference based upon a channel estimate of a current data symbol and a previously received data symbol from the data symbols in a data portion of the received packet. The method may also include repeating the updating upon receipt of a subsequent data symbol from the data symbols in the data portion of the received packet.

Abstract: Disclosed are substituted quinolines of formula 1 wherein R1 and R2 are defined herein, the processing of making and using the same.

Abstract: The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.

Abstract: A method of determining an overlay error. Measuring an overlay target having process-induced asymmetry. Constructing a model of the target. Modifying the model, e.g., by moving one of the structures to compensate for the asymmetry. Calculating an asymmetry-induced overlay error using the modified model. Determining an overlay error in a production target by subtracting the asymmetry-induced overlay error from a measured overlay error. In one example, the model is modified by varying asymmetry p(n?), p(n?) and the calculating an asymmetry-induced overlay error is repeated for a plurality of scatterometer measurement recipes and the step of determining an overlay error in a production target uses the calculated asymmetry-induced overlay errors to select an optimum scatterometer measurement recipe used to measure the production target.

Abstract: An apparatus for the applying of refractory material in 360 degrees while the apparatus is raised or lowered vertically or inserted and retracted horizontally can apply a layer of material continuously on the interior surface of a hot vessel. Wet mixed refractory material is supplied to an applicator and pressurized air is supplied to the applicator so as to rotate a spinner head on the applicator. The apparatus includes a shroud around the housing of the applicator which conveys the pressurized air around the housing to cool the housing below the temperature of the vessel. Also described is a method of applying refractory material by a spinner head on the applicator in the form of a spray to hot metallurgical vessels such as the snorkel tubes of vacuum degassers and ladles.

Abstract: The invention relates to novel immunogens, antibodies, methods and kits for use in immunoassays to detect and quantify zaleplon, metabolites of zaleplon and indiplon. These are the first described immunoassays for these compounds and have greater sensitivity than alternative analytical techniques.

Abstract: Methods of treating, preventing and ameliorating bacteria! infections with 1,2-benzisothiazolinone and isoindolinone derivatives are disclosed. Pharmaceutical compositions containing 1,2-benzisothiazolinone and isoindolinone derivatives are useful for treating bacteria! infections caused by drug resistant strains of bacteria, including but not limited to methicillin and vancomycin bacterial organisms.

Abstract: A wind turbine drivetrain is disclosed. The wind turbine drivetrain includes a planetary gearbox. The planetary gearbox includes a carrier rotatably driven at a first input rotational speed, and a planet gear rotatably mounted to the carrier. The planetary gearbox further includes a sun gear rotatably coupled to the planet gear, and a ring gear rotatably coupled to the planet gear. One of the carrier, the sun gear, or the ring gear is selectively rotatably driven at a second input rotational speed. The wind turbine drivetrain further includes an output gear rotatably driven by the planetary gearbox at an output rotational speed, and a motor selectively operable to rotatably drive the one of the carrier, the sun gear, or the ring gear.

Abstract: Devices and methods for preparing a transcatheter heart valve system. The device includes a housing, sealing apparatuses and a port. The housing forms a chamber sized to receive a prosthetic valve and a portion of a delivery device. During use, the prosthesis is seated in the chamber, and the sealing apparatuses operated to seal the chamber about the delivery device. Air bubbles in a liquid delivered through the delivery device and to the chamber are removed from the system via the port, thereby flushing the system. Further, the device is manipulated to permit loading of the prosthesis into the delivery device in an air bubble-free environment.

Abstract: A wind turbine drivetrain is disclosed. The wind turbine drivetrain includes a planetary gearbox. The planetary gearbox includes a carrier rotatably driven at a first input rotational speed, and a planet gear rotatably mounted to the carrier. The planetary gearbox further includes a sun gear rotatably coupled to the planet gear, and a ring gear rotatably coupled to the planet gear. One of the carrier, the sun gear, or the ring gear is selectively rotatably driven at a second input rotational speed. The wind turbine drivetrain further includes an output gear rotatably driven by the planetary gearbox at an output rotational speed, and a motor selectively operable to rotatably drive the one of the carrier, the sun gear, or the ring gear.

Abstract: An entertainment device comprises a display generator arranged to generate for display a representation of an on-line virtual environment comprising one or more avatars corresponding to users of one or more remote entertainment devices each interacting with that online virtual environment, a network communicator operable to receive data representative of the actions of other users within the on-line virtual environment and to receive content sourced from one or more users of the one or more remote entertainment devices interacting with that online virtual environment, an input device operable by the user to instigate a reporting event and a content identifier operable to generate information indicative of content sourced from one or more users of the one or more remote entertainment devices and that was available to the entertainment device when the reporting event was instigated, and in which the network communicator is operable to transmit a report to a remote device comprising said generated information.

Abstract: The invention relates to new substituted pyridinyl-pyrimidines of formula 1 wherein ring A is a five-membered saturated or unsaturated carbocyclic ring which optionally comprises one, two or three heteroatoms each independently from each other selected from the group N, S and O, wherein R1, R2, R4, R3, R5 and R6 are defined as in claim 1 and wherein ring A is further optionally substituted by one or two further substituents and the pharmaceutically acceptable salts, diastereomers, enantiomers, racemates, hydrates and solvates of the aforementioned compounds.

Abstract: Methods and systems for seamlessly integrating an end-to-end acquisition process using a flexible data structure are disclosed. A flexible data structure consistent with these methods and systems may connect the buyer's requirement to the vendor's proposed solution, facilitating a requirement-by-requirement evaluation process allowing buyers to evaluate content as well as price of a proposal. Embodiments of the present invention standardize the format of proposals, allowing buyers to more easily compare vendors' proposals side-by-side. Still other embodiments of the present invention produce an error checking report to further aid vendors in improving proposals and buyers in evaluating proposals.

Abstract: Compounds of general formula (I): wherein R1, R2, R3, R4, R5, R6, X and Y are as defined herein are inhibitors of Bcl-2 and are useful for treating diseases characterized by abnormal cell growth and/or dysregulated apoptosis.

Abstract: Distal tips for use with delivery catheters are disclosed that are configured to maintain complete engagement between the distal tip and a distal opening of a sheath component of the delivery catheter so as to prevent separation therebetween and/or to prevent fish-mouthing of a distal leading edge of the sheath component during in vivo use. Distal tips so configured realize one or more of the objectives of safer tracking of the delivery catheter through the vasculature, safe crossing of the delivery catheter through structural components of the vasculature and heart, such as through native valves, and safe removal of the delivery catheter post deployment.

Abstract: An elastic percutaneous elastic introducer sheath is disclosed which can locally expand and reduce to accommodate a transcatheter medical device. The elastic introducer sheath includes a non-circumferentially continuous wire structure, a liner, and a jacket.